This is a revised application for support of a predoctoral training program in Virology at the University of Minnesota. The specific need for a training grant in the area of Virology has arisen from the efforts of an energetic and dynamic group of University of Minnesota faculty, who are all members of the Institute for Molecular Virology (IMV). The primary goal of this training grant application is to attract and educate predoctoral students with an interest in pursuing an independent research career. The 12 preceptors involved in this training program represent a highly enthusiastic mixture of senior and more junior faculty members that are strongly committed to the training of predoctoral students in Virology. All of the participating preceptors have trained and graduated at least 1 Ph.D. student and all have current federal grant support for their research programs. Several of the preceptors are accomplished leaders in their research areas, while others are rising stars. The overarching research theme of the training program is virus-host cell interactions, which encompasses 1) mechanisms of viral replication and restriction and 2) molecular pathogenesis. Predoctoral students who seek training in Virology enroll in the Microbiology, Immunology and Cancer Biology (MlCaB) Graduate Program or the Molecular, Cellular and Structural Biology (MCSB) Graduate Program. Students will take graduate level courses in cell and molecular biology and obtain rigorous and intensive coursework in Virology. Predoctoral students will be chosen for this training program from a pool of MICaB and MCSB students, typically in their second or third year of training, by a competitive selection process. Students will be supported for up to 3 years. Students supported by the training program will participate in IMV research-in-progress meetings, IMV subgroup meetings, a virology journal club, an IMV lecture series, and the annual IMV Symposium. Trainees are expected to complete their dissertation research in 4-5 years, publish their work in high-profile virology journals, and pursue postdoctoral training at leading research institutions.

Public Health Relevance

This training program is relevant to public health as it supports career development of young scientists who will help develop new antiviral drugs and vaccines for viral diseases.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Microbiology and Infectious Diseases Research Committee (MID)
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Robbins, Christiane M
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University of Minnesota Twin Cities
Schools of Dentistry/Oral Hygn
United States
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Rawson, Jonathan M O; Clouser, Christine L; Mansky, Louis M (2016) Rapid Determination of HIV-1 Mutant Frequencies and Mutation Spectra Using an mCherry/EGFP Dual-Reporter Viral Vector. Methods Mol Biol 1354:71-88
Maldonado, José O; Cao, Sheng; Zhang, Wei et al. (2016) Distinct Morphology of Human T-Cell Leukemia Virus Type 1-Like Particles. Viruses 8:
Martin, Jessica L; Maldonado, José O; Mueller, Joachim D et al. (2016) Molecular Studies of HTLV-1 Replication: An Update. Viruses 8:
Martin, Jessica L; Cao, Sheng; Maldonado, Jose O et al. (2016) Distinct Particle Morphologies Revealed through Comparative Parallel Analyses of Retrovirus-Like Particles. J Virol 90:8074-84
Rawson, Jonathan M O; Daly, Michele B; Xie, Jiashu et al. (2016) 5-Azacytidine Enhances the Mutagenesis of HIV-1 by Reduction to 5-Aza-2'-Deoxycytidine. Antimicrob Agents Chemother 60:2318-25
Guo, Xi; Schwartz, John C; Murtaugh, Michael P (2016) Genomic variation in the porcine immunoglobulin lambda variable region. Immunogenetics 68:285-93
Cao, Sheng; Maldonado, José O; Grigsby, Iwen F et al. (2015) Analysis of human T-cell leukemia virus type 1 particles by using cryo-electron tomography. J Virol 89:2430-5
Anderson, Brett D; Harris, Reuben S (2015) Transcriptional regulation of APOBEC3 antiviral immunity through the CBF-β/RUNX axis. Sci Adv 1:e1500296
Smith, Elizabeth M; Hennen, Jared; Chen, Yan et al. (2015) In situ quantification of protein binding to the plasma membrane. Biophys J 108:2648-57
Chiu, Amy P; Tschida, Barbara R; Lo, Lilian H et al. (2015) Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma. World J Gastroenterol 21:12157-70

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