This application is a renewal for a pre-doctoral training program in Immunity and Infectious Disease at The Rockefeller University, an institution with a rich history in these areas. The Immunity and Infectious Disease Training Program is a specialized unit of the Ph.D. program at Rockefeller, and is specifically designed for immunology and infectious disease training. The training program includes required coursework, rotations, and extensive research opportunities. The 17 faculty trainers are accomplished scientists, including 4 members of the US National Academy of Sciences, with a shared interest and experience in graduate education. The faculty has expertise in a very broad range of immunology and infectious disease, and the program encourages trainees to perform collaborative work in various areas with different faculty. We propose to support 4 pre-doctoral trainees during years 1-3 of graduate study. The applicant pool is outstanding, including a large number of students with accomplished undergraduate records, extensive research experience and a strong interest in immunology and infectious disease. Trainees would be mentored by the Program Director~ a Program Advisory Committee of selected faculty for general curriculum and research advice~ and a Faculty Advisory Committee, specifically designed for each trainee to provide detailed experimental guidance. Finally, the University provides extensive support for the graduate program in general, which benefits the Immunity and Infectious Disease training program. The confluence of these attributes defines a specific training program that would equip trainees with the educational background, analytical abilities, and experimental expertise to forge future advances in immunology and infectious disease.

Public Health Relevance

This training grant supports research and education that is directly relevant t public health, including clinically relevant coursework and research opportunities in areas such as the development of treatments for cancer and new vaccines for HIV and Hepatitis C.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI070084-08
Application #
8839706
Study Section
Allergy, Immunology, and Transplantation Research Committee (AITC)
Program Officer
Robbins, Christiane M
Project Start
2006-07-01
Project End
2016-04-30
Budget Start
2015-05-01
Budget End
2016-04-30
Support Year
8
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Rockefeller University
Department
Microbiology/Immun/Virology
Type
Graduate Schools
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
Lorenzi, Julio C C; Cohen, Yehuda Z; Cohn, Lillian B et al. (2016) Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA. Proc Natl Acad Sci U S A 113:E7908-E7916
Escolano, Amelia; Steichen, Jon M; Dosenovic, Pia et al. (2016) Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice. Cell 166:1445-1458.e12
Sujino, Tomohisa; London, Mariya; Hoytema van Konijnenburg, David P et al. (2016) Tissue adaptation of regulatory and intraepithelial CD4? T cells controls gut inflammation. Science 352:1581-6
Cohn, Lillian B; Silva, Israel T; Oliveira, Thiago Y et al. (2015) HIV-1 integration landscape during latent and active infection. Cell 160:420-32
Klein, Florian; Nogueira, Lilian; Nishimura, Yoshiaki et al. (2014) Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants. J Exp Med 211:2361-72
Bikard, David; Euler, Chad W; Jiang, Wenyan et al. (2014) Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials. Nat Biotechnol 32:1146-50
Goldberg, Gregory W; Jiang, Wenyan; Bikard, David et al. (2014) Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting. Nature 514:633-7
Utter, Bryan; Deutsch, Douglas R; Schuch, Raymond et al. (2014) Beyond the chromosome: the prevalence of unique extra-chromosomal bacteriophages with integrated virulence genes in pathogenic Staphylococcus aureus. PLoS One 9:e100502
Halper-Stromberg, Ariel; Lu, Ching-Lan; Klein, Florian et al. (2014) Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice. Cell 158:989-999
Zhou, Tongqing; Zhu, Jiang; Wu, Xueling et al. (2013) Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies. Immunity 39:245-58