Despite extraordinary progress in HIV research, there remain many critical roadblocks to defining the pathogenesis and optimal treatment of HIV disease. These include identification of correlates of protection from HIV infection and transmission;heterogeneity and pathogenesis of HIV disease progression;latency as an obstacle to eradication;interactions between HIV and the liver, kidney, heart and metabolic systems and their relationship to aging, and short and long term immune restoration in settings where overlapping epidemics of tuberculosis and malaria exist. We have established an HIV translational training program at UCSF to address these research gaps. Our graduates to date have established independent translational research programs, successfully acquired NIH funding, and all have been recruited to full time faculty positions at academic institutions. The objectives of our program are to provide high quality, multidisciplinary training to physician researchers for a career in HIV translational research, under the careful supervision of a small and carefully selected group of patient based and laboratory scientists located on the San Francisco General Hospital campus of UCSF. The program is co-directed by clinic-based (Havlir) and laboratory-based (McCune) physician scientists. The program has the following emphases: (a) hypothesis-driven patient-oriented translational research;(b) co-mentoring by a clinical and a laboratory scientist;(c) training in research methodology, manuscript preparation, and grant writing;and (d) recruitment and retention of women and minorities in the program. Upon completion of the program, we expect our graduates to have achieved the following: (1) to have secured K23, VA career, R21, or R01 funding, (2) to have a track record of publications, and (3) to be well on their way to becoming productive, independent researchers at an academic institution. We strive to train the lead physician HIV scientists of the future and for these leaders to consist of women and men and persons of diverse racial backgrounds.

Public Health Relevance

Twenty three million persons are currently living with HIV, and HIV continues to be a major cause of death and suffering worldwide. Our program supports the training of young scientists that will address high impact research questions aimed at improving our understanding and treatment of HIV.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Sharma, Opendra K
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University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
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Koss, Catherine A; Natureeba, Paul; Nyafwono, Dorcas et al. (2016) Brief Report: Food Insufficiency Is Associated With Lack of Sustained Viral Suppression Among HIV-Infected Pregnant and Breastfeeding Ugandan Women. J Acquir Immune Defic Syndr 71:310-5
Prahl, Mary; Jagannathan, Prasanna; McIntyre, Tara I et al. (2016) Timing of in utero malaria exposure influences fetal CD4 T cell regulatory versus effector differentiation. Malar J 15:497
Lee, Sulggi A; Mefford, Joel A; Huang, Yong et al. (2016) Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans. AIDS 30:1807-15
Marquez, Carina; Chamie, Gabriel; Achan, Jane et al. (2016) Tuberculosis Infection in Early Childhood and the Association with HIV-exposure in HIV-uninfected Children in Rural Uganda. Pediatr Infect Dis J 35:524-9
Koss, Catherine A; Natureeba, Paul; Kwarisiima, Dalsone et al. (2016) Viral Suppression and Retention in Care up to 5 Years after Initiation of Lifelong ART during Pregnancy (Option B+) in Rural Uganda. J Acquir Immune Defic Syndr :
Koss, Catherine A; Natureeba, Paul; Mwesigwa, Julia et al. (2015) Hair concentrations of antiretrovirals predict viral suppression in HIV-infected pregnant and breastfeeding Ugandan women. AIDS 29:825-30
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Lee, Sulggi A; Sinclair, Elizabeth; Jain, Vivek et al. (2014) Low proportions of CD28- CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection. J Infect Dis 210:374-82
Eriksson, Emily M; Liegler, Teri; Keh, Chris E et al. (2014) Newly Exerted T Cell Pressures on Mutated Epitopes following Transmission Help Maintain Consensus HIV-1 Sequences. PLoS One 10:e0120787
Koss, Catherine A; Natureeba, Paul; Plenty, Albert et al. (2014) Risk factors for preterm birth among HIV-infected pregnant Ugandan women randomized to lopinavir/ritonavir- or efavirenz-based antiretroviral therapy. J Acquir Immune Defic Syndr 67:128-35

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