This competitive renewal Institutional Training Grant application demonstrates the substantial strengths of the Department of Dermatology at Emory University in basic and clinical biomedical research, as well as those of its collaborating departments. The interdisciplinary nature of research in biology and disease at Emory is marked by a close interaction between Dermatology and investigators in other departments that is reinforced by substantial joint funding mechanisms. This collaborative and interdisciplinary effort in research not only enhances the breadth and quality of discovery in cutaneous biology and skin disease; it also provides a rich and stimulating training environment for developing the talents of young physicians and biomedical investigators. Through the second and most recent funding cycle, this training grant has continued to build upon the solid foundation established in its first funding cycle. The Emory Department of Dermatology has risen from relative obscurity with respect to its biomedical research and-clinical and research training programs to be rated as one of the best academic programs in the country. We have established a multidisciplinary Program Faculty that serve as preceptors and advisors to trainees, and these faculty have been extremely successful in obtaining peer-reviewed competitive funding and in training productive researchers and academic dermatologists. We have developed a multi-faceted educational program for trainees that ensure their exposure and training in basic and clinical research skills and approaches, critical thinking, writing and presentation, responsible conduct of research, and the peer review process. We are dedicated to training the next generation of leaders in cutaneous biology and skin disease research. Continued support of our integrated Research Training Program in Dermatology at Emory will greatly facilitate accomplishment of that goal. We believe that continuation of our Dermatology Research Training Program through renewal of this Institutional Training Grant will provide a unique training experience and expertise that will result in the emergence of well-trained, critically thinking, physician scientists who will enter into academic careers in Dermatology and cutaneous biology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32AR007587-11
Application #
6749972
Study Section
Special Emphasis Panel (ZAR1-YZW-G (J1))
Program Officer
Moshell, Alan N
Project Start
1994-07-01
Project End
2009-04-30
Budget Start
2004-05-01
Budget End
2005-04-30
Support Year
11
Fiscal Year
2004
Total Cost
$177,675
Indirect Cost
Name
Emory University
Department
Dermatology
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Cartee, Todd V; White, Kellie J; Newton-West, Marvin et al. (2012) Hypoxia and hypoxia mimetics inhibit TNF-dependent VCAM1 induction in the 5A32 endothelial cell line via a hypoxia inducible factor dependent mechanism. J Dermatol Sci 65:86-94
Jennings, Jean M; Tucker, Dana K; Kottke, Margaret D et al. (2011) Desmosome disassembly in response to pemphigus vulgaris IgG occurs in distinct phases and can be reversed by expression of exogenous Dsg3. J Invest Dermatol 131:706-18
Seidler, Anne M; Bramlette, Tracy B; Washington, Carl V et al. (2009) Mohs versus traditional surgical excision for facial and auricular nonmelanoma skin cancer: an analysis of cost-effectiveness. Dermatol Surg 35:1776-87
Gira, Amy K; Kowalczyk, Andrew P; Feng, Yue et al. (2009) Iron chelators and hypoxia mimetics inhibit IFNgamma-mediated Jak-STAT signaling. J Invest Dermatol 129:723-9
Spinler, Jennifer K; Zajdowicz, Sheryl L W; Haller, Jon C et al. (2009) Development and use of a selectable, broad-host-range reporter transposon for identifying environmentally regulated promoters in bacteria. FEMS Microbiol Lett 291:143-50
Delva, Emmanuella; Jennings, Jean Marie; Calkins, Catharine C et al. (2008) Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin- and dynamin-independent mechanism. J Biol Chem 283:18303-13
Berger, Adam C; Salazar, Gloria; Styers, Melanie L et al. (2007) The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3. J Cell Sci 120:3640-52
Bramlette, Tracy B; Lawson, David H; Washington, Carl V et al. (2007) Interferon Alfa-2b or not 2b? Significant differences exist in the decision-making process between melanoma patients who accept or decline high-dose adjuvant interferon Alfa-2b treatment. Dermatol Surg 33:11-6
Procaccio, Vincent; Salazar, Gloria; Ono, Shoichiro et al. (2006) A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia. Am J Hum Genet 78:947-60
Salazar, G; Craige, B; Styers, M L et al. (2006) BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes. Mol Biol Cell 17:4014-26

Showing the most recent 10 out of 18 publications