The goal of the Viral Pathogenesis Training Program Is to bring together, under one training program, laboratories at the Fred Hutchinson Cancer Research Center (FHCRC), University of Washington (UW) and the Seattle Biomedical Research Institute (SBRI) to form a unique training opportunity for graduate students pursuing research in viral pathogenesis. Each of these Institutions has a rich history of research in viral pathogenesis, but there are no training programs that are focused specifically on research of viral diseases in the Seattle area. Rather, students interested in viral pathogenesis research can enter one of a variety of UW/FHCRC graduate programs that include virology as one of several focus areas. Trainees for the proposed program will be drawn from the existing graduate programs, and will include all of those who chose to pursue research in viral pathogenesis in the laboratories of faculty who are members of this training program. The training faculty study a variety of relevant research topics including: HIV and other retroviruses, human papillomavirus, HCV, Influenza, and herpesviruses such as CMV and HHV-8. The diversity in the viruses studied among participating labs will add breadth to the program, while maintaining an overarching focus on virus-induced diseases among all the participating labs. This common focus will create an umbrella for the students of this training grant that is distinct from existing departmental or program structures. Features of this training program will include common didactic training as well as opportunities for presentations and other interactions among students and faculty.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI083203-04
Application #
8268416
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
2009-08-10
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
4
Fiscal Year
2012
Total Cost
$138,231
Indirect Cost
$8,650
Name
University of Washington
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Xue, Katherine S; Moncla, Louise H; Bedford, Trevor et al. (2018) Within-Host Evolution of Human Influenza Virus. Trends Microbiol 26:781-793
Garcia, Erin I; Emerman, Michael (2018) Recurrent Loss of APOBEC3H Activity during Primate Evolution. J Virol :
Singh, Abhimanyu K; Nguyen, Thanh H; Vidovszky, Márton Z et al. (2018) Structure and N-acetylglucosamine binding of the distal domain of mouse adenovirus 2 fibre. J Gen Virol 99:1494-1508
Hilton, Sarah K; Bloom, Jesse D (2018) Modeling site-specific amino-acid preferences deepens phylogenetic estimates of viral sequence divergence. Virus Evol 4:vey033
Doud, Michael B; Lee, Juhye M; Bloom, Jesse D (2018) How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin. Nat Commun 9:1386
Wilson, Sarah S; Bromme, Beth A; Holly, Mayumi K et al. (2017) Alpha-defensin-dependent enhancement of enteric viral infection. PLoS Pathog 13:e1006446
Hilton, Sarah K; Doud, Michael B; Bloom, Jesse D (2017) phydms: software for phylogenetic analyses informed by deep mutational scanning. PeerJ 5:e3657
Ashenberg, Orr; Padmakumar, Jai; Doud, Michael B et al. (2017) Deep mutational scanning identifies sites in influenza nucleoprotein that affect viral inhibition by MxA. PLoS Pathog 13:e1006288
Doud, Michael B; Hensley, Scott E; Bloom, Jesse D (2017) Complete mapping of viral escape from neutralizing antibodies. PLoS Pathog 13:e1006271
Levan, Justine; Vliet-Gregg, Portia A; Robinson, Kristin L et al. (2017) Human papillomavirus type 16 E6 and NFX1-123 mislocalize immune signaling proteins and downregulate immune gene expression in keratinocytes. PLoS One 12:e0187514

Showing the most recent 10 out of 42 publications