This is the revised competing continuation application for the Biodefense Training Program at the University of Virginia. The Program received an Impact/Priority Score of 20 at the 2011 meeting of the MID study section. Principal strengths noted in the critique included the exceptionally well-funded trainers, the value added to trainees through meetings, symposia, and access to resources of the Middle Atlantic Regional Center for Excellence for Biodefense, the exceptional institutional support, and the thorough training plan. Weaknesses were considered negligible. The Program objective is to provide a rich interdisciplinary experience in Biodefense Category A-C Agent research, with the goal to prepare trainees for careers in independent investigation. The cornerstone is side- by-side education of predoctoral, Ph.D. and M.D. postdoctoral fellows. The Program combines the expertise of 16 Mentors from seven different departments, all within a five minute walking distance. All but one (a new recruit on start-up) of the Mentors are extramurally supported by the NIH through at least 2013, with $21.9 million total annual direct costs (29% increase since 2008). The average Mentor has trained >ten pre- and/or postdoctoral students, but select Junior Mentors are included but required to have a senior Program faculty as co-mentor. Training is enriched by state-of-the art BSL-3 and BSL-2 laboratory space constructed by the University for the Program, a twice-monthly "Research in Biodefense and Infectious Diseases" meeting that pairs a predoctoral and postdoctoral fellow to discuss research-in-progress, a graduate course focused on Biodefense, a new graduate course schedule that promotes focused time in research, an Annual Research Day, Career Development Forums, an innovative basic-clinical Journal Club, and coordination of training with the Middle Atlantic Regional Center of Excellence for Biodefense. Evaluations of the Program include an annual faculty retreat, external advisory committee and annual trainee questionnaire. Funds are requested to train three predoctoral fellows and two postdoctoral fellows (a decrease in one postdoctoral position based on the recommendation of the MID study section). Category A Agents are a focus with approximately half of the trainees studying Ebola, anthrax or tularemia. First authored peer-reviewed original research publications at graduation average two for predocs and 1.4 for postdocs, with high impact papers in Nature, Science, Cell, and PNAS. 84% of predocs and 92% of postdocs that have graduated from the Program remain active in research, most in biodefense. 29% of trainees supported in the last funding period are underrepresented minorities, and there have been 79% and 100% graduation rates respectively for pre- and postdoctoral trainees.

Public Health Relevance

Category A through C Agents of Biodefense remain significant threats to health. The Biodefense Training Program prepares predoctoral and postdoctoral trainees for research in biodefense, providing a rich interdisciplinary environment that promotes innovative science.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Microbiology and Infectious Diseases B Subcommittee (MID)
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Robbins, Christiane M
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University of Virginia
Internal Medicine/Medicine
Schools of Medicine
United States
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PĂ©rez, Natalie Marie; Ramakrishnan, Girija (2014) The reduced genome of the Francisella tularensis live vaccine strain (LVS) encodes two iron acquisition systems essential for optimal growth and virulence. PLoS One 9:e93558
Operario, Darwin J; Moonah, Shannon; Houpt, Eric (2014) Hemolytic uremic syndrome following infection with O111 Shiga toxin-producing Escherichia coli revealed through molecular diagnostics. J Clin Microbiol 52:1003-5
Moonah, Shannon N; Abhyankar, Mayuresh M; Haque, Rashidul et al. (2014) The macrophage migration inhibitory factor homolog of Entamoeba histolytica binds to and immunomodulates host macrophages. Infect Immun 82:3523-30
Jiang, Nona M; Tofail, Fahmida; Moonah, Shannon N et al. (2014) Febrile illness and pro-inflammatory cytokines are associated with lower neurodevelopmental scores in Bangladeshi infants living in poverty. BMC Pediatr 14:50
Moonah, Shannon N; Jiang, Nona M; Petri Jr, William A (2013) Host immune response to intestinal amebiasis. PLoS Pathog 9:e1003489
Damron, F Heath; Owings, Joshua P; Okkotsu, Yuta et al. (2012) Analysis of the Pseudomonas aeruginosa regulon controlled by the sensor kinase KinB and sigma factor RpoN. J Bacteriol 194:1317-30
Brecher, Matthew; Schornberg, Kathryn L; Delos, Sue E et al. (2012) Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change. J Virol 86:364-72
Mathers, Amy J; Cox, Heather L; Kitchel, Brandon et al. (2011) Molecular dissection of an outbreak of carbapenem-resistant enterobacteriaceae reveals Intergenus KPC carbapenemase transmission through a promiscuous plasmid. MBio 2:e00204-11
Hargadon, Kristian M; Zhou, Haixia; Albrecht, Randy A et al. (2011) Major histocompatibility complex class II expression and hemagglutinin subtype influence the infectivity of type A influenza virus for respiratory dendritic cells. J Virol 85:11955-63
Crawford, Matthew A; Lowe, David E; Fisher, Debra J et al. (2011) Identification of the bacterial protein FtsX as a unique target of chemokine-mediated antimicrobial activity against Bacillus anthracis. Proc Natl Acad Sci U S A 108:17159-64

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