(taken from application) This program is designed for research training in the biology of the extracellular matrix and the pathobiology of rheumatic and skeletal diseases.
Our aims are to have trainees gain experience in the cell and molecular biology, developmental biology and biochemistry that underlies connective tissue remodeling under physiological conditions and degradation and synthesis under pathological conditions. Individual supervised research and course work are principal components. Areas that are emphasized in this program include studies of inflammatory mechanisms and the cellular interactions involved, synthesis and degradation of components of the extracellular matrix, the role of ligands such as hormones and cytokines that influence these cellular interactions, the role of the receptors for these ligands and aspects of the cellular events concerned such as chemotaxis. The use of animal models forms an important basis for this training in addition to studies of cells and tissue fragments from patients with these disorders Another aspect of this training program includes clinical investigations such as clinical trials of new agents, the evaluation of biological and structural markers as surrogates for clinical endpoints and the use of regression modeling and clinical epidemiological studies to evaluate the utility of prognostic factor in several large databases. The faculty of this program have their laboratories either at the MGH main campus, the large laboratory facility at MGH-East in Charlestown and other laboratories located within the Harvard Medical School complex including the Center for Blood Research and the laboratories of the New England Baptist Bone and Joint Institute located at the Harvard Institutes of Medicine. Most of the trainees in this program are postdoctoral and include individuals with M.D./Ph.D. or dental degrees (D.D.S. or D.M.D.) Also included are undergraduate medical students who spend periods of several months to a year or, more in these laboratories and other undergraduate students who are usually here for shorter periods, such as students working towards an Honors thesis at Harvard College. There are, in addition, students from the Harvard School of Dental Medicine who already have their graduate dental degrees but are working toward Master's or Doctorate degrees in dental science.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR007258-23
Application #
6171797
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Ader, Deborah N
Project Start
1977-07-01
Project End
2003-04-30
Budget Start
2000-05-01
Budget End
2001-04-30
Support Year
23
Fiscal Year
2000
Total Cost
$78,259
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Jorge, April M; Lu, Na; Keller, Sarah F et al. (2018) The Effect of Statin Use on Mortality in Systemic Autoimmune Rheumatic Diseases. J Rheumatol 45:1689-1695
Sorensen, Elizabeth W; Lian, Jeffrey; Ozga, Aleksandra J et al. (2018) CXCL10 stabilizes T cell-brain endothelial cell adhesion leading to the induction of cerebral malaria. JCI Insight 3:
Jorge, April; Wallace, Zachary S; Zhang, Yuqing et al. (2018) All-Cause and Cause-Specific Mortality Trends of End-Stage Renal Disease due to Lupus Nephritis from 1995 to 2014. Arthritis Rheumatol :
Jorge, April M; Melles, Ronald B; Zhang, Yuqing et al. (2018) Hydroxychloroquine prescription trends and predictors for excess dosing per recent ophthalmology guidelines. Arthritis Res Ther 20:133
Perugino, Cory A; AlSalem, Sultan B; Mattoo, Hamid et al. (2018) Identification of galectin-3 as an autoantigen in patients with IgG4-related disease. J Allergy Clin Immunol :
Wallace, Zachary S; Zhang, Yuqing; Lu, Na et al. (2018) Improving Mortality in End-Stage Renal Disease Due to Granulomatosis With Polyangiitis (Wegener's) From 1995 to 2014: Data From the United States Renal Data System. Arthritis Care Res (Hoboken) 70:1495-1500
Lochhead, Robert B; OrdoƱez, David; Arvikar, Sheila L et al. (2018) Interferon-gamma production in Lyme arthritis synovial tissue promotes differentiation of fibroblast-like synoviocytes into immune effector cells. Cell Microbiol :e12992
Sulka, Katherine B; Strle, Klemen; Crowley, Jameson T et al. (2018) Correlation of Lyme Disease-Associated IgG4 Autoantibodies With Synovial Pathology in Antibiotic-Refractory Lyme Arthritis. Arthritis Rheumatol 70:1835-1846
Wallace, Zachary S; Khosroshahi, Arezou; Carruthers, Mollie D et al. (2018) An International Multispecialty Validation Study of the IgG4-Related Disease Responder Index. Arthritis Care Res (Hoboken) 70:1671-1678
Wallace, Zachary S; Lu, Na; Miloslavsky, Eli et al. (2017) Nationwide Trends in Hospitalizations and In-Hospital Mortality in Granulomatosis With Polyangiitis (Wegener's). Arthritis Care Res (Hoboken) 69:915-921

Showing the most recent 10 out of 62 publications