This program requests 4 predoctoral positions for training in immune system development and regulation (ISDR). The program includes 26 trainers with expertise in the development and regulation of the immune system, who are a subset of the Immunology Graduate Group (IGG) at the University of Pennsylvania. This discipline-based training program has a >35-year record of outstanding training. The academic elements of the IGG curriculum form the core experiences for trainees in the ISDR program, and reflect a proven yet evolving mixture of coursework, laboratory rotations, research presentations, and thesis research. These are enriched by a large array of additional activities that foster scientific exchange and discussion, including ongoing activities such as our annual 2.5-day retreat, weekly colloquium, and weekly work-in-progress series, as well as an agreement that affords training with adjunct faculty on the NIH Bethesda campus. The assembled trainers for this grant have highly productive training records in the area of immune system development and regulation, as well as over $75M in annual research support to assure quality and continuity of the training experience. The breadth and strength of the assembled training faculty affords a diverse array of potential trainee mentors. The program has over 100 applicants annually, which are a subset of over 1,000 applicants to biomedical graduate studies at the University of Pennsylvania. The IGG program recruits between 8 to 12 PhD and 2 to 5 MD-PhD trainees per year, yielding a student body of ~60 students, and the ISDR supports a subset of the upper 15% of these. The ISDR focuses specifically on students/faculty whose research is directed towards understanding the development and regulation of the immune system and immune responses. In this regard, the ISDR fosters research training that bears directly on control and manipulation of the immune system in health and disease.
Lymphocytes are cells of the immune system that govern responses to pathogens and vaccines, and whose failed regulation can lead to inflammatory and autoimmune diseases. This program will prepare outstanding scientists to study lymphocyte development and regulation. This will ultimately foster advances in vaccine development and organ transplantation, as well as therapies for autoimmune disease and cancer.
|Naradikian, Martin S; Myles, Arpita; Beiting, Daniel P et al. (2016) Cutting Edge: IL-4, IL-21, and IFN-Î³ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells. J Immunol 197:1023-8|
|Kotzin, Jonathan J; Spencer, Sean P; McCright, Sam J et al. (2016) The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Nature 537:239-243|
|Freund, Jacquelyn; May, Rebecca M; Yang, Enjun et al. (2016) Activating Receptor Signals Drive Receptor Diversity in Developing Natural Killer Cells. PLoS Biol 14:e1002526|
|Naradikian, Martin S; Hao, Yi; Cancro, Michael P (2016) Age-associated B cells: key mediators of both protective and autoreactive humoral responses. Immunol Rev 269:118-29|
|DeMicco, Amy; Naradikian, Martin S; Sindhava, Vishal J et al. (2015) B Cell-Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell-Dependent Immune Response In Vivo. J Immunol 195:3449-62|
|NÃ¼ndel, Kerstin; Green, Nathaniel M; Shaffer, Arthur L et al. (2015) Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses. J Immunol 194:2504-12|
|Naradikian, Martin S; Perate, Alison R; Cancro, Michael P (2015) BAFF receptors and ligands create independent homeostatic niches for B cell subsets. Curr Opin Immunol 34:126-9|
|Goenka, Radhika; Scholz, Jean L; Naradikian, Martin S et al. (2014) Memory B cells form in aged mice despite impaired affinity maturation and germinal center kinetics. Exp Gerontol 54:109-15|
|Oropallo, Michael A; Goenka, Radhika; Cancro, Michael P (2014) Spinal cord injury impacts B cell production, homeostasis, and activation. Semin Immunol 26:421-7|
|Goenka, Radhika; Scholz, Jean L; Sindhava, Vishal J et al. (2014) New roles for the BLyS/BAFF family in antigen-experienced B cell niches. Cytokine Growth Factor Rev 25:107-13|
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