The Biodefense Research Training Program is in its 5th year. Predoctoral trainees enter the Program at the start of the 2nd graduate year, after completion of research rotations &qualifying exam. Postdoctoral fellows enter the Program after selecting a Program mentor's lab. Admission is competitive, with 16% and 3% of qualified 2nd year predoc and postdoc applicants accepted in 2006. Research encompasses the immunology, cell biology, pharmacology and microbiology of Category A-C agents of bioterrorism. The training of predoctoral students, M.D., and Ph.D. postdoctoral fellows is enriched by special activities of the Program, including a monthly breakfast research-in-progress meeting solely for the trainees chaired by the Program Director, two graduate courses in Biodefense, an expanded 2 semester course in molecular mechanisms of microbial pathogenesis and virology, an MPH degree program, Career Day, journal club, and coordination of training with the Middle Atlantic Center of Excellence for Biodefense. The Program Director is William Petri, M.D., Ph.D. who conducts Biodefense research on amoebiasis, and is Chief of the Infectious Diseases Division. An Executive Committee provides Program oversight and trainee selection. Six departments contribute a total of 18 faculty members (1 DVM, 5 MD and 16 PhD). All labs are within a 5 minute walk, and all faculty members collaborate, with 80% co-authoring papers. 100% of the preceptors are extramurally supported by the NIH through at least 2008, at an average of $900,000 in annual direct costs/faculty (a 90% increase since 2001). The average Preceptor has trained >10 pre- and/or postdoctoral students, but select """"""""up and coming"""""""" junior faculty with less extensive training records are also included with more experienced faculty provided as co- mentors. Funds are requested to train 4 predoctoral fellows and 2 postdoctoral fellows (an increase in 1 predoctoral position). Progress includes predoctoral trainee GRE scores of 660V/690Q and GPA of 3.5, 100% of trainees in Biodefense labs, and 94% retention of trainees in the Program. 67% (12/18) of the mentors have trained at least one trainee. 17% of trainees are underrepresented minorities. Women comprise 61% of trainees and 33% of faculty. 6 trainees have graduated, with an average of 3 papers published or submitted, with 83% active in research (5/6 - the 6th is currently a stay-at-home mother). Evaluations of the Program include an annual faculty retreat and a trainee questionnaire.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI055432-08
Application #
7822838
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Peters, Kent
Project Start
2003-08-01
Project End
2013-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
8
Fiscal Year
2010
Total Cost
$242,494
Indirect Cost
Name
University of Virginia
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Gilmartin, Allissia A; Ralston, Katherine S; Petri Jr, William A (2017) Inhibition of Amebic Lysosomal Acidification Blocks Amebic Trogocytosis and Cell Killing. MBio 8:
Margulieux, Katie R; Liebov, Benjamin K; Tirumala, Venkata S K K S et al. (2017) Bacillus anthracis Peptidoglycan Integrity Is Disrupted by the Chemokine CXCL10 through the FtsE/X Complex. Front Microbiol 8:740
Mathers, Amy J; Stoesser, Nicole; Chai, Weidong et al. (2017) Chromosomal Integration of the Klebsiella pneumoniae Carbapenemase Gene, blaKPC, in Klebsiella Species Is Elusive but Not Rare. Antimicrob Agents Chemother 61:
Owings, Joshua P; Kuiper, Emily G; Prezioso, Samantha M et al. (2016) Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase. J Biol Chem 291:3280-90
Korpe, Poonum S; Haque, Rashidul; Gilchrist, Carol et al. (2016) Natural History of Cryptosporidiosis in a Longitudinal Study of Slum-Dwelling Bangladeshi Children: Association with Severe Malnutrition. PLoS Negl Trop Dis 10:e0004564
PĂ©rez, Natalie; Johnson, Richard; Sen, Bhaswati et al. (2016) Two parallel pathways for ferric and ferrous iron acquisition support growth and virulence of the intracellular pathogen Francisella tularensis Schu S4. Microbiologyopen 5:453-68
Qin, Aiping; Zhang, Yan; Clark, Melinda E et al. (2016) Components of the type six secretion system are substrates of Francisella tularensis Schu S4 DsbA-like FipB protein. Virulence 7:882-894
Luzader, Deborah H; Kendall, Melissa M (2016) Commensal 'trail of bread crumbs' provide pathogens with a map to the intestinal landscape. Curr Opin Microbiol 29:68-73
Burgess, Stacey L; Lu, Miao; Ma, Jennie Z et al. (2016) Inflammatory markers predict episodes of wheezing during the first year of life in Bangladesh. Respir Med 110:53-7
Naylor, Caitlin; Petri Jr, William A (2016) Leptin Regulation of Immune Responses. Trends Mol Med 22:88-98

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