The goals of this Musculoskeletal Research Training Program are to provide multidisciplinary research opportunities for postdoctoral fellows, graduate students, and medical students at Mayo Clinic and to train them to be future leaders of biomedical research. Musculoskeletal ailments such as osteoarthritis, osteoporosis, back pain, and fractures are some of the most common reasons why patients visit a doctor and as such have significant effects on quality of life, as well as our economy. The repair, regeneration, or rejuvenation of musculoskeletal tissues and joints requires knowledge of complex and interconnected biomechanical, biological, and physiological processes. Thus, this program aims to train future biologists, engineers, and physicians/surgeons to solve orthopedic and musculoskeletal problems by providing outstanding research and educational opportunities within the setting of a state-of-the-art medical and research center. Nineteen faculty members who are leaders in basic, translational, and clinical research of orthopedics, endocrinology, infectious disease, and neuromuscular control will mentor trainees by directing research projects and group discussions on timely topics. A peer-mentoring system is also available for new trainees to receive advice and counseling from past trainees who successfully obtained independent fellowships. Postdoctoral fellows (4 per year) and graduate students (2 per year) will engage in multiyear projects and receive training in grant writing and career development. They will be expected to submit applications for independent fellowships and to participate if a full array of programmatic activities, including but not limited to journal clubs, seminars, webinars, national scientific meetings, and training in the responsible conduct of research. Medical students (2 per year) from fully accredited medical schools in the United States and its territories (i.e., Puerto Rico) will spend two to three months in the training program and be expected complete a defined research project under the guidance of a mentor(s) and to participate in didactic educational activities. This blended musculoskeletal research training program values individuals from diverse educational and societal backgrounds and benefits from the unique perspectives they bring to solving complex medical problems and reducing the burden of musculoskeletal diseases on patients, their families and our society.
Musculoskeletal diseases are the leading cause of disability in people over 50 years of age. The total economic costs for treatment and time spent away from work are estimated to be over $950 billion annually. The prevalence of musculoskeletal conditions will continue to escalate in the next 10 to 20 years due to the aging baby boomer population. This program provides focused training at Mayo Clinic to a new generation of researchers who will advance the science and treatment of musculoskeletal diseases.
|Ellingson, Arin M; Mozingo, Joseph D; Magnuson, Dixon J et al. (2016) Characterizing fluoroscopy based kinematic accuracy as a function of pulse width and velocity. J Biomech 49:3741-3745|
|Bonin, Carolina A; Lewallen, Eric A; Baheti, Saurabh et al. (2016) Identification of differentially methylated regions in new genes associated with knee osteoarthritis. Gene 576:312-8|
|Gustafson, Carl T; Boakye-Agyeman, Felix; Brinkman, Cassandra L et al. (2016) Controlled Delivery of Vancomycin via Charged Hydrogels. PLoS One 11:e0146401|
|Kremers, Hilal Maradit; Lewallen, Eric A; van Wijnen, Andre J et al. (2016) Clinical Factors, Disease Parameters, and Molecular Therapies Affecting Osseointegration of Orthopedic Implants. Curr Mol Biol Rep 2:123-132|
|McGee-Lawrence, Meghan E; Carpio, Lomeli R; Schulze, Ryan J et al. (2016) Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells. J Bone Miner Res 31:116-28|
|Lin, Yang; Lewallen, Eric A; Camilleri, Emily T et al. (2016) RNA-seq analysis of clinical-grade osteochondral allografts reveals activation of early response genes. J Orthop Res 34:1950-1959|
|Hatta, Taku; Giambini, Hugo; Hooke, Alexander W et al. (2016) Comparison of Passive Stiffness Changes in the Supraspinatus Muscle After Double-Row and Knotless Transosseous-Equivalent Rotator Cuff Repair Techniques: A Cadaveric Study. Arthroscopy 32:1973-1981|
|Go, Shanette A; Jensen, Elisabeth R; O'Connor, Shawn M et al. (2016) Design Considerations of a Fiber Optic Pressure Sensor Protective Housing for Intramuscular Pressure Measurements. Ann Biomed Eng :|
|Schilaty, Nathan D; Nagelli, Christopher; Hewett, Timothy E (2016) Use of Objective Neurocognitive Measures to Assess the Psychological States that Influence Return to Sport Following Injury. Sports Med 46:299-303|
|Lewallen, Eric A; Jones, Dakota L; Dudakovic, Amel et al. (2016) Osteogenic potential of human adipose-tissue-derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium. Gene 581:95-106|
Showing the most recent 10 out of 89 publications