There is an urgent need to increase the number of veterinarian-scientists with expertise in infectious disease research. Over 60% of all infectious diseases of animals can also affect humans, and incidences of new, emerging zoonotic infectious diseases are increasing. Three reports by the National Research Council point out that there is an unprecedented decline in interest in public health and biomedical research by veterinarians, and argues that society's need to protect against these threats is outgrowing the veterinary knowledge base. Our program seeks to directly address this national need through our V.M.D.-Ph.D. training program in infectious disease-related research which has a strong history of generating scientists in academia, industry, and government. This program is contained within the umbrella of our larger V.M.D.-Ph.D. program which has a 43 year track record of success. Our training program includes focused activities on infectious diseases including as a global heath course, a zoonotic and infectious disease discussion group, infectious disease-related seminars, annual infectious disease-related retreats, and externships at a government public health agency. This is coupled with infectious disease-related veterinary and graduate didactic education, rigorous biomedical Ph.D. thesis research, and veterinary clinical training. The program is further supported by synergistic activities provided by the large V.M.D.-Ph.D. and MD-Ph.D. programs. Students receive V.M.D. training at the Penn School of Veterinary Medicine, and Ph.D. training within one of the Penn Biomedical Graduate Groups devoted to research in infectious disease-related research (1) Microbiology, Virology, and Parasitology, 2) Immunology, or 3) Epidemiology and Biostatistics. Our program brings together 42 faculty trainers with established research experience in the above disciplines. These faculty have a rich history of predoctoral and postdoctoral training and have trained over 500 individuals in the past decade. Throughout the program, V.M.D. and Ph.D. curricula are interdigitated and programs are in place to bridge the two training programs to provide maximal synergy. Extensive oversight and advising systems are also in place to provide an efficient and well- structured program. Our tracking data indicate that over 80% of alumni are in research careers. In summary, we seek to address a pressing national need for more veterinarian-scientists through our V.M.D.-Ph.D. program in infectious disease-related research.

Public Health Relevance

As biomedical research advances and the threat of infectious diseases expands, there is a greater need than ever for veterinarians who are trained as investigators working at the intersection between medicine and science. The goal of the Penn V.M.D.-Ph.D. training program in infectious disease-related research is to identify, train and mentor a diverse group of outstanding men and women, and to help them become scholars and leaders of biomedical research in infectious disease-related topics.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI070077-07
Application #
8667391
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Program Officer
Robbins, Christiane M
Project Start
2006-07-01
Project End
2018-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
7
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Madara, Jonathan J; Han, Ziying; Ruthel, Gordon et al. (2015) The multifunctional Ebola virus VP40 matrix protein is a promising therapeutic target. Future Virol 10:537-546
Han, Ziying; Madara, Jonathan J; Herbert, Andrew et al. (2015) Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention. PLoS Pathog 11:e1005220
Breed, Matthew W; Elser, Samra E; Torben, Workineh et al. (2015) Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif. J Virol 89:10156-75
Patel, Nikkita Gunvant; Rorres, Chris; Joly, Damien O et al. (2015) Quantitative methods of identifying the key nodes in the illegal wildlife trade network. Proc Natl Acad Sci U S A 112:7948-53
Han, Ziying; Madara, Jonathan J; Liu, Yuliang et al. (2015) ALIX Rescues Budding of a Double PTAP/PPEY L-Domain Deletion Mutant of Ebola VP40: A Role for ALIX in Ebola Virus Egress. J Infect Dis 212 Suppl 2:S138-45
Redding, L E; Cubas-Delgado, F; Sammel, M D et al. (2014) Comparison of two methods for collecting antibiotic use data on small dairy farms. Prev Vet Med 114:213-22
Redding, L E; Cubas-Delgado, F; Sammel, M D et al. (2014) The use of antibiotics on small dairy farms in rural Peru. Prev Vet Med 113:88-95
Bukh, Irene; Calcedo, Roberto; Roy, Soumitra et al. (2014) Increased mucosal CD4+ T cell activation in rhesus macaques following vaccination with an adenoviral vector. J Virol 88:8468-78
Brinkley, Catherine; Vitiello, Domenic (2014) From Farm to Nuisance: Animal Agriculture and the Rise of Planning Regulation. J Plan Hist 13:113-135
Li, Yang; Myers, Jaclyn L; Bostick, David L et al. (2013) Immune history shapes specificity of pandemic H1N1 influenza antibody responses. J Exp Med 210:1493-500

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