This is a revised application for support of a predoctoral training program in Virology at the University of Minnesota. The specific need for a training grant in the area of Virology has arisen from the efforts of an energetic and dynamic group of University of Minnesota faculty, who are all members of the Institute for Molecular Virology (IMV). The primary goal of this training grant application is to attract and educate predoctoral students with an interest in pursuing an independent research career. The 12 preceptors involved in this training program represent a highly enthusiastic mixture of senior and more junior faculty members that are strongly committed to the training of predoctoral students in Virology. All of the participating preceptors have trained and graduated at least 1 Ph.D. student and all have current federal grant support for their research programs. Several of the preceptors are accomplished leaders in their research areas, while others are rising stars. The overarching research theme of the training program is virus-host cell interactions, which encompasses 1) mechanisms of viral replication and restriction and 2) molecular pathogenesis. Predoctoral students who seek training in Virology enroll in the Microbiology, Immunology and Cancer Biology (MlCaB) Graduate Program or the Molecular, Cellular and Structural Biology (MCSB) Graduate Program. Students will take graduate level courses in cell and molecular biology and obtain rigorous and intensive coursework in Virology. Predoctoral students will be chosen for this training program from a pool of MICaB and MCSB students, typically in their second or third year of training, by a competitive selection process. Students will be supported for up to 3 years. Students supported by the training program will participate in IMV research-in-progress meetings, IMV subgroup meetings, a virology journal club, an IMV lecture series, and the annual IMV Symposium. Trainees are expected to complete their dissertation research in 4-5 years, publish their work in high-profile virology journals, and pursue postdoctoral training at leading research institutions.

Public Health Relevance

This training program is relevant to public health as it supports career development of young scientists who will help develop new antiviral drugs and vaccines for viral diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI083196-05
Application #
8666706
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Program Officer
Robbins, Christiane M
Project Start
2010-07-01
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Dentistry
Type
Schools of Dentistry/Oral Hygn
DUNS #
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Richards, Christopher M; Li, Ming; Perkins, Angela L et al. (2017) Reassessing APOBEC3G Inhibition by HIV-1 Vif-Derived Peptides. J Mol Biol 429:88-96
Molan, Amy M; Hanson, Heather M; Chweya, Cynthia M et al. (2017) APOBEC3B lysine residues are dispensable for DNA cytosine deamination, HIV-1 restriction, and nuclear localization. Virology 511:74-81
Martin, Jessica L; Mendonça, Luiza M; Angert, Isaac et al. (2017) Disparate Contributions of Human Retrovirus Capsid Subdomains to Gag-Gag Oligomerization, Virus Morphology, and Particle Biogenesis. J Virol 91:
Tschida, Barbara R; Temiz, Nuri A; Kuka, Timothy P et al. (2017) Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors. Cancer Res 77:6576-6588
Meissner, Morgan E; Mendonça, Luiza M; Zhang, Wei et al. (2017) Polymorphic Nature of Human T-Cell Leukemia Virus Type 1 Particle Cores as Revealed through Characterization of a Chronically Infected Cell Line. J Virol 91:
Rawson, Jonathan M O; Gohl, Daryl M; Landman, Sean R et al. (2017) Single-Strand Consensus Sequencing Reveals that HIV Type but not Subtype Significantly Impacts Viral Mutation Frequencies and Spectra. J Mol Biol 429:2290-2307
Maldonado, José O; Angert, Isaac; Cao, Sheng et al. (2017) Perturbation of Human T-Cell Leukemia Virus Type 1 Particle Morphology by Differential Gag Co-Packaging. Viruses 9:
Maldonado, José O; Cao, Sheng; Zhang, Wei et al. (2016) Distinct Morphology of Human T-Cell Leukemia Virus Type 1-Like Particles. Viruses 8:
Martin, Jessica L; Cao, Sheng; Maldonado, Jose O et al. (2016) Distinct Particle Morphologies Revealed through Comparative Parallel Analyses of Retrovirus-Like Particles. J Virol 90:8074-84
Martin, Jessica L; Maldonado, José O; Mueller, Joachim D et al. (2016) Molecular Studies of HTLV-1 Replication: An Update. Viruses 8:

Showing the most recent 10 out of 57 publications