The University of Pittsburgh's Pitt AIDS Research Training (PART) Program will be administered under the leadership of the Program Director, Dr. Todd Reinhart, with assistance from an internal steering committee and an external advisory committee. The current program has been training predoctoral students for four years and during this fifth year of training, we are seeking to renew the NIH support for the program. During this time we have trained or are continuing to train a total of 15 PhD students for periods of one to two years each. This proposal is for support to allow the PART Program to build upon the success of the first period of the award and continue to support the predoctoral training of HIV/AIDS researchers at the University of Pittsburgh. Rigorous training in both the process and content of HIV/AIDS research will be maintained and expanded. Continued efforts will be made to recruit and train the best and brightest students in the laboratories of our productive HIV/AIDS faculty members. These faculty members span multiple cross-cutting programs with appointments in mostly two departments: (1) the Department of Infectious Diseases &Microbiology in the Graduate School of Public Health;and (2) the Department of Microbiology &Molecular Genetics in the University of Pittsburgh School of Medicine. The majority of students will continue to be registered either in the IDM PhD program or in the Molecular Virology and Microbiology PhD program within the broader School of Medicine Interdisciplinary Biomedical Graduate Program. In the next training period, the PART Program will give specific attention to developing the leadership skills of PART trainees through the formal study of leadership theory and practice. Preparing the future generation of scientist requires not only an understanding of how to perform research, but the critical social contexts in which this occurs. This social context for these high-quality trainees will ultimately involve leadership positions and there is a tremendous gap in the extent to which researchers are being taught about leadership. With emphasis on high-quality research, with a foundation of excellent didactic coursework, and in a world-class HIV/AIDS research environment, PART trainees will be prepared for leadership roles at the postdoctoral and independent investigator levels.
The HIV/AIDS epidemic continues and solid, innovative, and well-led research is required to continue to face this challenge. The PART Program will continue to train PhD level investigators in a multi-disciplinary environment so that they are prepared to perform and lead basic HIV/AIDS research and contribute to the fight against this infectious disease.
|Lepone, Lauren M; Rappocciolo, Giovanna; Piazza, Paolo A et al. (2017) Regulatory T Cell Effect on CD8+ T Cell Responses to Human Herpesvirus 8 Infection and Development of Kaposi's Sarcoma. AIDS Res Hum Retroviruses 33:668-674|
|Swan, Zachary D; Bouwer, Anthea L; Wonderlich, Elizabeth R et al. (2017) Persistent accumulation of gut macrophages with impaired phagocytic function correlates with SIV disease progression in macaques. Eur J Immunol 47:1925-1935|
|Smith, Kellie N; Mailliard, Robbie B; Piazza, Paolo A et al. (2016) Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells. MBio 7:|
|Policicchio, Benjamin B; Xu, Cuiling; Brocca-Cofano, Egidio et al. (2016) Multi-dose Romidepsin Reactivates Replication Competent SIV in Post-antiretroviral Rhesus Macaque Controllers. PLoS Pathog 12:e1005879|
|He, Tianyu; Brocca-Cofano, Egidio; Policicchio, Benjamin B et al. (2016) Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes. J Immunol 197:4535-4539|
|Zerbato, Jennifer M; Serrao, Erik; Lenzi, Gina et al. (2016) Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro. J Virol 90:8059-73|
|Swan, Zachary D; Wonderlich, Elizabeth R; Barratt-Boyes, Simon M (2016) Macrophage accumulation in gut mucosa differentiates AIDS from chronic SIV infection in rhesus macaques. Eur J Immunol 46:446-54|
|Zaccard, C R; Rinaldo, C R; Mailliard, R B (2016) Linked in: immunologic membrane nanotube networks. J Leukoc Biol 100:81-94|
|Smith, Steven J; Pauly, Gary T; Akram, Aamir et al. (2016) Rilpivirine and Doravirine Have Complementary Efficacies Against NNRTI-Resistant HIV-1 Mutants. J Acquir Immune Defic Syndr 72:485-91|
|Smith, Steven J; Pauly, Gary T; Akram, Aamir et al. (2016) Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants. Retrovirology 13:11|
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