The NIH-sponsored Training Program in Investigative Rheumatology, begun at Yale in 1976, has the philosophy that a portion of both M.D. and Ph.D. biomedical scientists should be trained in an environment that focuses upon mechanisms of rheumatologic and immunologic diseases, and approaches to the bedside investigation of these illnesses. This belief is grounded in the notion that the challenges involved in understanding such clinical problems require a cohort of investigators whose knowledge and training enable them to span the gaps between basic biology and clinical rheumatology and immunology. Hence, the goals of this program are to attract individuals who are interested in learning about fundamental mechanisms of disease and the applications of this knowledge. The program is focused upon clinical investigation in the rheumatic diseases, with an emphasis on providing training in immunology, microbiology, cellular and molecular biology, and the clinical sciences as applied to the understanding and therapy of rheumatic diseases;is comprised of both physician and Ph.D. trainees;and has for its training faculty a collaborative group of 36 physician and basic scientists from the Section of Rheumatology and other Sections in the Department of Medicine, and basic investigators from the Department of Immunobiology. The quality, cohesiveness, and diverse skills of these mentors, along with the skills and the desire of our trainees, are the most important requisites for success of our program. Five trainees (M.D. and Ph.D.) per year are currently supported, with an increase to six requested in this renewal. This request is based upon the continued success of the program and the number of high quality applicants and mentors. M.D. trainees typically perform clinical work in the first year of their fellowship (supported by clinical funds), and then enter research training. The combination of both M.D. and Ph.D. fellows gives the M.D. fellows a much better research experience, and it exposes the Ph.D. fellows to opportunities to apply their skills to rheumatologic problems. Fellows supported by this Training Grant receive didactic as well as interactive instruction in biology, clinical investigation, and ethical issues in science. This program provides trainees with the foundation in basic and clinical science that will enable them to bridge the differences between basic research and clinical approaches to understanding rheumatic diseases.

Public Health Relevance

The understanding and treatment of the rheumatic diseases requires a cadre of highly trained physician and Ph.D. scientists. The goals of this program are to train the next generation of such individuals, by seeking highly qualified trainees, and providing them with intense exposure to other highly qualified trainees with a wide range of backgrounds and offering them mentorship from a high quality and broad-based training faculty. This philosophy has been highly successful in producing investigators devoted to dissecting the mechanisms of rheumatologic and immunologic diseases, and approaches to the bedside investigation of these illnesses, and it is anticipated that it will remain so with the training plan and mentorship that is provided by this training program.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZAR1-CHW (M4))
Program Officer
Mancini, Marie
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Yale University
Internal Medicine/Medicine
Schools of Medicine
New Haven
United States
Zip Code
Weinstein, Jason S; Bertino, Sarah A; Hernandez, Sairy G et al. (2014) B cells in T follicular helper cell development and function: separable roles in delivery of ICOS ligand and antigen. J Immunol 192:3166-79
Palm, Noah W; de Zoete, Marcel R; Cullen, Thomas W et al. (2014) Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell 158:1000-10
Shin, Min Sun; Kang, Youna; Lee, Naeun et al. (2013) Self double-stranded (ds)DNA induces IL-1* production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies. J Immunol 190:1407-15
Das, Rituparna; Moss, Jeremy E; Robinson, Eve et al. (2011) Role of macrophage migration inhibitory factor in the Th2 immune response to epicutaneous sensitization. J Clin Immunol 31:666-80
Harding, Martha J; Lepus, Christin M; Gibson, Thomas F et al. (2010) An implantable vascularized protein gel construct that supports human fetal hepatoblast survival and infection by hepatitis C virus in mice. PLoS One 5:e9987
Gerber, Scott A; Yatsula, Bogdan; Maier, Cheryl L et al. (2009) Interferon-gamma induces prolyl hydroxylase (PHD)3 through a STAT1-dependent mechanism in human endothelial cells. Arterioscler Thromb Vasc Biol 29:1363-9
Vesely, Diana L; Fish, Durland; Shlomchik, Mark J et al. (2009) Langerhans cell deficiency impairs Ixodes scapularis suppression of Th1 responses in mice. Infect Immun 77:1881-7
Gerber, Scott A; Pober, Jordan S (2008) IFN-alpha induces transcription of hypoxia-inducible factor-1alpha to inhibit proliferation of human endothelial cells. J Immunol 181:1052-62
Montgomery, Ruth R; Lusitani, Denise; De Boisfleury Chevance, Anne et al. (2004) Tick saliva reduces adherence and area of human neutrophils. Infect Immun 72:2989-94
Lusitani, Denise; Malawista, Stephen E; Montgomery, Ruth R (2003) Calprotectin, an abundant cytosolic protein from human polymorphonuclear leukocytes, inhibits the growth of Borrelia burgdorferi. Infect Immun 71:4711-6

Showing the most recent 10 out of 33 publications