We are seeking support to train graduate students over a five year period in the area of host-pathogen interactions. Seventeen investigators in 5 colleges at the University of Maryland whose primary research interest pertains to host-pathogen interactions have come together to form a research cluster in the newly- formed BISI graduate program in the College of Chemical and Life Sciences. The devastating effects of infectious diseases caused by pathogens such as tuberculosis, meningitis, leishmaniasis, influenza and other parasitic infections, etc. are well known, and efforts to understand the mechanisms of microbial pathogenesis are easily justified from a world health perspective. The importance of microbial pathogens extends well beyond the diseases they cause, because studying their pathogenesis will lead to new insights in immunology and cellular biology. Thus, this is an excellent area for graduate student training. This training proposal seeks support for a unique training program that will immerse students in interdisciplinary research, striving to integrate advances in genomics, immunology, and microbial pathogenesis with our rapidly expanding understanding of host-pathogen interactions. The goal of this program is to train graduate students in basic cell and molecular biology of host-pathogen interactions, with an eye to developing translational approaches to improve health.

Public Health Relevance

Pathogens infect nearly all life forms and many have the potential to cause world-wide pandemics. This training proposal seeks support to train predoctoral students to meet the research challenges that these diseases are likely to create. The diverse faculty will bring a variety of expertise to bear on problems that are common to studying host-pathogen interactions. This program includes developing strategies to protect humans and animals to improve the quality of people's lives.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
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University of Maryland College Park
Anatomy/Cell Biology
Schools of Earth Sciences/Natur
College Park
United States
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Le Breton, Yoann; Belew, Ashton T; Freiberg, Jeffrey A et al. (2017) Genome-wide discovery of novel M1T1 group A streptococcal determinants important for fitness and virulence during soft-tissue infection. PLoS Pathog 13:e1006584
Zhang, Peipei; Andorko, James I; Jewell, Christopher M (2017) Impact of dose, route, and composition on the immunogenicity of immune polyelectrolyte multilayers delivered on gold templates. Biotechnol Bioeng 114:423-431
Hess, Krystina L; Andorko, James I; Tostanoski, Lisa H et al. (2017) Polyplexes assembled from self-peptides and regulatory nucleic acids blunt toll-like receptor signaling to combat autoimmunity. Biomaterials 118:51-62
Ory, Eleanor C; Chen, Desu; Chakrabarti, Kristi R et al. (2017) Extracting microtentacle dynamics of tumor cells in a non-adherent environment. Oncotarget 8:111567-111580
Sundar, Ganesh S; Islam, Emrul; Gera, Kanika et al. (2017) A PTS EII mutant library in Group A Streptococcus identifies a promiscuous man-family PTS transporter influencing SLS-mediated hemolysis. Mol Microbiol 103:518-533
Christensen, Stephen M; Dillon, Laura A L; Carvalho, Lucas P et al. (2016) Meta-transcriptome Profiling of the Human-Leishmania braziliensis Cutaneous Lesion. PLoS Negl Trop Dis 10:e0004992
Chiu, Yu-Chieh; Gammon, Joshua M; Andorko, James I et al. (2016) Assembly and Immunological Processing of Polyelectrolyte Multilayers Composed of Antigens and Adjuvants. ACS Appl Mater Interfaces 8:18722-31
Andorko, James I; Hess, Krystina L; Pineault, Kevin G et al. (2016) Intrinsic immunogenicity of rapidly-degradable polymers evolves during degradation. Acta Biomater 32:24-34
Moghaddam-Taaheri, Parisa; Ikonomova, Svetlana P; Gong, Zifan et al. (2016) Bacterial Inner-membrane Display for Screening a Library of Antibody Fragments. J Vis Exp :
Tostanoski, Lisa H; Chiu, Yu-Chieh; Gammon, Joshua M et al. (2016) Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific. Cell Rep 16:2940-2952

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