This is an application to renew the Musculoskeletal Training Program at the Indiana University School of Medicine. The current application proposes to use recent developments to train both predoctoral and postdoctoral students in five areas significant to musculoskeletal research: Osteoporosis, Skeletal Biomechanics, Molecular Biology/Genetics, Osteoarthritis, and Implants. They request expansion of the postdoctoral training program from two positions to four positions, and the addition of three predoctoral positions to partner with the Biomedical Engineering program and two combined degree (M.D./Ph.D. and D.D.S./Ph.D.) programs on the Indianapolis campus. Under the direction of a mentor and a research committee, training will include didactic instruction, weekly seminars followed by roundtable discussion, exposure to visiting professors and research discussion clubs allowing the presentation and evaluation of new research data. The Program is administered by a Director and Associate Director, with advice from an Advisory Council composed of five of the training faculty. During the first five years of the Musculoskeletal Training Program all slots were filled, and they were able to recruit women (33%), underrepresented minorities (Hispanic, 16%), and clinical (33%) trainees. The six trainees were distributed among six different mentors representing five different departments. The four trainees in the program prior to the final year published or have submitted 19 peer reviewed papers, and have published 17 abstracts or presentations at scientific conferences. Two presentations were nominated for Young Investigator Awards by the ASBMR and the ORS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32AR007581-06
Application #
6452874
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Panagis, James S
Project Start
1996-05-01
Project End
2007-04-30
Budget Start
2002-05-01
Budget End
2003-04-30
Support Year
6
Fiscal Year
2002
Total Cost
$291,309
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Bajaj, Devendra; Geissler, Joseph R; Allen, Matthew R et al. (2016) Response to Courtney et al. Bone 89:77-79
Acevedo, Claire; Bale, Hrishikesh; Gludovatz, Bernd et al. (2015) Alendronate treatment alters bone tissues at multiple structural levels in healthy canine cortical bone. Bone 81:352-363
Bajaj, Devendra; Geissler, Joseph R; Allen, Matthew R et al. (2014) The resistance of cortical bone tissue to failure under cyclic loading is reduced with alendronate. Bone 64:57-64
Gallant, Maxime A; Brown, Drew M; Organ, Jason M et al. (2013) Reference-point indentation correlates with bone toughness assessed using whole-bone traditional mechanical testing. Bone 53:301-5
Green, J O; Diab, T; Allen, M R et al. (2012) Three years of alendronate treatment does not continue to decrease microstructural stresses and strains associated with trabecular microdamage initiation beyond those at 1 year. Osteoporos Int 23:2313-20
Allen, Matthew R; Erickson, Antonia M; Wang, Xiang et al. (2010) Morphological assessment of basic multicellular unit resorption parameters in dogs shows additional mechanisms of bisphosphonate effects on bone. Calcif Tissue Int 86:67-71
Gourion-Arsiquaud, Samuel; Allen, Matthew R; Burr, David B et al. (2010) Bisphosphonate treatment modifies canine bone mineral and matrix properties and their heterogeneity. Bone 46:666-72
Siegmund, Thomas; Allen, Matthew R; Burr, David B (2010) Can deterministic mechanical size effects contribute to fracture and microdamage accumulation in trabecular bone? J Theor Biol 265:202-10
O'Neal, Jessica M; Diab, Tamim; Allen, Matthew R et al. (2010) One year of alendronate treatment lowers microstructural stresses associated with trabecular microdamage initiation. Bone 47:241-7
Imel, Erik A; DiMeglio, Linda A; Hui, Siu L et al. (2010) Treatment of X-linked hypophosphatemia with calcitriol and phosphate increases circulating fibroblast growth factor 23 concentrations. J Clin Endocrinol Metab 95:1846-50

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