The Harvard Medical School Department of Dermatology training grant (now administered by Brigham and Women's Hospital) has a long and distinguished history of preparing individuals for careers in biomedical research relevant to the skin. Historically, one of its major roles has been to support the development of dermatologist physician scientists interested in a career in biomedical research. It also supports the development of PhD scientists who are seeking a biomedical research career relevant to skin biology, skin diseases, and skin cancers. During the last funding cycle, the training grant has achieved its goals, training both dermatologist physician scientists and PhD scientists, the vast majority of whom are employed at academic institutions or in the biotechnology sector. Looking back over a longer timeline, we are able to demonstrate that trainees on our training grant have generated over 120 publications in peer reviewed journals, including some of the highest impact journals in the biomedical sciences. In addition, ex-trainees have been funded by RO1 grants, K awards, other NIH grants, and multiple awards from the Dermatology Foundation and other private funding agencies. Since 2008, the Harvard Medical School Department of Dermatology has been decentralized into three affiliated Harvard Departments based at the key affiliated hospital-the Beth Israel Deaconess Medical Center, the Brigham and Women's Hospital, and the Massachusetts General Hospitals. The Chairs of these hospitals are represented on an Executive Committee, currently chaired by Dr. Kupper. Given this decentralization, the Harvard Dermatology training grant assumes an even greater significance as the """"""""glue"""""""" that helps hold these departments together, along with the shared residency program. The training grant goals over the next five years are unchanged: to identify, support, and train the best and most promising dermatologist physician scientists, and PhD (non-MD) scientists, as a means of preparing them for careers in biomedical research. It appears that pay line percentiles in most NIH institutes will remain in the low-teens for the foreseeable future. This means, quite simply, that training grant support for young biomedical scientists interested in skin disease research has never been more critical to the success of their careers, and by extension, to the survival of our specialty.

Public Health Relevance

At least two years of mentorship and training in research approaches and techniques are absolutely essential as graduates of dermatology training programs or PhD programs transition from student to independent biomedical scientists. The Harvard Dermatology Training grant provides this support, partnering the most promising trainees with accomplished and supportive research mentors who will sponsor their work in their laboratories. We wish to continue to build on the extraordinary success that this program has achieved over the last 35 years, in training the best and the brightest biomedical scientists of tomorrow.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Institutional National Research Service Award (T32)
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Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
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Cibotti, Ricardo
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Brigham and Women's Hospital
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Paul, Suchismita; Evans, Rachel; Maurer, Toby et al. (2016) Treatment of Dermatological Conditions Associated with HIV/AIDS: The Scarcity of Guidance on a Global Scale. AIDS Res Treat 2016:3272483
Freeman, Esther; Semeere, Aggrey; Wenger, Megan et al. (2015) Pitfalls of practicing cancer epidemiology in resource-limited settings: the case of survival and loss to follow-up after a diagnosis of Kaposi's sarcoma in five countries across sub-Saharan Africa. BMC Cancer 16:65
Garibyan, Lilit; Cornelissen, Laura; Sipprell, William et al. (2015) Transient Alterations of Cutaneous Sensory Nerve Function by Noninvasive Cryolipolysis. J Invest Dermatol 135:2623-31
Miao, Benchun; Ji, Zhenyu; Tan, Li et al. (2015) EPHA2 is a mediator of vemurafenib resistance and a novel therapeutic target in melanoma. Cancer Discov 5:274-87
Friedman, Adam A; Amzallag, Arnaud; Pruteanu-Malinici, Iulian et al. (2015) Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment. PLoS One 10:e0140310
Kirsch, Ilan R; Watanabe, Rei; O'Malley, John T et al. (2015) TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL. Sci Transl Med 7:308ra158
Ji, Zhenyu; Erin Chen, Yiyin; Kumar, Raj et al. (2015) MITF Modulates Therapeutic Resistance through EGFR Signaling. J Invest Dermatol 135:1863-72
Mollah, Shamim A; Dobrin, Joseph S; Feder, Rachel E et al. (2014) Flt3L dependence helps define an uncharacterized subset of murine cutaneous dendritic cells. J Invest Dermatol 134:1265-75
Larson, Allison R; Lee, Chung-Wei; Lezcano, Cecilia et al. (2014) Melanoma spheroid formation involves laminin-associated vasculogenic mimicry. Am J Pathol 184:71-8
Lee, Chung-Wei; Zhan, Qian; Lezcano, Cecilia et al. (2014) Nestin depletion induces melanoma matrix metalloproteinases and invasion. Lab Invest 94:1382-95

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