We request renewed support for a postdoctoral training program focused on molecular mechanisms of immunologic tolerance and autoimmunity. The application comes from a highly interactive faculty centered in the Integrated Department of Immunology whose faculty is strongly focused on B and T cell development, antigen recognition, repertoire development, silencing by editing, deletion and anergy, and understanding autoimmunity. The Integrated Department of Immunology is comprised of 65 faculty (primary and secondary) from three institutions: the National Jewish Health, The Barbara Davis Center for Childhood Diabetes (BDC) and The University of Colorado School of Medicine. Nearly half of the 20 training faculty have been recruited to the Department since its inception in 1999, and all training faculty are supported by NIH RO1 grants on which they are Principal Investigator. We request stipend support for 4 fellows who will train in laboratories of their choosing whose research is focused of immune tolerance and autoimmunity. The fellows will participate in regularly scheduled journal clubs, research in progress seminars, formal seminars and courses, e.g. on ethics and survival skills in science, and their progress will be monitored by a training oversight committee (TOC). Trainees will be appointed for one year and reappointed only if they are judged by the TOC to be making significant progress. Our goal is to provide fellows with comprehensive knowledge of immune tolerance and mouse models of autoimmunity, and sufficient understanding of clinical autoimmunity to enable their development of productive clinical collaborative ties for translation of research. The Program Director is Dr. John Cambier, Ida and Cecil Green Distinguished Professor and Chairman of the Integrated Department of Immunology. Dr. Cambier is an expert in B cell signaling, activation and anergy, and has trained in excess of 60 graduate students and postdoctoral fellows. The training program has available superb research facilities and the faculty, are interactive in both training and research. Although the Denver immunology community has been training pre- and postdoctoral fellows for over 30 years, formation of the Integrated Department of Immunology and hiring of new faculty has provided a strongly uniting influence, and injected new excitement and vitality into our educational and research activities. This training program is a central focus of that vitality.

Public Health Relevance

Autoimmunity is a constellation of >80 diseases estimated to afflict 20% of Americans. Among the top 10 causes of death, these diseases exact an enormous social and economic toll. Autoimmunity is estimated to have an economic impact of hundreds of billions of dollars per year. Knowledge of the molecular mechanisms that maintain immunologic tolerance and how they fail in autoimmunity is sadly lacking. Thus, we request renewal of T32 AI074491 to support stipends of four post-doctoral fellows while they receive research training across the continuum from repertoire development and the molecular basis of immune tolerance, to clinical autoimmunity.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Transplantation Biology &Immunology-2 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
National Jewish Health
United States
Zip Code
Swanson, Cristina L; Pelanda, Roberta; Torres, Raul M (2013) Division of labor during primary humoral immunity. Immunol Res 55:277-86
Abdul-Sater, Ali A; Tattoli, Ivan; Jin, Lei et al. (2013) Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome. EMBO Rep 14:900-6
Jin, Lei; Getahun, Andrew; Knowles, Heather M et al. (2013) STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration. J Immunol 190:2835-43
Rubtsova, Kira; Rubtsov, Anatoly V; van Dyk, Linda F et al. (2013) T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance. Proc Natl Acad Sci U S A 110:E3216-24
Baker, Rocky L; Mallevaey, Thierry; Gapin, Laurent et al. (2012) T cells interact with T cells via CD40-CD154 to promote autoimmunity in type 1 diabetes. Eur J Immunol 42:672-80
Schmidt, Rebecca L; Filak, Holly C; Lemon, Jack D et al. (2011) A LysM and SH3-domain containing region of the Listeria monocytogenes p60 protein stimulates accessory cells to promote activation of host NK cells. PLoS Pathog 7:e1002368