This proposal is a competitive renewal of a National Research Service Award for Rheumatology Research Training at Northwestern University Feinberg School of Medicine. This request responds to the ongoing, compelling need for Rheumatology research training by providing organized leadership and infrastructure for rigorous mentored research and didactic experiences, all of which have proven to be successful in the current funding period. The program builds on the strengths of current training initiatives in clinical and translational, public health and health services research and on the considerable scientific and research training experiences of Rheumatology faculty and collaborators from a wide variety of medical school departments, centers, and institutes. This request for renewal of the T32 in Rheumatology research comes at a time of substantial and sustained growth in the research enterprise of Feinberg School of Medicine. The long-term, overriding, goal of this training program is to nurture bright, enthusiastic, well-trained, academically-oriented M.D.s and Ph.D.s in their pursuit of a career in Rheumatology investigation, by enabling them to synthesize information about the complex issues associated with conducting scientifically and ethically sound research, and to maximize the likelihood that they will be competitive in seeking subsequent, independent research support. The specific objectives of this training grant are: 1) to develop clinical and basic research scientists, who will ultimately be capable of independently performing hypothesis-driven research that addresses the needs of out target patient population;2) to provide stipend support and protected time for research trainees;3) to sustain and improve an administrative structure that enhances the training environment;4) to provide both basic and clinical science trainees a rigorous base of classroom study in the disciplines necessary for successfully conducting research relevant to disease etiology, pathogenesis, outcomes, and for the provision of innovative care to patients with arthritis, musculoskeletal, and autoimmune disorders;5) to continue an ongoing evaluation process, modifying the program when appropriate to fully meet its goals and objectives.

Public Health Relevance

There is a critical need to train highly competent M.D. and Ph.D. investigators to conduct patient-oriented research leading to improved care for patients with arthritis and related conditions. The shortage of clinical research trainees has reached crisis proportions in academic medicine and this urgent situation is especially pertinent for Rheumatology research trainees. The long-term, overriding, goal of the Northwestern University Rheumatology Research Training Program is to nurture motivated, bright, enthusiastic, well-trained, academically-oriented M.D.s and Ph.D.s in their pursuit of careers in Rheumatology investigation, training them to become the next generation of leaders in research.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Mao, Su-Yau
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Northwestern University at Chicago
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Reinke, Lauren; Lam, Anna P; Flozak, Annette S et al. (2016) Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling. Biochem Biophys Res Commun 470:606-12
Mahieu, M A; Strand, V; Simon, L S et al. (2016) A critical review of clinical trials in systemic lupus erythematosus. Lupus 25:1122-40
Archer, Amy M; Saber, Rana; Rose, Shawn et al. (2016) ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model. J Transl Med 14:170
Mahieu, M A; Ahn, G E; Chmiel, J S et al. (2016) Fatigue, patient reported outcomes, and objective measurement of physical activity in systemic lupus erythematosus. Lupus 25:1190-9
Silverberg, Jonathan I; Song, Jing; Pinto, Daniel et al. (2016) Atopic Dermatitis Is Associated with Less Physical Activity in US Adults. J Invest Dermatol 136:1714-6
Gilbert, Abigail L; Lee, Jungwha; Ma, Madeleine et al. (2016) Comparison of Subjective and Objective Measures of Sedentary Behavior Using the Yale Physical Activity Survey and Accelerometry in Patients With Rheumatoid Arthritis. J Phys Act Health 13:371-6
Mahieu, Mary; Yount, Susan; Ramsey-Goldman, Rosalind (2016) Patient-Reported Outcomes in Systemic Lupus Erythematosus. Rheum Dis Clin North Am 42:253-63
de Almeida, Lucia; Khare, Sonal; Misharin, Alexander V et al. (2015) The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease. Immunity 43:264-76
Khare, Sonal; Ratsimandresy, Rojo A; de Almeida, Lúcia et al. (2014) The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. Nat Immunol 15:343-53
Lin, Pin; Rhew, Elisa; Ness, Roberta B et al. (2014) Adverse pregnancy outcomes and subsequent risk of cardiovascular disease in women with systemic lupus erythematosus. Lupus Sci Med 1:e000024

Showing the most recent 10 out of 33 publications