The focus of the renewal of the Training Program in Tissue Engineering and Regenerative Medicine is to provide doctoral students with advanced training in biomedical research. The didactic portion of the Program provides an integrated, innovative and rigorous educational experience that has as its goal the repair or regeneration of human tissues and organs and the preservation of the quality of human health. Resources for the program come from a core of well-funded faculty in several departments/divisions at Thomas Jefferson University including Orthopaedic Surgery, Dermatology, Medicine, Surgery, Anatomy and Developmental Biology, Stem Cell Biology, Pathology and Cell Biology and the Rothman Institute. We request support for five predoctoral students in the 01-03 year of the grant and six students in the 04-05 years. There are six program objectives: (1) to integrate contemporary advances in cell, molecular, and developmental biology towards understanding tissue function;(2) to relate fundamental advances in the life sciences to contemporary issues in tissue engineering (3) to foster practical understandings of the pathophysiology of diseases of the skeleton;(4) to develop translational research by working closely with physicians in a clinical and surgical setting;(5) to implement translational research through interactions with scientists in the biotech industry and (6) to build a pipeline of talented individuals for careers in musculoskeletal research The didactic aspects of the training program are embedded in integrating developmental, cell and molecular biology;bioinformatics and functional genomics;tissue engineering and bioimaging;and translational medicine. So as to anchor the program in human disease, clinicians lecture in each of the major courses. By interacting frequently with surgeons who treat the ravages of disease, and by direct observation and discussion with faculty in the clinic and operating room, students develop an appreciation for health problems that are amenable to treatment by tissue engineering and regenerative medicine. Development of translational research is furthered by collaboration with scientists at local biotech companies and laboratories. Against this background, students develop their dissertation research which provides the foundation for their future careers as independent, innovative scientific investigators.
The focus of the renewal of the Training Program in Tissue Engineering and Regenerative Medicine is to provide doctoral students with advanced training in biomedical research, with special emphasis on diseases that afflict the skeleton. Against this background, students develop their dissertation research which provides the foundation for their future careers as independent, innovative scientific investigators.
|Schoepflin, Zachary R; Shapiro, Irving M; Risbud, Makarand V (2016) Class I and IIa HDACs Mediate HIF-1Î± Stability Through PHD2-Dependent Mechanism, While HDAC6, a Class IIb Member, Promotes HIF-1Î± Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc. J Bone Miner Res 31:1287-99|
|Wang, Xia; Chen, Dongying; Chen, Kelley et al. (2016) Endothelium in the pharyngeal arches 3, 4 and 6 is derived from the second heart field. Dev Biol :|
|Zhang, Qian-Shi; Eaton, Gregory J; Diallo, Carol et al. (2016) Stress-Induced Activation of Apoptosis Signal-Regulating Kinase 1 Promotes Osteoarthritis. J Cell Physiol 231:944-53|
|Choi, Hyowon; Johnson, Zariel I; Risbud, Makarand V (2015) Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration. Curr Stem Cell Res Ther 10:307-16|
|Dastgheyb, Sana; Parvizi, Javad; Shapiro, Irving M et al. (2015) Effect of biofilms on recalcitrance of staphylococcal joint infection to antibiotic treatment. J Infect Dis 211:641-50|
|Dastgheyb, Sana S; Villaruz, Amer E; Le, Katherine Y et al. (2015) Role of Phenol-Soluble Modulins in Formation of Staphylococcus aureus Biofilms in Synovial Fluid. Infect Immun 83:2966-75|
|Dastgheyb, Sana S; Hammoud, Sommer; Ketonis, Constantinos et al. (2015) Staphylococcal persistence due to biofilm formation in synovial fluid containing prophylactic cefazolin. Antimicrob Agents Chemother 59:2122-8|
|Dastgheyb, Sana S; Toorkey, Cyrus B; Shapiro, Irving M et al. (2015) Porphyrin-adsorbed Allograft Bone: A Photoactive, Antibiofilm Surface. Clin Orthop Relat Res 473:2865-73|
|Jimbo, Masaya; Blanco, Fernando F; Huang, Yu-Hung et al. (2015) Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells. Oncotarget 6:27312-31|
|Johnson, Z I; Schoepflin, Z R; Choi, H et al. (2015) Disc in flames: Roles of TNF-Î± and IL-1Î² in intervertebral disc degeneration. Eur Cell Mater 30:104-16; discussion 116-7|
Showing the most recent 10 out of 25 publications