The Viral Pathogenesis Training Program was created to provide an umbrella program for trainees pursuing research in viral pathogenesis in laboratories at the Fred Hutchinson Cancer Research Center (FHCRC) and University of Washington (UW). This training program is designed to enhance opportunities for the top viral pathogenesis students in the Seattle area beyond those provided by their specific graduate program. The UW and FHCRC have a rich history of research in viral pathogenesis, including the study of a diverse array of viral globally relevant pathogens such as HIV, Influenza and oncogenic (HCV, KHSV, HPV, MCPyV) and opportunistic (HSV, CMV, AdV) pathogens. However, predoctoral students pursing studies of viral pathogenesis are dispersed among a variety of graduate programs and laboratories at UW and FHCRC. This program will support trainees who are studying viral pathogens at both FHCRC and UW. Eligible trainees will include all of those who chose to pursue research in viral pathogenesis in the laboratories of faculty who are members of this training program. Thus, trainees for the proposed program will be drawn from several existing graduate programs that have training in virology as one are of emphasis. Features of this training program will include common didactic training as well as opportunities for presentations and other interactions among students and faculty. The diversity in the viruses studied among participating labs will add breadth to the program, while maintaining an overarching focus on virus-induced diseases among all the participating labs. This common focus will create an umbrella for the students of this training grant that is distinct from existin departmental or program structures. The Viral Pathogenesis Training Grant is the only training grant in Seattle that is focused on virus research in general or viral pathogenesis in particular.
Viral diseases are a major contributing factors in the morbidity and mortality associated with infectious diseases in the world. Several viruses, both new and old, threaten to become emerging pathogens of global relevance. Training future scientist who can help combat the devastation of viral diseases is critical for global health.
|Doud, Michael B; Hensley, Scott E; Bloom, Jesse D (2017) Complete mapping of viral escape from neutralizing antibodies. PLoS Pathog 13:e1006271|
|Hilton, Sarah K; Doud, Michael B; Bloom, Jesse D (2017) phydms: software for phylogenetic analyses informed by deep mutational scanning. PeerJ 5:e3657|
|Levan, Justine; Vliet-Gregg, Portia A; Robinson, Kristin L et al. (2017) Human papillomavirus type 16 E6 and NFX1-123 mislocalize immune signaling proteins and downregulate immune gene expression in keratinocytes. PLoS One 12:e0187514|
|Wilson, Sarah S; Bromme, Beth A; Holly, Mayumi K et al. (2017) Alpha-defensin-dependent enhancement of enteric viral infection. PLoS Pathog 13:e1006446|
|Ashenberg, Orr; Padmakumar, Jai; Doud, Michael B et al. (2017) Deep mutational scanning identifies sites in influenza nucleoprotein that affect viral inhibition by MxA. PLoS Pathog 13:e1006288|
|Milligan, Caitlin; Omenda, Maxwel M; Chohan, Vrasha et al. (2016) Maternal Neutralization-Resistant Virus Variants Do Not Predict Infant HIV Infection Risk. MBio 7:e02221-15|
|Simonich, Cassandra A; Williams, Katherine L; Verkerke, Hans P et al. (2016) HIV-1 Neutralizing Antibodies with Limited Hypermutation from an Infant. Cell 166:77-87|
|Gounder, Anshu P; Myers, Nicolle D; Treuting, Piper M et al. (2016) Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection. PLoS Pathog 12:e1005474|
|Soerens, A G; Da Costa, A; Lund, J M (2016) Regulatory T cells are essential to promote proper CD4 T-cell priming upon mucosal infection. Mucosal Immunol 9:1395-1406|
|Pattabhi, Sowmya; Wilkins, Courtney R; Dong, Ran et al. (2016) Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway. J Virol 90:2372-87|
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