The proposed program is designed to train physicians interested in biomedical research in the area of the rheumatic diseases. The training program will consist primarily of a laboratory experience under the close supervision of a preceptor working on immunologic, molecular biologic, or biochemical problems relevant to the rheumatic diseases. A period of clinical experience will be offered in rheumatology. All trainees will take a course in scientific ethics and a course in scientific methodology. Other formal academic course work is available for those interested but will be at the discretion of the trainee and preceptor. Trainees will generally be physicians who have completed one year of internship and two or more years of housestaff training, usually in general internal medicine. Trainees will be chosen on the basis of their prior academic performance and record of housestaff achievement. Preference will be given to those with acknowledged research interest and demonstrated capacities in research. Four postdoctoral fellows will be selected to participate in the three-year fellowship. At the completion of training, they will be prepared to compete successfully for full-time academic positions in medical schools or research institutes. They anticipate that the majority will operate as rheumatologists within departments of medicine. The primary training unit will be the Rheumatology, Allergy and Immunology Division, Department of Medicine, University of California; and San Diego, School of Medicine. Training can be obtained in research laboratories located at the Basic Science and Clinical Sciences Buildings located in La Jolla or the San Diego Veterans Administration Medical Center also located in La Jolla. Inpatient and outpatient facilities are available at the UCSD Medical Center, the VA Medical Center, and the Thornton Hospital. The first two hospitals have, in addition, a Clinical Research Center for hospitalization of patients participating in investigational programs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
1T32AR007608-01A1
Application #
6313508
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Ader, Deborah N
Project Start
2001-06-10
Project End
2006-04-30
Budget Start
2001-06-10
Budget End
2002-04-30
Support Year
1
Fiscal Year
2001
Total Cost
$153,845
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Wu, Raymond P; Hayashi, Tomoko; Cottam, Howard B et al. (2010) Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 107:7479-84
Husa, Matthew; Liu-Bryan, Ru; Terkeltaub, Robert (2010) Shifting HIFs in osteoarthritis. Nat Med 16:641-4
Ablooglu, Ararat J; Kang, Jian; Petrich, Brian G et al. (2009) Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets. Blood 113:3585-92
Helsten, Teresa L; Bunch, Thomas A; Kato, Hisashi et al. (2008) Differences in regulation of Drosophila and vertebrate integrin affinity by talin. Mol Biol Cell 19:3589-98
Ablooglu, Ararat J; Kang, Jian; Handin, Robert I et al. (2007) The zebrafish vitronectin receptor: characterization of integrin alphaV and beta3 expression patterns in early vertebrate development. Dev Dyn 236:2268-76
Hammaker, Deepa R; Boyle, David L; Chabaud-Riou, Martine et al. (2004) Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis. J Immunol 172:1612-8