The overall objective of this research training program is to provide a broad investigational experience in laboratory or non-laboratory research related to rheumatic diseases. The Program focuses on autoimmunity and the connective tissue diseases. Formal curricula as well as an interdisciplinary emphasis on disease pathogenesis provide a structure for the training program. The program is designed to provide cross- fertilization between individuals with a basic science background and those with clinical training. Pre- doctoral candidates (three positions requested) and postdoctoral fellows (two positions requested) may select mentors from a diverse clinical and basic science faculty. The infrastructure for carrying out clinical research is enhanced by the University's GCRC and the recently funded CTSA. The program in systemic autoimmune disease (lupus, Sjogren's syndrome, rheumatoid arthritis) is the largest GCRC user. Training opportunities in clinical/translational research were strengthened through faculty recruitment over the past funding period. Research interests of the training faculty fall into the following categories: 1) Myeloid cell function, 2) lymphocyte biology, 3) animal models, 4) immunotherapy, cytokines, chemokines, 5) clinical immunology/biomarkers, 6) stem cell biology, 7) genetics/epigenetics of autoimmune disease, and 8) gene/cell therapy. The training program is largely preceptorial, with more than 75% of the trainee's time devoted to independent research activities and the rest spent in formal courses and conferences. The curriculum is tailored to trainees'individual needs. The Faculty has a strong track record of active collaboration. Participating departments are Medicine;Pediatrics;Pathology, Immunology &Laboratory Medicine;Molecular Genetics &Microbiology;Biochemistry &Molecular Biology;Epidemiology &Biostatistics;Health Policy &Epidemiology;Oral Biology;and Oral Surgery. Trainees completing the program over the past 5 and 10-year periods have been highly successful in terms of research publications and their subsequent career development, and 6 of 11 individuals who have completed their training have assumed positions in academia and 3 in industry.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32AR007603-11
Application #
7850363
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Mancini, Marie
Project Start
1998-05-01
Project End
2015-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
11
Fiscal Year
2010
Total Cost
$235,336
Indirect Cost
Name
University of Florida
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Tahiliani, Vikas; Hutchinson, Tarun E; Abboud, Georges et al. (2017) OX40 Cooperates with ICOS To Amplify Follicular Th Cell Development and Germinal Center Reactions during Infection. J Immunol 198:218-228
Abboud, Georges; Desai, Pritesh; Dastmalchi, Farhad et al. (2016) Tissue-specific programming of memory CD8 T cell subsets impacts protection against lethal respiratory virus infection. J Exp Med 213:2897-2911
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Zhuang, Haoyang; Han, Shuhong; Xu, Yuan et al. (2014) Toll-like receptor 7-stimulated tumor necrosis factor ? causes bone marrow damage in systemic lupus erythematosus. Arthritis Rheumatol 66:140-51
Nahid, Md A; Yao, Bing; Dominguez-Gutierrez, Paul R et al. (2013) Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212. J Immunol 190:1250-63

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