The Harvard Medical School Department of Dermatology training grant (now administered by Brigham and Women's Hospital) has a long and distinguished history of preparing individuals for careers in biomedical research relevant to the skin. Historically, one of its major roles has been to support the development of dermatologist physician scientists interested in a career in biomedical research. It also supports the development of PhD scientists who are seeking a biomedical research career relevant to skin biology, skin diseases, and skin cancers. During the last funding cycle, the training grant has achieved its goals, training both dermatologist physician scientists and PhD scientists, the vast majority of whom are employed at academic institutions or in the biotechnology sector. Looking back over a longer timeline, we are able to demonstrate that trainees on our training grant have generated over 120 publications in peer reviewed journals, including some of the highest impact journals in the biomedical sciences. In addition, ex-trainees have been funded by RO1 grants, K awards, other NIH grants, and multiple awards from the Dermatology Foundation and other private funding agencies. Since 2008, the Harvard Medical School Department of Dermatology has been decentralized into three affiliated Harvard Departments based at the key affiliated hospital-the Beth Israel Deaconess Medical Center, the Brigham and Women's Hospital, and the Massachusetts General Hospitals. The Chairs of these hospitals are represented on an Executive Committee, currently chaired by Dr. Kupper. Given this decentralization, the Harvard Dermatology training grant assumes an even greater significance as the """"""""glue"""""""" that helps hold these departments together, along with the shared residency program. The training grant goals over the next five years are unchanged: to identify, support, and train the best and most promising dermatologist physician scientists, and PhD (non-MD) scientists, as a means of preparing them for careers in biomedical research. It appears that pay line percentiles in most NIH institutes will remain in the low-teens for the foreseeable future. This means, quite simply, that training grant support for young biomedical scientists interested in skin disease research has never been more critical to the success of their careers, and by extension, to the survival of our specialty.
At least two years of mentorship and training in research approaches and techniques are absolutely essential as graduates of dermatology training programs or PhD programs transition from student to independent biomedical scientists. The Harvard Dermatology Training grant provides this support, partnering the most promising trainees with accomplished and supportive research mentors who will sponsor their work in their laboratories. We wish to continue to build on the extraordinary success that this program has achieved over the last 35 years, in training the best and the brightest biomedical scientists of tomorrow.
|Nirschl, Christopher J; Suárez-Fariñas, Mayte; Izar, Benjamin et al. (2017) IFN?-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment. Cell 170:127-141.e15|
|Hayakawa, Morisada; Hayakawa, Hiroko; Petrova, Tsvetana et al. (2017) Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction. J Biol Chem 292:1762-1772|
|Semeere, Aggrey; Freeman, Esther; Wenger, Megan et al. (2017) Updating vital status by tracking in the community among patients with epidemic Kaposi sarcoma who are lost to follow-up in sub-Saharan Africa. BMC Cancer 17:611|
|Freeman, Esther; Semeere, Aggrey; Wenger, Megan et al. (2016) Pitfalls of practicing cancer epidemiology in resource-limited settings: the case of survival and loss to follow-up after a diagnosis of Kaposi's sarcoma in five countries across sub-Saharan Africa. BMC Cancer 16:65|
|Vieyra-Garcia, Pablo A; Wei, Tianling; Naym, David Gram et al. (2016) STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides. Clin Cancer Res 22:3328-39|
|Borges, T J; O'Malley, J T; Wo, L et al. (2016) Codominant Role of Interferon-?- and Interleukin-17-Producing T Cells During Rejection in Full Facial Transplant Recipients. Am J Transplant 16:2158-71|
|Zhuang, Quan; Liu, Quan; Divito, Sherrie J et al. (2016) Graft-infiltrating host dendritic cells play a key role in organ transplant rejection. Nat Commun 7:12623|
|Paul, Suchismita; Evans, Rachel; Maurer, Toby et al. (2016) Treatment of Dermatological Conditions Associated with HIV/AIDS: The Scarcity of Guidance on a Global Scale. AIDS Res Treat 2016:3272483|
|Liu, Quan; Rojas-Canales, Darling M; Divito, Sherrie J et al. (2016) Donor dendritic cell-derived exosomes promote allograft-targeting immune response. J Clin Invest 126:2805-20|
|Becattini, Barbara; Zani, Fabio; Breasson, Ludovic et al. (2016) JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage. FASEB J 30:3124-32|
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