This is a request for new funding to support a comprehensive pre- and postdoctoral NRSA Training Program in Viral Replication at Northwestern University. The goal of this program is to train highly motivated students and postdoctoral fellows to be independent investigators in the areas of Viral Replication. Diseases caused by viral infection remain major health problems and new emerging viruses such as SARS, West Nile, monkeypox and Ebola have created significant concerns in the health community worldwide. In addition, the threat of using viral agents for bioterrorism has recently become a reality. Given the significance of these health issues and the potential threat of bioterrorism, virology continues to be an important area for study and the training of young scientists in the field of virology is of high priority. Northwestern has major research and training strengths in the areas of virology and this proposal seeks to expand the training program for pre and postdoctoral students by funding from the NIAD for a Viral Replication Training Grant (VRTG). All VRTG students will receive formal coursework and training in fundamental aspects of virology, as well as exposure to the vast body of research on cell and molecular biology. Most students will also receive formal training in allied fields including genetics, developmental biology, biochemistry and biophysics. While VRTG students come from two graduate programs and perform their thesis research in a variety of laboratories, they will share common experiences in the coursework, seminar programs, symposia, research meetings and career development forums that comprise the VRTG training program. In addition, students in the Medical Scientist Training Program who are in the graduate research phase of their training will also be eligible for support. Postdoctoral fellows in the Viral Replication Training Program will similarly participate in an organized program of seminars, research presentations and career development forums that will enhance their ability to become productive independent investigators. The training program will be directed by a Steering Committee with responsibilities for selection of high caliber candidates, tracking progress of trainees in the program and providing mentoring for new faculty members in the training of students. The program requests three postdoctoral positions per year as well as four predoctoral slots per year.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI060523-03
Application #
7074756
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
2004-09-01
Project End
2009-05-31
Budget Start
2006-06-01
Budget End
2007-05-31
Support Year
3
Fiscal Year
2006
Total Cost
$145,281
Indirect Cost
Name
Northwestern University at Chicago
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Mandhana, Roli; Horvath, Curt M (2018) Sendai Virus Infection Induces Expression of Novel RNAs in Human Cells. Sci Rep 8:16815
Au-Yeung, Nancy; Horvath, Curt M (2018) Histone H2A.Z Suppression of Interferon-Stimulated Transcription and Antiviral Immunity Is Modulated by GCN5 and BRD2. iScience 6:68-82
Fish, Kamonwan; Sora, Richard P; Schaller, Samantha J et al. (2017) EBV latent membrane protein 2A orchestrates p27kip1 degradation via Cks1 to accelerate MYC-driven lymphoma in mice. Blood 130:2516-2526
Wilcox, Douglas R; Longnecker, Richard (2016) The Herpes Simplex Virus Neurovirulence Factor ?34.5: Revealing Virus-Host Interactions. PLoS Pathog 12:e1005449
Wilcox, Douglas R; Folmsbee, Stephen S; Muller, William J et al. (2016) The Type I Interferon Response Determines Differences in Choroid Plexus Susceptibility between Newborns and Adults in Herpes Simplex Virus Encephalitis. MBio 7:e00437-16
Song, Albert S; Poor, Taylor A; Abriata, Luciano A et al. (2016) Immobilization of the N-terminal helix stabilizes prefusion paramyxovirus fusion proteins. Proc Natl Acad Sci U S A 113:E3844-51
Allen, Shannon A; Carias, Ann M; Anderson, Meegan R et al. (2015) Characterization of the Influence of Semen-Derived Enhancer of Virus Infection on the Interaction of HIV-1 with Female Reproductive Tract Tissues. J Virol 89:5569-80
Wilcox, Douglas R; Muller, William J; Longnecker, Richard (2015) HSV targeting of the host phosphatase PP1? is required for disseminated disease in the neonate and contributes to pathogenesis in the brain. Proc Natl Acad Sci U S A 112:E6937-44
Huffmaster, Nicholas J; Sollars, Patricia J; Richards, Alexsia L et al. (2015) Dynamic ubiquitination drives herpesvirus neuroinvasion. Proc Natl Acad Sci U S A 112:12818-23
Langsfeld, Erika S; Bodily, Jason M; Laimins, Laimonis A (2015) The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes. PLoS Pathog 11:e1005181

Showing the most recent 10 out of 40 publications