There continues to be growing recognition that exercise and inactivity can play important roles in many disease processes. The goal of this training grant proposal is to establish a strong and rich research training environmentfor those M.D.s and Ph.D.s interested in exercise science. The underlyingprogrammatic theme of this trainingprogram is that of """"""""integrative/translational"""""""" science. Withinthis context, the prgoram consists of two core groups: the Molecular Physiology Core Group and the Systems Physiology Core Group. The emphasis of these cores is in skeletal muscle, cardiovascular, and respiratory physiology given that these areas of research represent the focus of the Program Faculty, and represent areas of extensive on-going interactions. An integrated/translational approach is especially important in exercise science because of the profound role that physical activity is now known to play in human health. Postdoctoral fellows will interact with the faculty and other trainees through a formal didactic program, seminars, journal clubs, and research-in-progress discussions. At the beginningof the program each fellow will work with the Executive Committee to select a primary and secondary research emphasis designed to reflect an appropriate diversity of topics in exercise science. These emphases will be selected from the two cores. Trainees will become familiar with a variety of animal and cell model systems and state-of-the-art approaches to human performance testing, thereby facilitating the translation from these systems to human research and, ultimately to clinical applications. For this latter objective, Human Performance Laboratory at the U.C. Irvine GCRC/CTSC will play an importantrole as it is funded specifically to support translational research in an environmentthat optimizesthe safety and quality of human investigation. The Program Faculty have a history of collaborative research with each other and are currently involved in training postdoctoral research fellows. This proposed training program is designed to introduce postdoctoral trainees to new disciplines as they continueto hone skills and approaches mastered in the predoctoral years. For postdoctoral MD.s, the program will attract individuals seriously interested in becoming independent investigators. Exercise physiology is not a separate ACGME-recognized specialty or subspecialty;consequently, MDs pursuingpostdoctoral training in this program must be committed to academic careers. For Ph.D.s, the program will be best suited for basic scientists who see their academic careers involving clinical interaction either through direct human research or as members of faculties of medical schools where translational research activity is likelyto be encouraged.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR047752-10
Application #
8262712
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Boyce, Amanda T
Project Start
2001-04-01
Project End
2013-11-30
Budget Start
2012-05-01
Budget End
2013-11-30
Support Year
10
Fiscal Year
2012
Total Cost
$182,325
Indirect Cost
$17,340
Name
University of California Irvine
Department
Orthopedics
Type
Schools of Medicine
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Cassidy, Jessica M; Cramer, Steven C (2016) Spontaneous and Therapeutic-Induced Mechanisms of Functional Recovery After Stroke. Transl Stroke Res :
Williams, Cassondra L; Hicks, James W (2016) Continuous arterial PO2 profiles in unrestrained, undisturbed aquatic turtles during routine behaviors. J Exp Biol 219:3616-3625
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Cassidy, Jessica M; Chu, Haitao; Anderson, David C et al. (2015) A Comparison of Primed Low-frequency Repetitive Transcranial Magnetic Stimulation Treatments in Chronic Stroke. Brain Stimul 8:1074-84
Ganesan, Goutham; Cotter, Joshua A; Reuland, Warren et al. (2015) Effect of blood flow restriction on tissue oxygenation during knee extension. Med Sci Sports Exerc 47:185-93
Cotter, Joshua A; Yu, Alvin; Haddad, Fadia et al. (2015) Concurrent exercise on a gravity-independent device during simulated microgravity. Med Sci Sports Exerc 47:990-1000
Cassidy, Jessica M; Carey, James R; Lu, Chiahao et al. (2015) Ipsilesional motor-evoked potential absence in pediatric hemiparesis impacts tracking accuracy of the less affected hand. Res Dev Disabil 47:154-64
Abosaida, Alladdin; Chen, Jen Jen; Nussbaum, Eliezer et al. (2015) Vigorous Exercise Can Cause Abnormal Pulmonary Function in Healthy Adolescents. Ann Am Thorac Soc 12:872-7

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