The goal of the Immunology and Infectious Disease Training Program at Indiana University School of Medicine is to develop diverse, multi-faceted scientists capable of responding to the nation's health and educational needs in the areas of host immunity and infection. Advanced knowledge of the immune system and infectious agents is essential given their impact on an increasing number of issues in human health including metabolic, vascular and cardiac diseases, aging, neural disorders, and cancer. This renewal application seeks continued support for years 11-15 to train pre- and postdoctoral fellows as well as short-term students in immunology and infectious diseases research. Institutional commitment to this training program is strong and includes financial support for trainee education and program direction, as well as state of the art facilities for basic and translational investigations. The program offers students and fellows formal and applied training within an interactive, multi-disciplinary medical center environment. The Immunology and Infectious Diseases Training Program unites twenty-three faculty with more than 80 current trainees from basic and clinical departments for integrated and innovative research and educational opportunities. Strengths of the program include the highly collaborative research of the faculty, an established program for mentoring at all levels, an extensive track record of relevant, quality publications from mentors and trainees, program mentors' sustained acquisition of extramural research funding, and successful placement of trainees in relevant careers including academics, medicine, government, and industry. Trainees benefit from the active research environment within the program including research centers, core facilities, and opportunities for teaching, co-mentoring, and career development. Comprehensive training is offered through didactic courses including bioethics, research seminars and conferences, program-specific journal clubs and meetings, grant and career workshops, and hands-on faculty mentoring. Program fellowship support is offered to trainees for two-three years with required annual reviews to ensure success. Fellowships are offered to pre-doctoral students in their 2nd year and beyond, while both junior and senior postdoctoral fellows are eligible for program support. Short-term trainees are part of an innovative initiative to encourage students from under-represented groups to consider careers in translational research related to immunology and infectious diseases. Altogether, this active and successful training program remains poised to prepare trainees for central roles in health and education-related professions.

Public Health Relevance

Discoveries related to immunology and infectious diseases remain critical to disease treatment and prevention. The development of a diverse and resilient workforce knowledgeable in these areas is critical, and is the key goal for this training program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI060519-12
Application #
8891349
Study Section
Allergy, Immunology, and Transplantation Research Committee (AITC)
Program Officer
Robbins, Christiane M
Project Start
2004-09-01
Project End
2019-07-31
Budget Start
2015-08-01
Budget End
2016-07-31
Support Year
12
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
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Brandt, Stephanie L; Putnam, Nicole E; Cassat, James E et al. (2018) Innate Immunity to Staphylococcus aureus: Evolving Paradigms in Soft Tissue and Invasive Infections. J Immunol 200:3871-3880
Kono, Tatsuyoshi; Tong, Xin; Taleb, Solaema et al. (2018) Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic ?-Cell. Diabetes 67:2293-2304
Brandt, Stephanie L; Wang, Sue; Dejani, Naiara N et al. (2018) Excessive localized leukotriene B4 levels dictate poor skin host defense in diabetic mice. JCI Insight 3:
Bagaitkar, Juhi; Huang, Jing; Zeng, Melody Yue et al. (2018) NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages. Blood 131:2367-2378
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Brandt, Stephanie L; Serezani, C Henrique (2017) Too much of a good thing: How modulating LTB4 actions restore host defense in homeostasis or disease. Semin Immunol 33:37-43
Ulrich, Benjamin J; Verdan, Felipe Fortino; McKenzie, Andrew N J et al. (2017) STAT3 Activation Impairs the Stability of Th9 Cells. J Immunol 198:2302-2309
Justis, Anna V; Hansen, Bryan; Beare, Paul A et al. (2017) Interactions between the Coxiella burnetii parasitophorous vacuole and the endoplasmic reticulum involve the host protein ORP1L. Cell Microbiol 19:
Culleton, Sara P; Kanginakudru, Sriramana; DeSmet, Marsha et al. (2017) Phosphorylation of the Bovine Papillomavirus E2 Protein on Tyrosine Regulates Its Transcription and Replication Functions. J Virol 91:

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