The basic purpose of the proposed program for Multidisciplinary Engineering Training in Musculoskeletal Research is to provide predoctoral trainees with a superb foundation in the biomedical engineering sciences and technologies that are a critical component of musculoskeletal research, while also teaching them the language of communication and collaboration with clinician and biomedical scientists in this broad field. Musculoskeletal research is a rich multidisciplinary field where some of the most exciting advances occur at the interface between the clinical, biological and engineering sciences. However, within each of these disciplines, a very broad range of sub-specializations exists. When a team of musculoskeletal researchers comes together, an optimal synergistic interaction is most likely to occur if each member brings the best and broadest level of expertise from his/her discipline to the table, while still being conversant in the areas of other team members. Thus, the training program proposed in this application is intended to provide trainees with a broad set of biomedical engineering foundations in biomechanics, cell and tissue engineering, and biomedical imaging, to enable excellence and leadership on interdisciplinary teams of musculoskeletal researchers, employing state-of-the-art engineering science, technology, and theoretical, computational and experimental techniques, in the study of the various soft and hard tissues of the musculoskeletal system. The program will capitalize on the large number of active musculoskeletal researchers at Columbia, their broad range of expertise, and extensive available resources. The program will recruit 3 new trainees per year on average, for a total of 15 trainees over the 5 year period of the project. Each trainee will be supported on this grant for two years, then transition to existing sponsored projects under the direction of one or more mentors.

Public Health Relevance

Engineering sciences and technologies represent a pillar of musculoskeletal research. Engineering breakthroughs can have a major impact on our understanding of disease progression and the development of clinical treatment modalities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR059038-03
Application #
8520182
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Wang, Fei
Project Start
2011-09-01
Project End
2016-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
3
Fiscal Year
2013
Total Cost
$250,154
Indirect Cost
$12,831
Name
Columbia University (N.Y.)
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
049179401
City
New York
State
NY
Country
United States
Zip Code
10027
Moore, Emily R; Zhu, Ya Xing; Ryu, Han Seul et al. (2018) Periosteal progenitors contribute to load-induced bone formation in adult mice and require primary cilia to sense mechanical stimulation. Stem Cell Res Ther 9:190
Moore, Emily R; Yang, Yuchen; Jacobs, Christopher R (2018) Primary cilia are necessary for Prx1-expressing cells to contribute to postnatal skeletogenesis. J Cell Sci 131:
Estell, Eben G; Murphy, Lance A; Silverstein, Amy M et al. (2017) Fibroblast-like synoviocyte mechanosensitivity to fluid shear is modulated by interleukin-1?. J Biomech 60:91-99
Boushell, Margaret K; Khanarian, Nora T; LeGeros, Raquel Z et al. (2017) Effect of ceramic calcium-phosphorus ratio on chondrocyte-mediated biosynthesis and mineralization. J Biomed Mater Res A 105:2694-2702
Qu, Dovina; Subramony, Siddarth D; Boskey, Adele L et al. (2017) Compositional mapping of the mature anterior cruciate ligament-to-bone insertion. J Orthop Res 35:2513-2523
Silverstein, Amy M; Stoker, Aaron M; Ateshian, Gerard A et al. (2017) Transient expression of the diseased phenotype of osteoarthritic chondrocytes in engineered cartilage. J Orthop Res 35:829-836
Nims, Robert J; Cigan, Alexander D; Durney, Krista M et al. (2017) * Constrained Cage Culture Improves Engineered Cartilage Functional Properties by Enhancing Collagen Network Stability. Tissue Eng Part A 23:847-858
Kim, Hyun Keol; Montejo, Ludguier D; Jia, Jingfei et al. (2017) Frequency-domain optical tomographic image reconstruction algorithm with the simplified spherical harmonics (SP3) light propagation model. Int J Therm Sci 116:265-277
Fong, Christopher J; Garzon, Maria C; Hoi, Jennifer W et al. (2017) Assessment of Infantile Hemangiomas Using a Handheld Wireless Diffuse Optical Spectroscopic Device. Pediatr Dermatol 34:386-391
Silverstein, A M; Stefani, R M; Sobczak, E et al. (2017) Toward understanding the role of cartilage particulates in synovial inflammation. Osteoarthritis Cartilage 25:1353-1361

Showing the most recent 10 out of 32 publications