The Dermatology Department at the University of California, San Francisco, has a long tradition of training promising young scientists to be successful, independent investigators. With the expansion to the Mission Bay Campus, UCSF has added >600,000 square feet of new research space and is in the process of recruiting approximately 100 new faculty members. The UCSF Dermatology Department is also expanding in terms of research space, the number of faculty conducting basic and applied research, and the number of residents and fellows. The UCSF Dermatology Training Program encourages physician scientist trainees to pursue cutting edge research in any laboratory in the UC system, and, if it makes sense, in laboratories in other eminent institutions in the San Francisco Bay Area, including Stanford University and UC-Berkeley. This allows trainees to choose from all outstanding faculty members at UCSF and our neighboring institutions, regardless of their departmental affiliation. Building on our successes in the past and capitalizing on the UCSF expansion, we propose to continue our training program to groom not only train physician scientists, but also PhD fellows who will become successful researchers in skin biology. The UCSF dermatology training program is designed to prepare physicians and PhD scientists for a lifetime of scholarly pursuit with the ultimate goal of understanding the molecular basis of skin diseases and finding new therapies for these diseases. Our two-fold goals of exposing our physician scientist trainees to the rich scientific research milieu at UCSF and of recruiting PhD scientists to study skin biology in the department will ensure that a cadre of young scientists will pursue academic careers in dermatological research and advance the field in fundamental ways.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR007175-35
Application #
8255336
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Baker, Carl
Project Start
1976-07-01
Project End
2014-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
35
Fiscal Year
2012
Total Cost
$220,369
Indirect Cost
$18,161
Name
University of California San Francisco
Department
Dermatology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Mak, Angel C Y; Pullinger, Clive R; Tang, Ling Fung et al. (2014) Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function. JAMA Neurol 71:1228-36
Gray, Elizabeth E; Ramirez-Valle, Francisco; Xu, Ying et al. (2013) Deficiency in IL-17-committed Výý4(+) ýýýý T cells in a spontaneous Sox13-mutant CD45.1(+) congenic mouse substrain provides protection from dermatitis. Nat Immunol 14:584-92
Strachan, Lauren R; Ghadially, Ruby (2008) Tiers of clonal organization in the epidermis: the epidermal proliferation unit revisited. Stem Cell Rev 4:149-57
Aberg, Karin M; Man, Mao-Qiang; Gallo, Richard L et al. (2008) Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J Invest Dermatol 128:917-25
Aberg, Karin M; Radek, Katherine A; Choi, Eung-Ho et al. (2007) Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J Clin Invest 117:3339-49
Cleaver, J E; Hefner, E; Laposa, R R et al. (2007) Cockayne syndrome exhibits dysregulation of p21 and other gene products that may be independent of transcription-coupled repair. Neuroscience 145:1300-8
Marti, Thomas M; Hefner, Eli; Feeney, Luzviminda et al. (2006) H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks. Proc Natl Acad Sci U S A 103:9891-6
Laposa, Rebecca R; Feeney, Luzviminda; Cleaver, James E (2003) Recapitulation of the cellular xeroderma pigmentosum-variant phenotypes using short interfering RNA for DNA polymerase H. Cancer Res 63:3909-12
Cleaver, James E; Crowley, Eileen (2002) UV damage, DNA repair and skin carcinogenesis. Front Biosci 7:d1024-43
Mohle-Boetani, J C; Koehler, J E; Berger, T G et al. (1996) Bacillary angiomatosis and bacillary peliosis in patients infected with human immunodeficiency virus: clinical characteristics in a case-control study. Clin Infect Dis 22:794-800

Showing the most recent 10 out of 15 publications