This program requests 5 predoctoral and 1 postdoctoral positions for training in immune system development and regulation (ISDR). The program has expanded to 28 trainers with expertise in the development and regulation of immune system, which are a subset of the Immunology Graduate Group (IGG) faculty at the University of Pennsylvania. The IGG at Penn is a discipline-based graduate training program and, as the first in the country to offer a degree in Immunology, has a >30-year record of outstanding training. The academic elements of the IGG curriculum form the core experiences for trainees in the proposed ISDR program, and reflect a proven mixture of coursework, laboratory rotations, research presentations, and thesis research. These are enriched by a large array of additional activities that foster scientific exchange and discussion, including ongoing activities such as our annual retreat and weekly immunology colloquium, as well as an agreement that affords training experiences with distinguished adjunct faculty on the NIH Bethesda campus. The assembled trainers for this grant have extensive and highly productive training records in the area of immune system development and regulation, as well as substantial research support to assure quality and continuity of the training experience. The breadth and strength of the assembled training faculty affords a diverse array of potential trainee mentors. The Immunology Predoctoral program has over 100 applicants annually, which are a subset of over 1,000 applicants to biomedical graduate studies at the University of Pennsylvania School of Medicine. The Immunology program recruits between 8 to 12 PhD and 2 to 5 MD-PhD trainees per year, yielding a student body of ~60 students. This program focuses specifically on students/faculty whose research is directed towards understanding the development and regulation of the immune system and immune responses. In this regard, the ISDR fosters research and research training that bear directly on control and manipulation of the immune system in health and disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI055428-10
Application #
8296482
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
2003-06-01
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2014-07-31
Support Year
10
Fiscal Year
2012
Total Cost
$234,125
Indirect Cost
$12,603
Name
University of Pennsylvania
Department
Pathology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Naradikian, Martin S; Myles, Arpita; Beiting, Daniel P et al. (2016) Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells. J Immunol 197:1023-8
Kotzin, Jonathan J; Spencer, Sean P; McCright, Sam J et al. (2016) The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Nature 537:239-243
Freund, Jacquelyn; May, Rebecca M; Yang, Enjun et al. (2016) Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells. PLoS Biol 14:e1002526
Naradikian, Martin S; Hao, Yi; Cancro, Michael P (2016) Age-associated B cells: key mediators of both protective and autoreactive humoral responses. Immunol Rev 269:118-29
DeMicco, Amy; Naradikian, Martin S; Sindhava, Vishal J et al. (2015) B Cell-Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell-Dependent Immune Response In Vivo. J Immunol 195:3449-62
Nündel, Kerstin; Green, Nathaniel M; Shaffer, Arthur L et al. (2015) Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses. J Immunol 194:2504-12
Naradikian, Martin S; Perate, Alison R; Cancro, Michael P (2015) BAFF receptors and ligands create independent homeostatic niches for B cell subsets. Curr Opin Immunol 34:126-9
Goenka, Radhika; Scholz, Jean L; Naradikian, Martin S et al. (2014) Memory B cells form in aged mice despite impaired affinity maturation and germinal center kinetics. Exp Gerontol 54:109-15
Oropallo, Michael A; Goenka, Radhika; Cancro, Michael P (2014) Spinal cord injury impacts B cell production, homeostasis, and activation. Semin Immunol 26:421-7
Goenka, Radhika; Scholz, Jean L; Sindhava, Vishal J et al. (2014) New roles for the BLyS/BAFF family in antigen-experienced B cell niches. Cytokine Growth Factor Rev 25:107-13

Showing the most recent 10 out of 56 publications