This application is for a new training grant in Microbial Pathogenesis at the University of Utah. Microbial Pathogenesis is receiving strong institutional attention and support at many levels on campus. The success of the Microbial Pathogenesis Seminar Series in bringing together basic scientists and clinicians on a regular basis to hear outstanding scientific presentations has led to other new initiatives including recruitment of new faculty in Microbial Pathogenesis and inclusion of Microbiology/Immunology as one of highlighted interested groups of the interdepartmental Graduate Program in Molecular Biology. Microbial Pathogenesis has been highlighted as one of the University's high priorities for development, and the commitment to a new building to house many of the faculty in Microbial Pathogenesis together is part of this plan. Currently, there are 38 faculty members participating in training graduate students and research fellows in Microbial Pathogenesis, representing both basic scientists and physician scientists. Diverse areas of Microbial Pathogenesis are represented including: Structure, Assembly, and Pathogenesis of HIV; Viral Pathogenesis; Bacterial Pathogenesis; Microbial Genomes and Gene Expression in Microbes; Host Defense and Immune Responses; and Genetics of Susceptibility to Microbial Infections. Students and post-doctoral trainees will work with mentors studying Microbial Pathogenesis and receive instruction in Microbial Pathogenesis including course work and departmental training activities, and participation in the Microbial Pathogenesis Seminar Series, Training Grant Sponsored Journal Club and Annual Retreat. This application requests funds for 5 pre-doctoral and 3 post-doctoral trainees annually.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI055434-03
Application #
7070084
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
2004-09-01
Project End
2009-05-31
Budget Start
2006-06-01
Budget End
2007-05-31
Support Year
3
Fiscal Year
2006
Total Cost
$246,030
Indirect Cost
Name
University of Utah
Department
Pathology
Type
Schools of Medicine
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Whiteside, Sarah K; Snook, Jeremy P; Ma, Ying et al. (2018) IL-10 Deficiency Reveals a Role for TLR2-Dependent Bystander Activation of T Cells in Lyme Arthritis. J Immunol 200:1457-1470
Libbey, J E; Sanchez, J M; Doty, D J et al. (2018) Variations in diet cause alterations in microbiota and metabolites that follow changes in disease severity in a multiple sclerosis model. Benef Microbes 9:495-513
Whiteside, Sarah K; Snook, Jeremy P; Williams, Matthew A et al. (2018) Bystander T Cells: A Balancing Act of Friends and Foes. Trends Immunol 39:1021-1035
Redman, Joseph S; Francis, J Nicholas; Marquardt, Robert et al. (2018) Pharmacokinetic and Chemical Synthesis Optimization of a Potent d-Peptide HIV Entry Inhibitor Suitable for Extended-Release Delivery. Mol Pharm 15:1169-1179
DePaula-Silva, Ana Beatriz; Sonderegger, F Lynn; Libbey, Jane E et al. (2018) The immune response to picornavirus infection and the effect of immune manipulation on acute seizures. J Neurovirol 24:464-477
Han, Han; Monroe, Nicole; Sundquist, Wesley I et al. (2017) The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets. Elife 6:
DePaula-Silva, Ana Beatriz; Hanak, Tyler J; Libbey, Jane E et al. (2017) Theiler's murine encephalomyelitis virus infection of SJL/J and C57BL/6J mice: Models for multiple sclerosis and epilepsy. J Neuroimmunol 308:30-42
Cone, Kelsey R; Kronenberg, Zev N; Yandell, Mark et al. (2017) Emergence of a Viral RNA Polymerase Variant during Gene Copy Number Amplification Promotes Rapid Evolution of Vaccinia Virus. J Virol 91:
Monroe, Nicole; Han, Han; Shen, Peter S et al. (2017) Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase. Elife 6:
Chiaro, Tyson R; Soto, Ray; Zac Stephens, W et al. (2017) A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice. Sci Transl Med 9:

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