The muscle and motility community at the University of Pennsylvania proposes to establish a training program in Muscle Biology and Muscle Disease, to be supported in part by the T32 mechanism. Members of the Penn community are known world-wide for excellence in muscle research, yet a unified muscle training program does not currently exist. There are no T32-related muscle biology grants at the University of Pennsylvania. Therefore, we developed a, new training program that includes new graduate-level courses that relate directly to training in muscle biology and disease. Our proposed training program would support 2 predoctoral students and 2 postdoctoral students, enabling them to work in any of 20 laboratories directed by principal investigators who are leaders in the study of the cell biology, genetics, physiology, and/or pathology of muscle. Although the range of interests and expertise of the trainers on this grant is broad, the training is focused on elucidating the mechanisms of muscle function and disease. The program is designed to take advantage of the highly collaborative nature of the faculty, thus providing the trainees with the opportunity to integrate molecular and clinical aspects of muscle biology into their research. This diversity provides for the potential for an unparalleled training environment in the area of muscle biology. This is evidenced by the many prominent scientists around the world who have trained in this field at the University of Pennsylvania.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR053461-05
Application #
7806415
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Boyce, Amanda T
Project Start
2006-05-01
Project End
2011-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
5
Fiscal Year
2010
Total Cost
$203,855
Indirect Cost
Name
University of Pennsylvania
Department
Physiology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Szczesny, Spencer E; Driscoll, Tristan P; Tseng, Hsiao-Yun et al. (2017) Crimped Nanofibrous Biomaterials Mimic Microstructure and Mechanics of Native Tissue and Alter Strain Transfer to Cells. ACS Biomater Sci Eng 3:2869-2876
Tucker, Jennica J; Cirone, James M; Morris, Tyler R et al. (2017) Pulsed electromagnetic field therapy improves tendon-to-bone healing in a rat rotator cuff repair model. J Orthop Res 35:902-909
Robison, Patrick; Prosser, Benjamin L (2017) Microtubule mechanics in the working myocyte. J Physiol 595:3931-3937
Szczesny, Spencer E; Mauck, Robert L (2017) The Nuclear Option: Evidence Implicating the Cell Nucleus in Mechanotransduction. J Biomech Eng 139:
Song, Yafeng; Rosenblum, Shira T; Morales, Leon et al. (2017) Suite of clinically relevant functional assays to address therapeutic efficacy and disease mechanism in the dystrophic mdx mouse. J Appl Physiol (1985) 122:593-602
McIntosh, Betsy B; Ostap, E Michael (2016) Myosin-I molecular motors at a glance. J Cell Sci 129:2689-95
Hammers, David W; Sleeper, Margaret M; Forbes, Sean C et al. (2016) Disease-modifying effects of orally bioavailable NF-?B inhibitors in dystrophin-deficient muscle. JCI Insight 1:e90341
Wilson, Meredith H; Bray, Matthew G; Holzbaur, Erika L F (2016) Methods for Assessing Nuclear Rotation and Nuclear Positioning in Developing Skeletal Muscle Cells. Methods Mol Biol 1411:269-90
Smith, Lucas R; Hammers, David W; Sweeney, H Lee et al. (2016) Increased collagen cross-linking is a signature of dystrophin-deficient muscle. Muscle Nerve 54:71-8
Rooney, Sarah Ilkhanipour; Baskin, Rachel; Torino, Daniel J et al. (2016) Ibuprofen Differentially Affects Supraspinatus Muscle and Tendon Adaptations to Exercise in a Rat Model. Am J Sports Med 44:2237-45

Showing the most recent 10 out of 53 publications