Transplantation is a rapidly-expanding, challenging area of clinical medicine with great potential for the cure of many human diseases. This field provides exciting opportunities for productive interaction between basic scientists and clinicians. The University of Pittsburgh's Starzl Transplantation Institute and Departments in the School of Medicine provide a unique academic environment, conducive to the comprehensive, broad-based training of young basic scientists and physicians in transplantation biology, with an emphasis on immunology and cell and molecular pathology. Our Interdisciplinary Transplantation Biology Training Program trains graduate and postdoctoral researchers to help ensure that highly-trained investigators are available to assume leadership roles in academia, industry and government-affiliated research. Participating faculty with diverse but complementary research interests, a successful record of productive collaboration and a commitment to training young investigators, impart skills in transplantation biology. Most aspects are covered, including expertise in immunogenetics, aspects of ischemia-reperfusion injury, antigen-presenting cell, T and B cell biology, tolerance induction, liver immunology, biology of transplant infectious disease, chronic rejection, composite tissue transplantation, evolution of allo- and xenorecognition, xenotransplantation and novel therapeutic immunosuppressive agents/regimens. A unique feature of the Training Program is that investigations range from those in invertebrates and rodents to non-human primates and humans. The principal goal of this Training Program is to produce outstanding, potentially independent investigators, able to address fundamental questions in transplantation biology and equipped with appropriate survival and career development skills. Pre-doctoral trainees are selected from graduate students enrolled in the Interdisciplinary Biomedical Graduate Training Program at the University of Pittsburgh School of Medicine, who express interest in pursuing PhD research in transplantation biology. Based on the successes achieved during the initial funding period of this Training Grant and the availability of well-qualified applicants, support is requested for 3 pre-doctoral trainees in the 06 year and for 3 trainees in subsequent years, distributed between students in their 1st, 2nd, 3rd or 4th year of research. Postdoctoral trainees with MD, PhD, or MD/PhD degrees will be selected based on their outstanding potential and will be supported for 2 years. Support is requested for 3 postdoctoral trainees in the 06 year, and for 3 trainees in subsequent years.

Public Health Relevance

Training students and fellows in transplantation biology provides the next generation of scientists who will improve understanding of transplant rejection and acceptance, and develop treatments to reduce patients'dependence on immunosuppressive drugs. This training program teaches young scientists the necessary skills to develop research careers in transplantation with a strong emphasis on immunology and cell and molecular biology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI074490-06
Application #
8337484
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
2007-09-01
Project End
2017-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
6
Fiscal Year
2012
Total Cost
$296,524
Indirect Cost
$19,203
Name
University of Pittsburgh
Department
Surgery
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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Ezzelarab, Mohamed B; Ekser, Burcin; Isse, Kumiko et al. (2014) Increased soluble CD154 (CD40 ligand) levels in xenograft recipients correlate with the development of de novo anti-pig IgG antibodies. Transplantation 97:502-8
Zhou, Huidong; Iwase, Hayato; Wolf, Roman F et al. (2014) Are there advantages in the use of specific pathogen-free baboons in pig organ xenotransplantation models? Xenotransplantation 21:287-90
Iwase, Hayato; Ezzelarab, Mohamed B; Ekser, Burcin et al. (2014) The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options. Xenotransplantation 21:201-20
Yoshida, O; Kimura, S; Dou, L et al. (2014) DAP12 deficiency in liver allografts results in enhanced donor DC migration, augmented effector T cell responses and abrogation of transplant tolerance. Am J Transplant 14:1791-805
Walch, Jeffrey M; Lakkis, Fadi G (2014) T-cell migration to vascularized organ allografts. Curr Opin Organ Transplant 19:28-32
Rosborough, Brian R; Raich-Regue, Dalia; Turnquist, Heth R et al. (2014) Regulatory myeloid cells in transplantation. Transplantation 97:367-79
Stenger, Elizabeth O; Rosborough, Brian R; Mathews, Lisa R et al. (2014) IL-12hi rapamycin-conditioned dendritic cells mediate IFN-ýý-dependent apoptosis of alloreactive CD4+ T cells in vitro and reduce lethal graft-versus-host disease. Biol Blood Marrow Transplant 20:192-201
Rosborough, B R; Raïch-Regué, D; Liu, Q et al. (2014) Adenosine triphosphate-competitive mTOR inhibitors: a new class of immunosuppressive agents that inhibit allograft rejection. Am J Transplant 14:2173-80
Boyette, Lisa B; Creasey, Olivia A; Guzik, Lynda et al. (2014) Human bone marrow-derived mesenchymal stem cells display enhanced clonogenicity but impaired differentiation with hypoxic preconditioning. Stem Cells Transl Med 3:241-54

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