The motivation for creation of this training program is the emergence and maturation of the field of regenerative medicine, especially as it relates to musculoskeletal disease. Investigational focus will be on the reconstitution of injured or missing musculoskeletal tissues with cells and small molecules embedded in a bioscaffold or matrix that possesses a nanostructure similar to that of the native tissue. We will focus training efforts on both the pre- and post-doctoral level trainees, the latter involving both Ph.D.s and M.D.s, intent on a career in interdisciplinary academic medicine in the general area of regenerative-restorative medicine. The first primary goal will be to provide trainees with combinatorial skill sets in 1) stem cell and developmental biology, 2) molecular genetics, 3) tissue engineering and materials science, 4) state-of the-art technologies in high-throughput, large scale computational science and 5) clinical-translational medicine that can be layered on top of their preceding undergraduate and graduate training in one of these areas. The second primary goal will be to educate trainees in an integrated approach to regenerative medicine with hands-on project-oriented teaching in how to i] build, ii] operate in and iii] modify a multidisciplinary team of colleagues. We will create and maintain an Interdisciplinary Institute of Musculoskeletal Regenerative Medicine (IIMSRM) composed of a tripartite team of 1) a training faculty, 2) a clinical faculty mentor and 3) a trainee. This team approach will ensure that the trainees will receive a comprehensive bench-to-bedside experience in what is required to actualize a bioengineered therapeutic in "real world" terms. This translational research structure will be supported by a robust collection of didactic curricula and seminar series, designed to introduce and refine the skills needed by both pre- and post-doctoral trainees to understand, design, compose, undertake and earn extramural financial support for a research project in regenerative medicine. The IIMSRM research and didactic training program is designed to provide individual trainees two years of support in preparation for their transition into more specialized training and alternative sources of support.

Public Health Relevance

to Public Health The relevance of the educational and research initiatives in this training program to the health of Americans encompasses the need to train the next generation of biomedical scientists in i) the application of cutting edge conceptual and technical strategies to musculoskeletal regenerative medicine and ii) the multidisciplinary, team approach required use those strategies from the laboratory to the bedside.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR059033-04
Application #
8727970
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Wang, Fei
Project Start
2011-08-11
Project End
2016-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
4
Fiscal Year
2014
Total Cost
$219,747
Indirect Cost
$17,515
Name
University of California Los Angeles
Department
Orthopedics
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Gibbs, Elizabeth M; Davidson, Ann E; Telfer, William R et al. (2014) The myopathy-causing mutation DNM2-S619L leads to defective tubulation in vitro and in developing zebrafish. Dis Model Mech 7:157-61
Alexander, Matthew S; Casar, Juan Carlos; Motohashi, Norio et al. (2014) MicroRNA-486-dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy-associated symptoms. J Clin Invest 124:2651-67
Valente, Enza Maria; Rosti, Rasim O; Gibbs, Elizabeth et al. (2014) Primary cilia in neurodevelopmental disorders. Nat Rev Neurol 10:27-36
Dhamdhere, Girija R; Fang, Mark Y; Jiang, Jie et al. (2014) Drugging a stem cell compartment using Wnt3a protein as a therapeutic. PLoS One 9:e83650
Orozco, Luz D; Rubbi, Liudmilla; Martin, Lisa J et al. (2014) Intergenerational genomic DNA methylation patterns in mouse hybrid strains. Genome Biol 15:R68
Weinstein, Michael M; Tompson, Stuart W; Chen, Yuqing et al. (2014) Mice expressing mutant Trpv4 recapitulate the human TRPV4 disorders. J Bone Miner Res 29:1815-22
Valenzuela, Nicole M; McNamara, Jeffrey T; Reed, Elaine F (2014) Antibody-mediated graft injury: complement-dependent and complement-independent mechanisms. Curr Opin Organ Transplant 19:33-40
Adams, John S; Rafison, Brandon; Witzel, Sten et al. (2014) Regulation of the extrarenal CYP27B1-hydroxylase. J Steroid Biochem Mol Biol 144 Pt A:22-7
Marshall, Jamie L; Kwok, Yukwah; McMorran, Brian J et al. (2013) The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy. FEBS J 280:4210-29