The overall goal of the Academic Rheumatology and Clinical Immunology Training Program at UCSF is to provide advanced research training to qualified individuals with MD, MD/PhD, or PhD degrees who plan to pursue research careers related to the rheumatic and immune-mediated diseases. This program combines a broad array of research areas, outstanding research mentors, and advanced training that provides trainees with an environment in which they can learn state-of-the-art methods and techniques;how to investigate a problem in depth;what constitutes quality science;the latest scientific advances in their field of study;and understanding of and respect for the ethical conduct of research. The program emphasizes approaches to translating research discoveries into improved recognition, treatment and delivery of the rheumatic diseases. This training program takes advantage of the resources of the Rheumatology Divisions at Moffitt-Long University Hospital, San Francisco General Hospital, and the San Francisco VA Medical Center and integrates the UCSF Division of Pediatric Rheumatology to support training in both adult and pediatric rheumatology/immunology. The program also draws upon the strength of the UCSF Immunology Program to provide trainees with access to leading immunology researchers and a broad range of research and training opportunities in a highly collaborative environment. For the current renewal, the program has added new faculty, including several involved in translational research, further emphasizing the emphasis on disease-related research by the program and further increasing the diverse opportunities for translational research training that exist for trainees across the UCSF system, including the Rheumatology Program. For over three decades, this T32 training program has combined strength in basic biomedical research, health services research/outcomes research, research in genetic epidemiology of rheumatic diseases and in clinical research. More recently, the program has added new research programs and research mentors involved in translational research. This integration of these programs at UCSF through the Rheumatology Program creates an outstanding environment for collaboration among faculty and trainees. This training grant supports six highly qualified trainees through two or three years of rigorous scientific training, with the objective that they will successfully devoe their subsequent careers to the study of the rheumatic and immunologic diseases.

Public Health Relevance

The rheumatic and immune-mediated diseases are a diverse group of conditions that collectively result in a large burden of disease and chronic illness in ou country. The advances that have been made in diagnosis and treatment of these conditions have come from basic scientific and clinical research. Because future advances depend on the availability of a well- trained workforce of scientists and physician researchers with expertise in this area, the goal of this proposal is to provide ongoing funding for a highly successful training program in Rheumatology and Clinical Immunology.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Mancini, Marie
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
Zip Code
Richman, Nicole C; Yazdany, Jinoos; Graf, Jonathan et al. (2013) Extraarticular manifestations of rheumatoid arthritis in a multiethnic cohort of predominantly Hispanic and Asian patients. Medicine (Baltimore) 92:92-7
Baker-Lepain, Julie C; Lynch, John A; Parimi, Neeta et al. (2012) Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis. Arthritis Rheum 64:1457-65
Lawson, Erica F; Yazdany, Jinoos (2012) Healthcare quality in systemic lupus erythematosus: using Donabedian's conceptual framework to understand what we know. Int J Clin Rheumtol 7:95-107
Malladi, Arundathi S; Sack, Kenneth E; Shiboski, Stephen C et al. (2012) Primary Sjogren's syndrome as a systemic disease: a study of participants enrolled in an international Sjogren's syndrome registry. Arthritis Care Res (Hoboken) 64:911-8
Baker-LePain, Julie C; Lane, Nancy E (2012) Role of bone architecture and anatomy in osteoarthritis. Bone 51:197-203
Baker-LePain, Julie C; Nakamura, Mary C; Shepherd, John et al. (2011) Assessment of bone remodelling in childhood-onset systemic lupus erythematosus. Rheumatology (Oxford) 50:611-9
Baker-LePain, Julie C; Nakamura, Mary C; Lane, Nancy E (2011) Effects of inflammation on bone: an update. Curr Opin Rheumatol 23:389-95
Baker-LePain, Julie C; Luker, Kali R; Lynch, John A et al. (2011) Active shape modeling of the hip in the prediction of incident hip fracture. J Bone Miner Res 26:468-74
Baker-LePain, Julie C; Lane, Nancy E (2010) Relationship between joint shape and the development of osteoarthritis. Curr Opin Rheumatol 22:538-43
Baker-Lepain, Julie C; Stone, David H; Nakamura, Mary C et al. (2010) Clinical diagnosis of segmental arterial mediolysis: Differentiation from vasculitis and other mimics. Arthritis Care Res (Hoboken) :

Showing the most recent 10 out of 29 publications