The Viral Pathogenesis Training Program was created to provide an umbrella program for trainees pursuing research in viral pathogenesis in laboratories at the Fred Hutchinson Cancer Research Center (FHCRC) and University of Washington (UW). This training program is designed to enhance opportunities for the top viral pathogenesis students in the Seattle area beyond those provided by their specific graduate program. The UW and FHCRC have a rich history of research in viral pathogenesis, including the study of a diverse array of viral globally relevant pathogens such as HIV, Influenza and oncogenic (HCV, KHSV, HPV, MCPyV) and opportunistic (HSV, CMV, AdV) pathogens. However, predoctoral students pursing studies of viral pathogenesis are dispersed among a variety of graduate programs and laboratories at UW and FHCRC. This program will support trainees who are studying viral pathogens at both FHCRC and UW. Eligible trainees will include all of those who chose to pursue research in viral pathogenesis in the laboratories of faculty who are members of this training program. Thus, trainees for the proposed program will be drawn from several existing graduate programs that have training in virology as one are of emphasis. Features of this training program will include common didactic training as well as opportunities for presentations and other interactions among students and faculty. The diversity in the viruses studied among participating labs will add breadth to the program, while maintaining an overarching focus on virus-induced diseases among all the participating labs. This common focus will create an umbrella for the students of this training grant that is distinct from existin departmental or program structures. The Viral Pathogenesis Training Grant is the only training grant in Seattle that is focused on virus research in general or viral pathogenesis in particular.

Public Health Relevance

Viral diseases are a major contributing factors in the morbidity and mortality associated with infectious diseases in the world. Several viruses, both new and old, threaten to become emerging pathogens of global relevance. Training future scientist who can help combat the devastation of viral diseases is critical for global health.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
Schools of Medicine
United States
Zip Code
Wilson, S S; Tocchi, A; Holly, M K et al. (2015) A small intestinal organoid model of non-invasive enteric pathogen-epithelial cell interactions. Mucosal Immunol 8:352-61
Kell, Alison M; Wargo, Andrew R; Kurath, Gael (2014) Viral fitness does not correlate with three genotype displacement events involving infectious hematopoietic necrosis virus. Virology 464-465:146-55
Gasper, Melanie A; Kunwar, Pratima; Itaya, Grace et al. (2014) Natural killer cell and T-cell subset distributions and activation influence susceptibility to perinatal HIV-1 infection. AIDS 28:1115-24
Omenda, Maxwel M; Milligan, Caitlin; Odem-Davis, Katherine et al. (2013) Evidence for efficient vertical transfer of maternal HIV-1 envelope-specific neutralizing antibodies but no association of such antibodies with reduced infant infection. J Acquir Immune Defic Syndr 64:163-6
Compton, Alex A; Emerman, Michael (2013) Convergence and divergence in the evolution of the APOBEC3G-Vif interaction reveal ancient origins of simian immunodeficiency viruses. PLoS Pathog 9:e1003135
Wilson, Sarah S; Wiens, Mayim E; Smith, Jason G (2013) Antiviral mechanisms of human defensins. J Mol Biol 425:4965-80
Mir, Kiran D; Bosinger, Steven E; Gasper, Melanie et al. (2012) Simian immunodeficiency virus-induced alterations in monocyte production of tumor necrosis factor alpha contribute to reduced immune activation in sooty mangabeys. J Virol 86:7605-15
Compton, Alex A; Hirsch, Vanessa M; Emerman, Michael (2012) The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict. Cell Host Microbe 11:91-8
Cortez, Valerie; Odem-Davis, Katherine; McClelland, R Scott et al. (2012) HIV-1 superinfection in women broadens and strengthens the neutralizing antibody response. PLoS Pathog 8:e1002611
Provine, Nicholas M; Cortez, Valerie; Chohan, Vrasha et al. (2012) The neutralization sensitivity of viruses representing human immunodeficiency virus type 1 variants of diverse subtypes from early in infection is dependent on producer cell, as well as characteristics of the specific antibody and envelope variant. Virology 427:25-33