A new training grant (T32) for post-doctoral fellows in Genetics and Genomics of Muscle is described. Training faculty are drawn from Children's National Medical Center and University of Maryland. Research and training topics include muscular dystrophy, exercise physiology, muscle regeneration, and pre-clinical and clinical trials. Technological training Is in genome-enabled studies of muscle, such as genome-wide SNP association studies (GWAS), mRNA profiling, proteomic profiling, and systems biology. This technological bench training is heavily augmented with training in bioinformatics and statistics, and appropriate conduct of research. The proposed T32 is unique in the translational training for muscle in health and disease, with extensive pre-clinical and clinical trials. Integrative and systems biology are strengths of the preceptors, with extensive bioinformatics, statistics, and human/computer visualization training available to fellows. The proposed training program includes both didactic training in interdisciplinary approaches, as well as hands-on laboratory and computational training. The proposed training faculty are supported by a strong portfolio of investigator-initiated individual research grants and awards. A unique advantage of the proposed training program is the foundation of federally-funded Center and Core grants on muscle translational research that would provide rich core facilities and pilot funding opportunities for the proposed T32 fellows. These include a National Center for Medical Rehabilitation Research, Pediatric Pharmacology Research Unit, Wellstone Muscular Dystrophy Center, Cooperative International Neuromuscular Research Group clinical trial network, Department of Defense Program Project in Translational Research in the Muscular Dystrophies, and an Intellectual and Developmental Disabilities Center.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Institutional National Research Service Award (T32)
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Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
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Boyce, Amanda T
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Children's Research Institute
United States
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Hubal, Monica J; Nadler, Evan P; Ferrante, Sarah C et al. (2017) Circulating adipocyte-derived exosomal MicroRNAs associated with decreased insulin resistance after gastric bypass. Obesity (Silver Spring) 25:102-110
Novak, James S; Hogarth, Marshall W; Boehler, Jessica F et al. (2017) Myoblasts and macrophages are required for therapeutic morpholino antisense oligonucleotide delivery to dystrophic muscle. Nat Commun 8:941
Boehler, Jessica F; Hogarth, Marshall W; Barberio, Matthew D et al. (2017) Effect of endurance exercise on microRNAs in myositis skeletal muscle-A randomized controlled study. PLoS One 12:e0183292
Chesler, Alexander T; Szczot, Marcin; Bharucha-Goebel, Diana et al. (2016) The Role of PIEZO2 in Human Mechanosensation. N Engl J Med 375:1355-1364
Coley, William D; Bogdanik, Laurent; Vila, Maria Candida et al. (2016) Effect of genetic background on the dystrophic phenotype in mdx mice. Hum Mol Genet 25:130-45
Punetha, Jaya; Kesari, Akanchha; Uapinyoying, Prech et al. (2016) Targeted Re-Sequencing Emulsion PCR Panel for Myopathies: Results in 94 Cases. J Neuromuscul Dis 3:209-225
Hotchkiss, Leslie; Donkervoort, Sandra; Leach, Meganne E et al. (2016) Novel De Novo Mutations in KIF1A as a Cause of Hereditary Spastic Paraplegia With Progressive Central Nervous System Involvement. J Child Neurol 31:1114-9
Kahle, Kristopher T; Flores, Bianca; Bharucha-Goebel, Diana et al. (2016) Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter. Sci Signal 9:ra77
Harris, Elizabeth; Bladen, Catherine L; Mayhew, Anna et al. (2016) The Clinical Outcome Study for dysferlinopathy: An international multicenter study. Neurol Genet 2:e89
Elmer, David J; Laird, Richard H; Barberio, Matthew D et al. (2016) Inflammatory, lipid, and body composition responses to interval training or moderate aerobic training. Eur J Appl Physiol 116:601-9

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