Despite extraordinary progress in HIV research, there remain many critical roadblocks to defining the pathogenesis and optimal treatment of HIV disease. These include identification of correlates of protection from HIV infection and transmission;heterogeneity and pathogenesis of HIV disease progression;latency as an obstacle to eradication;interactions between HIV and the liver, kidney, heart and metabolic systems and their relationship to aging, and short and long term immune restoration in settings where overlapping epidemics of tuberculosis and malaria exist. We have established an HIV translational training program at UCSF to address these research gaps. Our graduates to date have established independent translational research programs, successfully acquired NIH funding, and all have been recruited to full time faculty positions at academic institutions. The objectives of our program are to provide high quality, multidisciplinary training to physician researchers for a career in HIV translational research, under the careful supervision of a small and carefully selected group of patient based and laboratory scientists located on the San Francisco General Hospital campus of UCSF. The program is co-directed by clinic-based (Havlir) and laboratory-based (McCune) physician scientists. The program has the following emphases: (a) hypothesis-driven patient-oriented translational research;(b) co-mentoring by a clinical and a laboratory scientist;(c) training in research methodology, manuscript preparation, and grant writing;and (d) recruitment and retention of women and minorities in the program. Upon completion of the program, we expect our graduates to have achieved the following: (1) to have secured K23, VA career, R21, or R01 funding, (2) to have a track record of publications, and (3) to be well on their way to becoming productive, independent researchers at an academic institution. We strive to train the lead physician HIV scientists of the future and for these leaders to consist of women and men and persons of diverse racial backgrounds.

Public Health Relevance

Twenty three million persons are currently living with HIV, and HIV continues to be a major cause of death and suffering worldwide. Our program supports the training of young scientists that will address high impact research questions aimed at improving our understanding and treatment of HIV.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI060530-09
Application #
8475535
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Sharma, Opendra K
Project Start
2004-07-01
Project End
2015-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
9
Fiscal Year
2013
Total Cost
$397,369
Indirect Cost
$28,435
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Lee, Sulggi A; Sinclair, Elizabeth; Jain, Vivek et al. (2014) Low proportions of CD28- CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection. J Infect Dis 210:374-82
Koss, Catherine A; Natureeba, Paul; Plenty, Albert et al. (2014) Risk factors for preterm birth among HIV-infected pregnant Ugandan women randomized to lopinavir/ritonavir- or efavirenz-based antiretroviral therapy. J Acquir Immune Defic Syndr 67:128-35
Lee, Sulggi A; Sinclair, Elizabeth; Hatano, Hiroyu et al. (2014) Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging. PLoS One 9:e89444
Christopoulos, Katerina A; Zetola, Nicola M; Klausner, Jeffrey D et al. (2013) Leveraging a rapid, round-the-clock HIV testing system to screen for acute HIV infection in a large urban public medical center. J Acquir Immune Defic Syndr 62:e30-8
Kakuru, Abel; Jagannathan, Prasanna; Arinaitwe, Emmanuel et al. (2013) The effects of ACT treatment and TS prophylaxis on Plasmodium falciparum gametocytemia in a cohort of young Ugandan children. Am J Trop Med Hyg 88:736-43
Eriksson, Emily M; Milush, Jeffrey M; Ho, Emily L et al. (2012) Expansion of CD8+ T cells lacking Sema4D/CD100 during HIV-1 infection identifies a subset of T cells with decreased functional capacity. Blood 119:745-55
Christopoulos, Katerina A; Weiser, Sheri D; Koester, Kimberly A et al. (2012) Understanding patient acceptance and refusal of HIV testing in the emergency department. BMC Public Health 12:3
Christopoulos, Katerina A; Koester, Kim; Weiser, Sheri et al. (2011) A comparative evaluation of the process of developing and implementing an emergency department HIV testing program. Implement Sci 6:30
Jain, Vivek; Sucupira, Maria C; Bacchetti, Peter et al. (2011) Differential persistence of transmitted HIV-1 drug resistance mutation classes. J Infect Dis 203:1174-81
Christopoulos, Katerina A; Das, Moupali; Colfax, Grant N (2011) Linkage and retention in HIV care among men who have sex with men in the United States. Clin Infect Dis 52 Suppl 2:S214-22

Showing the most recent 10 out of 22 publications