The primary objective of the Immunology of Infectious Disease (IID) research training program is to train young scientists in cutting edge microbiology and immunology, to learn to connect these two disciplines, and to do research at the interface of classic microbiology and immunology. Solving the problem of infectious disease, which is responsible for overwhelming morbidity and mortality worldwide, requires scientists well versed in both the microbial and host sides of the equations. The IID training program brings together faculty from throughout the University of Pittsburgh, including the School of Medicine, Graduate School of Public Health and the undergraduate Faculty of Arts and Sciences, to train students and post-docs in a variety of approaches to the study of host-pathogen interactions. Microbes from viruses to bacteria to parasites to fungi are represented and immunologic areas including innate immunity, adaptive immunity virulence strategies for immune evasion and vaccine development. Emphasis is placed on the study of emerging diseases, global infectious diseases, and biodefense organisms. Graduate students in the Molecular Virology and Microbiology and the Immunology graduate programs, under the umbrella of the Interdisciplinary Biomedical Graduate Program, performing dissertation research in the lab of an IID faculty member are eligible for support, once they have advanced to candidacy. Post-doctoral fellows in these labs are also eligible for support. Support for 4 pre-doctoral students each for two years, is requested;post-doctoral awards are for one year, with the opportunity for competitive renewal for a second year. Two post-doctoral slots, at a level of 1-3 years post-degree, per year are requested.

Public Health Relevance

Training students and fellows in the immunology of infectious disease provides the next generation of scientists who will develop treatments and vaccines against diseases caused by bacteria, viruses and other microbes. This training program teaches young scientists both microbiology and immunology and provides a framework for research in both disciplines.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Allergy & Clinical Immunology-1 (AITC)
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Prograis, Lawrence J
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University of Pittsburgh
Schools of Medicine
United States
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Freedman, John C; Shrestha, Archana; McClane, Bruce A (2016) Clostridium perfringens Enterotoxin: Action, Genetics, and Translational Applications. Toxins (Basel) 8:
Morosky, Stefanie; Lennemann, Nicholas J; Coyne, Carolyn B (2016) BPIFB6 Regulates Secretory Pathway Trafficking and Enterovirus Replication. J Virol 90:5098-107
Shrestha, Archana; Hendricks, Matthew R; Bomberger, Jennifer M et al. (2016) Bystander Host Cell Killing Effects of Clostridium perfringens Enterotoxin. MBio 7:
Hendricks, Matthew R; Lashua, Lauren P; Fischer, Douglas K et al. (2016) Respiratory syncytial virus infection enhances Pseudomonas aeruginosa biofilm growth through dysregulation of nutritional immunity. Proc Natl Acad Sci U S A 113:1642-7
Hendricks, Matthew R; Bomberger, Jennifer M (2016) Digging through the Obstruction: Insight into the Epithelial Cell Response to Respiratory Virus Infection in Patients with Cystic Fibrosis. J Virol 90:4258-61
Harris, Katharine G; Coyne, Carolyn B (2015) Unc93b Induces Apoptotic Cell Death and Is Cleaved by Host and Enteroviral Proteases. PLoS One 10:e0141383
Bayer, Avraham; Delorme-Axford, Elizabeth; Sleigher, Christie et al. (2015) Human trophoblasts confer resistance to viruses implicated in perinatal infection. Am J Obstet Gynecol 212:71.e1-8
Li, Jihong; Freedman, John C; McClane, Bruce A (2015) NanI Sialidase, CcpA, and CodY Work Together To Regulate Epsilon Toxin Production by Clostridium perfringens Type D Strain CN3718. J Bacteriol 197:3339-53
Freedman, John C; Theoret, James R; Wisniewski, Jessica A et al. (2015) Clostridium perfringens type A-E toxin plasmids. Res Microbiol 166:264-79
Harris, Katharine G; Morosky, Stefanie A; Drummond, Coyne G et al. (2015) RIP3 Regulates Autophagy and Promotes Coxsackievirus B3 Infection of Intestinal Epithelial Cells. Cell Host Microbe 18:221-32

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