Despite extraordinary progress in HIV research, there remain many critical roadblocks to defining the pathogenesis and optimal treatment of HIV disease. These include identification of correlates of protection from HIV infection and transmission;heterogeneity and pathogenesis of HIV disease progression;latency as an obstacle to eradication;interactions between HIV and the liver, kidney, heart and metabolic systems and their relationship to aging, and short and long term immune restoration in settings where overlapping epidemics of tuberculosis and malaria exist. We have established an HIV translational training program at UCSF to address these research gaps. Our graduates to date have established independent translational research programs, successfully acquired NIH funding, and all have been recruited to full time faculty positions at academic institutions. The objectives of our program are to provide high quality, multidisciplinary training to physician researchers for a career in HIV translational research, under the careful supervision of a small and carefully selected group of patient based and laboratory scientists located on the San Francisco General Hospital campus of UCSF. The program is co-directed by clinic-based (Havlir) and laboratory-based (McCune) physician scientists. The program has the following emphases: (a) hypothesis-driven patient-oriented translational research;(b) co-mentoring by a clinical and a laboratory scientist;(c) training in research methodology, manuscript preparation, and grant writing;and (d) recruitment and retention of women and minorities in the program. Upon completion of the program, we expect our graduates to have achieved the following: (1) to have secured K23, VA career, R21, or R01 funding, (2) to have a track record of publications, and (3) to be well on their way to becoming productive, independent researchers at an academic institution. We strive to train the lead physician HIV scientists of the future and for these leaders to consist of women and men and persons of diverse racial backgrounds.

Public Health Relevance

Twenty three million persons are currently living with HIV, and HIV continues to be a major cause of death and suffering worldwide. Our program supports the training of young scientists that will address high impact research questions aimed at improving our understanding and treatment of HIV.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI060530-09
Application #
8475535
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Sharma, Opendra K
Project Start
2004-07-01
Project End
2015-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
9
Fiscal Year
2013
Total Cost
$397,369
Indirect Cost
$28,435
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Clemenzi-Allen, Angelo; Geng, Elvin; Christopoulos, Katerina et al. (2018) Degree of Housing Instability Shows Independent ""Dose-Response"" With Virologic Suppression Rates Among People Living With Human Immunodeficiency Virus. Open Forum Infect Dis 5:ofy035
Mody, Aaloke; Roy, Monika; Sikombe, Kombatende et al. (2018) Improved Retention With 6-Month Clinic Return Intervals for Stable Human Immunodeficiency Virus-Infected Patients in Zambia. Clin Infect Dis 66:237-243
McDonald, Chloe R; Conroy, Andrea L; Gamble, Joel L et al. (2018) Estradiol Levels Are Altered in Human Immunodeficiency Virus-Infected Pregnant Women Randomized to Efavirenz-Versus Lopinavir/Ritonavir-Based Antiretroviral Therapy. Clin Infect Dis 66:428-436
Katrak, Shereen; Nayebare, Patience; Rek, John et al. (2018) Clinical consequences of submicroscopic malaria parasitaemia in Uganda. Malar J 17:67
Spinelli, Matthew A; Frongillo, Edward A; Sheira, Lila A et al. (2017) Food Insecurity is Associated with Poor HIV Outcomes Among Women in the United States. AIDS Behav 21:3473-3477
Brondfield, Max N; Reid, Michael J A; Rutishauser, Rachel L et al. (2017) Disseminated Acanthamoeba infection in a heart transplant recipient treated successfully with a miltefosine-containing regimen: Case report and review of the literature. Transpl Infect Dis 19:
Prahl, Mary; Jagannathan, Prasanna; McIntyre, Tara I et al. (2017) Sex Disparity in Cord Blood FoxP3+ CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero. Open Forum Infect Dis 4:ofx022
Brown, Lillian; Langelier, Charles; Reid, Michael J A et al. (2017) Antimicrobial Resistance: A Call to Action! Clin Infect Dis 64:106-107
Katrak, Shereen; Murphy, Maxwell; Nayebare, Patience et al. (2017) Performance of Loop-Mediated Isothermal Amplification for the Identification of Submicroscopic Plasmodium falciparum Infection in Uganda. Am J Trop Med Hyg 97:1777-1781
Kajubi, R; Huang, L; Jagannathan, P et al. (2017) Antiretroviral Therapy With Efavirenz Accentuates Pregnancy-Associated Reduction of Dihydroartemisinin-Piperaquine Exposure During Malaria Chemoprevention. Clin Pharmacol Ther 102:520-528

Showing the most recent 10 out of 53 publications