The Viral Pathogenesis Training Program was created to provide an umbrella program for trainees pursuing research in viral pathogenesis in laboratories at the Fred Hutchinson Cancer Research Center (FHCRC) and University of Washington (UW). This training program is designed to enhance opportunities for the top viral pathogenesis students in the Seattle area beyond those provided by their specific graduate program. The UW and FHCRC have a rich history of research in viral pathogenesis, including the study of a diverse array of viral globally relevant pathogens such as HIV, Influenza and oncogenic (HCV, KHSV, HPV, MCPyV) and opportunistic (HSV, CMV, AdV) pathogens. However, predoctoral students pursing studies of viral pathogenesis are dispersed among a variety of graduate programs and laboratories at UW and FHCRC. This program will support trainees who are studying viral pathogens at both FHCRC and UW. Eligible trainees will include all of those who chose to pursue research in viral pathogenesis in the laboratories of faculty who are members of this training program. Thus, trainees for the proposed program will be drawn from several existing graduate programs that have training in virology as one are of emphasis. Features of this training program will include common didactic training as well as opportunities for presentations and other interactions among students and faculty. The diversity in the viruses studied among participating labs will add breadth to the program, while maintaining an overarching focus on virus-induced diseases among all the participating labs. This common focus will create an umbrella for the students of this training grant that is distinct from existin departmental or program structures. The Viral Pathogenesis Training Grant is the only training grant in Seattle that is focused on virus research in general or viral pathogenesis in particular.

Public Health Relevance

Viral diseases are a major contributing factors in the morbidity and mortality associated with infectious diseases in the world. Several viruses, both new and old, threaten to become emerging pathogens of global relevance. Training future scientist who can help combat the devastation of viral diseases is critical for global health.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
Schools of Medicine
United States
Zip Code
Pattabhi, Sowmya; Wilkins, Courtney R; Dong, Ran et al. (2016) Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway. J Virol 90:2372-87
Gounder, Anshu P; Myers, Nicolle D; Treuting, Piper M et al. (2016) Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection. PLoS Pathog 12:e1005474
Zolla-Pazner, Susan; Cohen, Sandra Sharpe; Boyd, David et al. (2016) Structure/Function Studies Involving the V3 Region of the HIV-1 Envelope Delineate Multiple Factors That Affect Neutralization Sensitivity. J Virol 90:636-49
Simonich, Cassandra A; Williams, Katherine L; Verkerke, Hans P et al. (2016) HIV-1 Neutralizing Antibodies with Limited Hypermutation from an Infant. Cell 166:77-87
Soerens, A G; Da Costa, A; Lund, J M (2016) Regulatory T cells are essential to promote proper CD4 T-cell priming upon mucosal infection. Mucosal Immunol :
Milligan, Caitlin; Omenda, Maxwel M; Chohan, Vrasha et al. (2016) Maternal Neutralization-Resistant Virus Variants Do Not Predict Infant HIV Infection Risk. MBio 7:e02221-15
Boyd, David F; Peterson, Dylan; Haggarty, Beth S et al. (2015) Mutations in HIV-1 envelope that enhance entry with the macaque CD4 receptor alter antibody recognition by disrupting quaternary interactions within the trimer. J Virol 89:894-907
Milligan, Caitlin; Richardson, Barbra A; John-Stewart, Grace et al. (2015) FCGR2A and FCGR3A Genotypes in Human Immunodeficiency Virus Mother-to-Child Transmission. Open Forum Infect Dis 2:ofv149
Doud, Michael B; Ashenberg, Orr; Bloom, Jesse D (2015) Site-Specific Amino Acid Preferences Are Mostly Conserved in Two Closely Related Protein Homologs. Mol Biol Evol 32:2944-60
Wilson, S S; Tocchi, A; Holly, M K et al. (2015) A small intestinal organoid model of non-invasive enteric pathogen-epithelial cell interactions. Mucosal Immunol 8:352-61

Showing the most recent 10 out of 31 publications