The goal of this program at Washington University is to provide high quality research training in the biomedical investigation of the rheumatic diseases, with a focus on the characterization of basic immunological mechanisms. Now in its 31st year, the program has developed a research training environment conducive to the nurturing of young scientists as evidenced by the large number of researchers and academics who have trained here. The experience will occur under the direction of training faculty in six major areas relevant to the immunobiology of inflammatory diseases including: 1) Animal models of rheumatic diseases;2) Autoimmunity and tolerance;3) Inflammation, the complement system and the innate immune response;4) Antigen processing and MHC molecules 5) Immunoregulation and host defense;and 6) Receptor signaling and lymphocyte development. These predominantly bench investigations in a mentor's laboratory will explore the mechanisms of human and mouse immune and inflammatory responses. A goal of these studies and one that we have fulfilled in the past is to translate these bench based observations into meaningful explanations for the etiology and immunopathologic basis of human disease states. Training Faculty include primarily members of the Rheumatology Division in the Department of Medicine and of the Department of Pathology and Immunology. Both physician-scientist (M.D. and M.D., Ph.D.) and basic scientist (Ph.D.) preceptors form the Program Faculty who are dedicated to training the next generation of scientists dedicated to increasing our understanding of the immunobiology of inflammatory diseases. Trainees will also be required to attend seminars and conferences that are devoted to clinical and translational aspects of rheumatology. This aspect of the training program provides exposure to clinical issues and points out opportunities for new research directions. Thus, this program has a distinguished track record of training physician-scientists and will continue to produce high quality researchers interested in immunologic aspects of the rheumatic diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR007279-34
Application #
8261862
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Mancini, Marie
Project Start
1977-09-30
Project End
2014-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
34
Fiscal Year
2012
Total Cost
$139,759
Indirect Cost
$18,365
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Miner, Jonathan J; Diamond, Michael S (2016) Mechanisms of restriction of viral neuroinvasion at the blood-brain barrier. Curr Opin Immunol 38:18-23
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Morales, David J; Monte, Kristen; Sun, Lulu et al. (2015) Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice. J Virol 89:337-49
Miner, Jonathan J; Aw Yeang, Han Xian; Fox, Julie M et al. (2015) Chikungunya viral arthritis in the United States: a mimic of seronegative rheumatoid arthritis. Arthritis Rheumatol 67:1214-20
Milner, Joshua D; Vogel, Tiphanie P; Forbes, Lisa et al. (2015) Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations. Blood 125:591-9
Vogel, Tiphanie P; Milner, Joshua D; Cooper, Megan A (2015) The Ying and Yang of STAT3 in Human Disease. J Clin Immunol 35:615-23
Miner, Jonathan J; Daniels, Brian P; Shrestha, Bimmi et al. (2015) The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity. Nat Med 21:1464-72
Ketscher, Lars; Hannß, Ronny; Morales, David J et al. (2015) Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance. Proc Natl Acad Sci U S A 112:1577-82

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