This is the 36th year of this highly successful research training program in Rheumatology at the Massachusetts General Hospital (MGH), Harvard Medical School (HMS), supported by training grant T32 AR07258. The goal of this program is to train MD, MD/PhD and PhD post-doctoral fellows for independent investigative careers in rheumatology research. Of the 54 graduates of the program that were directly supported by this training grant, many now have faculty appointments in academic medical centers, including holding leadership positions at major institutions as Deans, Scientific Directors, and Division Chiefs. Our program centers on our highly successful clinical fellowship in Rheumatology and our strong basic, translational and clinical science programs situated in an exciting, vibrant and technologically innovative research environment. Our Rheumatology Training Program provides supervised laboratory and clinical research under the guidance of accomplished faculty members, as well as structured training in rheumatology, immunology, clinical trials, biostatistics and ethical issues through courses or conferences. The research focus of the program is the study of the immunopathogenesis of rheumatic disease. Areas of particular interest include autoimmunity, innate immunity, leukocyte trafficking, inflammation, infectious causes of rheumatic diseases, systems immunology, fibrosis, and stem cell biology. Disease areas of particular interest include rheumatoid arthritis, lupus, scleroderma, Lyme, vasculitis and IgG4-related disease. This application requests 4 training positions that will be allocated to trainees who are committed to at least 2 to 3 years of research training. The candidates will be drawn from the MGH Rheumatology fellowship and from post-doctoral trainees already in faculty mentor laboratories. Twelve faculty members primarily from the MGH Rheumatology Unit and its affiliated Center for Immunology &Inflammatory Diseases (CIID) participate in this Rheumatology Training Program and were carefully chosen based on their track record of publication, grants, mentoring, collaboration and a mutual interest in rheumatology and immunology. The training program also leverages many of the research centers at MGH, including the Centers Systems Biology, Cancer, Regenerative Medicine, and Cardiovascular Disease. The MGH provides an outstanding training environment with over 1400 investigators, thematic research centers, trainee support groups, and over $700 million in NIH research grant awards. Opportunities at Harvard University, including course work and the Harvard Clinical and Translational Science Center (a member of the NIH-funded Clinical and Translational Science Award Consortium) and the Broad Institute of MIT and Harvard provide additional valuable resources for trainees. In sum, in this renewal application, we have created a cohesive, integrated, high quality training program in basic, translational and clinical research i the pathogenesis and treatment of rheumatic diseases.
Research Training in Rheumatology at the Massachusetts General Hospital is designed to prepare the next generations of research scientists who, through mentored research and rigorous training in new technologies, are prepared to be leaders in rheumatology related biomedical research. The overall goal of this program is to educate trainees so that they can contribute to our understanding of the immunopathogenesis of rheumatic diseases, and translate these findings to better clinical care for patients with these important diseases.
|Marangoni, Francesco; Murooka, Thomas T; Manzo, Teresa et al. (2013) The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells. Immunity 38:237-49|
|Strle, Klemen; Shin, Junghee J; Glickstein, Lisa J et al. (2012) Association of a Toll-like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic-refractory Lyme arthritis. Arthritis Rheum 64:1497-507|
|Castelino, Flavia V; Seiders, Jon; Bain, Gretchen et al. (2011) Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma. Arthritis Rheum 63:1405-15|
|Campanella, Gabriele S V; Colvin, Richard A; Luster, Andrew D (2010) CXCL10 can inhibit endothelial cell proliferation independently of CXCR3. PLoS One 5:e12700|
|Shen, Shiqian; Shin, Junghee J; Strle, Klemen et al. (2010) Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis. Arthritis Rheum 62:2127-37|
|Jones, Kathryn L; McHugh, Gail A; Glickstein, Lisa J et al. (2009) Analysis of Borrelia burgdorferi genotypes in patients with Lyme arthritis: High frequency of ribosomal RNA intergenic spacer type 1 strains in antibiotic-refractory arthritis. Arthritis Rheum 60:2174-82|
|Jones, Kathryn L; Seward, Robert J; Ben-Menachem, Gil et al. (2009) Strong IgG antibody responses to Borrelia burgdorferi glycolipids in patients with Lyme arthritis, a late manifestation of the infection. Clin Immunol 132:93-102|
|Jones, Kathryn L; Muellegger, Robert R; Means, Terry K et al. (2008) Higher mRNA levels of chemokines and cytokines associated with macrophage activation in erythema migrans skin lesions in patients from the United States than in patients from Austria with Lyme borreliosis. Clin Infect Dis 46:85-92|
|Setty, Arathi R; Curhan, Gary; Choi, Hyon K (2007) Smoking and the risk of psoriasis in women: Nurses'Health Study II. Am J Med 120:953-9|
|Setty, Arathi R; Curhan, Gary; Choi, Hyon K (2007) Obesity, waist circumference, weight change, and the risk of psoriasis in women: Nurses'Health Study II. Arch Intern Med 167:1670-5|
Showing the most recent 10 out of 34 publications