The Burden of Skin Diseases 2005 (available at www.sidnet.org under Programs and Services) was presented to all NIH Directors documenting more than 3000 skin diseases with an estimated cost of $37 billion dollars per year in medical services and lost productivity. The Association of Professors of Dermatology (APD) and the American Academy of Dermatology (AAD) have recognized that while dermatology is currently attracting the top graduates from U.S. medical schools, there is a worrisome shortage in the workforce of academic dermatology. The mission of this proposed new Dermatology Institutional T32 Training Grant at the University of Washington is to train the next generation of independent investigators in dermatology and skin biology and is thus directly aligned with the training goals of NIAMS as articulated in 2007. This focused mission to train independent investigators (rather than a more broad mission of retaining trainees in academia) is one of many important components of this new application that differ from a T32 program that existed at the University of Washington from 1962 through 2005. The new Training Program will be organized around two formal tracks: Skin Biology Track (SBT) and Clinical Investigator Track (CIT). The SBT provides the opportunity for fellows to train with world-class investigators as they study skin biology using approaches that span the spectrum of biochemistry, protein chemistry, proteomics, imaging, ultrastructure, immunology, microbiology, innate immunity, biofilm biology, molecular and cell biology, transplantation biology, gene regulation, genomic research, chemical genetics, biomaterials and more. The CIT focuses on patient oriented research using methods of epidemiology and biostatistics for research in areas such as skin cancers, skin diseases, population genetics, health services delivery, medical education and teledermatology. Support is requested for 3 postdoctoral trainees with PhD, MD or MD/PhD degrees. A carefully structured plan for recruitment, selection and retention of trainees is described. A mentoring plan that includes formal written evaluations of both the mentee and the mentor is integral to this proposal. We have developed an aggressive, well funded program for applicant pool expansion, recruitment and retention of well qualified minority applicants. Likewise, a strong program is in place for teaching research integrity at the University of Washington.
The program stresses the conduct of research in an ethical and scientifically responsible manner and has an on-going commitment to attract individuals from under-represented minorities.
|Sontheimer, Clayton; Liggitt, Denny; Elkon, Keith B (2017) Ultraviolet B Irradiation Causes Stimulator of Interferon Genes-Dependent Production of Protective Type I Interferon in Mouse Skin by Recruited Inflammatory Monocytes. Arthritis Rheumatol 69:826-836|
|Zhao, Ge; Lee, Kachiu C; Peacock, Sue et al. (2017) The utilization of spitz-related nomenclature in the histological interpretation of cutaneous melanocytic lesions by practicing pathologists: results from the M-Path study. J Cutan Pathol 44:5-14|
|Zhao, Ge; Lee, Kachiu C; Kwon, Gina et al. (2016) The self-reported use of immunostains and cytogenetic testing in the diagnosis of melanoma by practicing U.S. pathologists of 10 selected states. J Cutan Pathol 43:492-7|
|Roan, Florence; Stoklasek, Thomas A; Whalen, Elizabeth et al. (2016) CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis. J Immunol 196:2051-2062|
|Church, Candice D; Nghiem, Paul (2015) How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions, and a new mouse model. J Invest Dermatol 135:1221-1224|
|Rohani, Maryam G; Pilcher, Brian K; Chen, Peter et al. (2014) Cdc42 inhibits ERK-mediated collagenase-1 (MMP-1) expression in collagen-activated human keratinocytes. J Invest Dermatol 134:1230-1237|
|James, Richard G; Bosch, Katherine A; Kulikauskas, Rima M et al. (2013) Protein kinase PKN1 represses Wnt/?-catenin signaling in human melanoma cells. J Biol Chem 288:34658-70|
|Conrad, William H; Swift, Reyna D; Biechele, Travis L et al. (2012) Regulating the response to targeted MEK inhibition in melanoma: enhancing apoptosis in NRAS- and BRAF-mutant melanoma cells with Wnt/*-catenin activation. Cell Cycle 11:3724-30|
|Biechele, Travis L; Kulikauskas, Rima M; Toroni, Rachel A et al. (2012) Wnt/?-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma. Sci Signal 5:ra3|
|James, Richard G; Davidson, Kathryn C; Bosch, Katherine A et al. (2012) WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling. PLoS One 7:e50457|
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