This is a competing renewal application for a postdoctoral T32 training grant in laboratory-based transplantation biology. Solid organ transplantation is the ideal therapy for end stage failure due to kidney, heart, liver, and lung, disease, among other organs. Despite significant improvements in the care of all solid organ transplant recipients long term allograft survival remains suboptimal. Analogously, bone marrow transplantation is an effective therapy for hematologic malignancies, but acute (and chronic) graft versus host disease occurs commonly and causes significant morbidity. Moreover, while scientific progress has increased knowledge, the causes of graft loss (and GVHD) are only partially understood, reliable tolerance induction protocols remain elusive, and the ability to translate what information is available into useful diagnostic, preventive and treatment modalities in patients has been limited. To continue to improve transplant outcomes in humans and as a consequence, improve the long term health of all transplant recipients, research in transplantation must remain cutting edge, and the next generation of physicians/scientists must have the appropriate knowledge base and skills to continue to drive the field forward. Because transplantation is a cross disciplinary field involving multiple medical, surgical, and basic pathology/immunology themes, we believe an effective training environment must be cross-disciplinary. Thus, the objective of this training program is to use an interactive, collaborative, cross-disciplinary approach to train talented young physician-scientists (MD and MD PhD) or PhD-scientists for a successful career in laboratory based, investigative, transplantation immunobiology research. In support of the renewal application, the initial funding period of this training program has been successful in accomplishing the key aim of fostering the careers of trainees in transplantation, in particular, underrepresented minorities. Our rationales for submitting this competitive renewal grant application include: 1) the continued need for improving outcomes following solid organ or hematopoietic cell transplantation, 2) our strong desire to continue to have an impact on the education of future investigators in the field of transplantation, and 3) our belief that the proposed group of trainers will offer diverse basic and translational scientific opportunities within the field of transplantation supported by an established infrastructure designed for training and nurturing young transplant researchers toward independence. We have a diverse and well funded faculty with an interest in transplantation and a strong pool of trainees that includes significant numbers of underrepresented minorities. The program is overseen by P Heeger, who is well recognized and accomplished clinical and basic physician scientist with significant postdoctoral training, and educational, experience. The program is designed to support laboratory based training by individual mentors performing research in transplantation medicine/biology. The cross disciplinary program is supplemented with significant didactic training in transplantation science, grant writing, manuscript preparation and career development so as to optimize the development of independent academic researchers in the transplant field.

Public Health Relevance

In order to continue to improve clinical outcomes following organ transplantation there is an ongoing need to train physicians and scientists who will move the field of transplantation forward. This proposed training program will draw MD, PhD and MD/PhD candidates into a comprehensive training environment to teach them cutting edge science in the transplantation field so as to meet this need. The program is directly relevant to public health in that its goal is to train the next generation of leaders in transplantation medicie and science and thus be able to prolong the survival and function of transplanted organs and improve patient health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI078892-06
Application #
8551124
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
2008-08-01
Project End
2018-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
6
Fiscal Year
2013
Total Cost
$190,888
Indirect Cost
$13,894
Name
Icahn School of Medicine at Mount Sinai
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Warren, Kristi J; Iwami, Daiki; Harris, Donald G et al. (2014) Laminins affect T cell trafficking and allograft fate. J Clin Invest 124:2204-18
Kalache, Safa; Lakhani, Parth; Heeger, Peter S (2014) Effects of preexisting autoimmunity on heart graft prolongation after donor-specific transfusion and anti-CD154. Transplantation 97:12-9
Noriega, Vanessa M; Haye, Kester K; Kraus, Thomas A et al. (2014) Human cytomegalovirus modulates monocyte-mediated innate immune responses during short-term experimental latency in vitro. J Virol 88:9391-405
Reid-Adam, J; Yang, N; Song, Y et al. (2013) Immunosuppressive effects of the traditional Chinese herb Qu Mai on human alloreactive T cells. Am J Transplant 13:1159-67
Burrell, B E; Bromberg, J S (2012) Fates of CD4+ T cells in a tolerant environment depend on timing and place of antigen exposure. Am J Transplant 12:576-89
Noriega, Vanessa M; Hesse, Julia; Gardner, Thomas J et al. (2012) Human cytomegalovirus US3 modulates destruction of MHC class I molecules. Mol Immunol 51:245-53
Kalache, Safa; Dinavahi, Rajani; Pinney, Sean et al. (2011) Anticardiac myosin immunity and chronic allograft vasculopathy in heart transplant recipients. J Immunol 187:1023-30
Sugar, Istvan P; Gonzalez-Lergier, Joanna; Sealfon, Stuart C (2011) Improved compensation in flow cytometry by multivariable optimization. Cytometry A 79:356-60
Burrell, Bryna E; Bishop, D Keith (2010) Th17 cells and transplant acceptance. Transplantation 90:945-8