This proposal is a competitive renewal application for a National Research Service Award Institutional Research Training Grant (T32) to further support a Multidisciplinary Rheumatology Training Program at Johns Hopkins. Over the past 4 years, the program has demonstrated outstanding trainee achievement, in the areas of publications, appointment to faculty positions after training, and a very high rate of acquisition f independent, peer-reviewed funding. We demonstrate that the overall trajectory of this program remains steeply positive, with outstanding divisional and institutional resources available to postdoctoral fellows in rheumatology, continued growth and enhancement of the program faculty, and a pool of highly competitive applicants (including women and under-represented minorities). The program has very engaged and highly expert internal and external advisory committees, who provide real-time advice about the program's priorities, systems and directions. Members of the program faculty have a breadth of interests and expertise, and are proven mentors in the rheumatic diseases, immunology, molecular biology and genetics, cell biology, epidemiology and biostatistics. The overall goal of this program remains the development of 2 postdoctoral fellows each year (4 trainee slots total) into outstanding academic investigators in rheumatic disease, through rigorous instruction in research methodology and immersion in outstanding quality mentored research projects. Our training environment is focused on providing a productive clinical and translational research training program. The following specific aims will be pursued: [1] Provide rigorous training in investigational methods to rheumatology postdoctoral fellows, applicable to the conduct of both clinical and basic research;[2] Utilize clinical centers of excellence to provide access to well-defined rheumatic disease patient populations, enabling fellow projects to be efficiently conducted on established patient cohorts;[3] Engage postdoctoral fellows in high caliber research projects addressing important questions under the supervision of nationally renowned faculty;[4] Integrate multi-layered mentorship for each postdoctoral fellow to accomplish productive research, independence, and development of a successful academic career;and [5] Assess, and modify as needed (through incorporating feedback from trainees, training program faculty, and internal and external advisory committees), the outcomes of this training environment through assessing benchmarks of academic and programmatic achievement, including peer-reviewed publications, external research funding, post-training academic position, and recruitment of underrepresented minorities.

Public Health Relevance

In aggregate, the Rheumatic diseases pose a major challenge to US health, due to their frequency, morbidity and resulting disability. Improving diagnosis, monitoring therapy and prevention of these diseases requires a highly expert group of investigators. Training such investigators is the major focus of this program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR048522-12
Application #
8660035
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Mancini, Marie
Project Start
2002-07-01
Project End
2018-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
12
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Cappelli, Laura C; Palmer, Judy Lynn; Kremer, Joel et al. (2017) Tocilizumab treatment leads to improvement in disease activity regardless of CCP status in rheumatoid arthritis. Semin Arthritis Rheum 47:165-169
Craig, Ethan T; Sedighi Manesh, Reza; Cuda, Jonathan D et al. (2017) Labial Pain, Swelling and Fever: An Autoinflammatory Disorder. Am J Med 130:662-665
Adler, Brittany L; Albayda, Jemima; Shores, Jamie T et al. (2017) Erosive Rheumatoid Arthritis After Bilateral Hand Transplantation. Ann Intern Med 167:216-218
Morgan, Nadia D; Hummers, Laura K (2016) Scleroderma Mimickers. Curr Treatm Opt Rheumatol 2:69-84
Floyd, James S; Brody, Jennifer A; Tiniakou, Eleni et al. (2016) Absence of anti-HMG-CoA reductase autoantibodies in severe self-limited statin-related myopathy. Muscle Nerve 54:142-4
Hinze, Alicia M; Louie, Grant H (2016) Osteoporosis Management in Ankylosing Spondylitis. Curr Treatm Opt Rheumatol 2:271-282
Ligon, Colin; Hummers, Laura K (2016) Biomarkers in Scleroderma: Progressing from Association to Clinical Utility. Curr Rheumatol Rep 18:17
Baer, Alan N; Kurano, Tracie; Thakur, Uma J et al. (2016) Dual-energy computed tomography has limited sensitivity for non-tophaceous gout: a comparison study with tophaceous gout. BMC Musculoskelet Disord 17:91
Zollars, Eric; Courtney, Sean M; Wolf, Bethany J et al. (2016) Clinical Application of a Modular Genomics Technique in Systemic Lupus Erythematosus: Progress towards Precision Medicine. Int J Genomics 2016:7862962
Mecoli, Christopher A; Delev, Nikolay G; Bingham 3rd, Clifton O (2016) Measuring transaminases in patients with rheumatoid arthritis on weekly methotrexate: does timing of blood testing matter? Clin Rheumatol 35:3053-3056

Showing the most recent 10 out of 46 publications