This proposal is a competitive renewal application for a National Research Service Award Institutional Research Training Grant (T32) to further support a Multidisciplinary Rheumatology Training Program at Johns Hopkins. Over the past 4 years, the program has demonstrated outstanding trainee achievement, in the areas of publications, appointment to faculty positions after training, and a very high rate of acquisition f independent, peer-reviewed funding. We demonstrate that the overall trajectory of this program remains steeply positive, with outstanding divisional and institutional resources available to postdoctoral fellows in rheumatology, continued growth and enhancement of the program faculty, and a pool of highly competitive applicants (including women and under-represented minorities). The program has very engaged and highly expert internal and external advisory committees, who provide real-time advice about the program's priorities, systems and directions. Members of the program faculty have a breadth of interests and expertise, and are proven mentors in the rheumatic diseases, immunology, molecular biology and genetics, cell biology, epidemiology and biostatistics. The overall goal of this program remains the development of 2 postdoctoral fellows each year (4 trainee slots total) into outstanding academic investigators in rheumatic disease, through rigorous instruction in research methodology and immersion in outstanding quality mentored research projects. Our training environment is focused on providing a productive clinical and translational research training program. The following specific aims will be pursued: [1] Provide rigorous training in investigational methods to rheumatology postdoctoral fellows, applicable to the conduct of both clinical and basic research;[2] Utilize clinical centers of excellence to provide access to well-defined rheumatic disease patient populations, enabling fellow projects to be efficiently conducted on established patient cohorts;[3] Engage postdoctoral fellows in high caliber research projects addressing important questions under the supervision of nationally renowned faculty;[4] Integrate multi-layered mentorship for each postdoctoral fellow to accomplish productive research, independence, and development of a successful academic career;and [5] Assess, and modify as needed (through incorporating feedback from trainees, training program faculty, and internal and external advisory committees), the outcomes of this training environment through assessing benchmarks of academic and programmatic achievement, including peer-reviewed publications, external research funding, post-training academic position, and recruitment of underrepresented minorities.

Public Health Relevance

In aggregate, the Rheumatic diseases pose a major challenge to US health, due to their frequency, morbidity and resulting disability. Improving diagnosis, monitoring therapy and prevention of these diseases requires a highly expert group of investigators. Training such investigators is the major focus of this program.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Institutional National Research Service Award (T32)
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Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
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Mancini, Marie
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Johns Hopkins University
Internal Medicine/Medicine
Schools of Medicine
United States
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Orbai, A-M; Truedsson, L; Sturfelt, G et al. (2015) Anti-C1q antibodies in systemic lupus erythematosus. Lupus 24:42-9
Alexanderson, Helene; Del Grande, Maria; Bingham 3rd, Clifton O et al. (2014) Patient-reported outcomes and adult patients' disease experience in the idiopathic inflammatory myopathies. report from the OMERACT 11 Myositis Special Interest Group. J Rheumatol 41:581-92
Stojan, George; Illei, Peter B; Yung, Rex C et al. (2014) Raynaud's phenomenon, inflammatory arthritis, and weight loss: pay attention to the man behind the curtain. Arthritis Care Res (Hoboken) 66:1263-8
Darrah, Erika; Giles, Jon T; Ols, Michelle L et al. (2013) Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity. Sci Transl Med 5:186ra65
Smith, Lanaya Williams; Petri, Michelle (2013) Lupus enteritis: an uncommon manifestation of systemic lupus erythematosus. J Clin Rheumatol 19:84-6
Smith, Lanaya Williams; Gelber, Allan C; Petri, Michelle (2013) Diffuse lymphadenopathy as the presenting manifestation of systemic lupus erythematosus. J Clin Rheumatol 19:397-9
Ferucci, Elizabeth D; Darrah, Erika; Smolik, Irene et al. (2013) Prevalence of anti-peptidylarginine deiminase type 4 antibodies in rheumatoid arthritis and unaffected first-degree relatives in indigenous North American Populations. J Rheumatol 40:1523-8
Stojan, George; Petri, Michelle (2013) Atherosclerosis in systemic lupus erythematosus. J Cardiovasc Pharmacol 62:255-62
Darrah, Erika; Rosen, Antony; Giles, Jon T et al. (2012) Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis. Ann Rheum Dis 71:92-8
Petri, Michelle; Orbai, Ana-Maria; Alarcón, Graciela S et al. (2012) Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 64:2677-86

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