The purpose of this Predoctoral Training Program is to facilitate the advancement of outstanding young investigators in Translational Musculoskeletal Research. This resubmission application seeks funding for four predoctoral slots per year to conduct research at the intersection of clinical medicine and surgery and basic science and engineering. The trainees will obtain a Ph.D. degree in Bioengineering or Materials Science and Engineering, typically five years in duration, with two years to be supported by this training grant. Mentorship for the program comes from a core of 21 well-funded and active faculty members in Departments or Divisions at the University of California, San Diego, while the university itself and local hospitals and research institutions offer state of the art research laboratories and resources. The program's formal course curriculum provides an interdisciplinary, innovative and rigorous educational experience. Trainees conduct doctoral research under the guidance of two mentors, one providing a basic science perspective, the other a clinical one. This mentorship structure will stimulate an interdisciplinary training environment conducive to fruitful research and discovery in musculoskeletal translation. Additionally, key aspects of the training program include: a clinical rotation with a clinical mentr in order to obtain a first- hand perspective of musculoskeletal disorders, participation in prominent conferences, career mentorship, training in grantsmanship, and weekly seminars from prominent speakers in fields including bioengineering, orthopaedic surgery and rheumatology. Trainees will thereby develop interdisciplinary research skills, between the bench and bedside, allowing them to springboard to careers that will improve the treatment, diagnosis, and prevention of musculoskeletal diseases and conditions.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZAR1-CHW (M2))
Program Officer
Wang, Fei
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University of California San Diego
Engineering (All Types)
Schools of Arts and Sciences
La Jolla
United States
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Martins, Vitor F; Tahvilian, Shahriar; Kang, Ji H et al. (2018) Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55? Subunit of Phosphoinositide 3-Kinase. Front Physiol 9:789
Svensson, Kristoffer; Dent, Jess R; Tahvilian, Shahriar et al. (2018) Defining the contribution of skeletal muscle pyruvate dehydrogenase alpha 1 (Pdha1) to exercise performance and insulin action. Am J Physiol Endocrinol Metab :
Meng, Zhipeng; Qiu, Yunjiang; Lin, Kimberly C et al. (2018) RAP2 mediates mechanoresponses of the Hippo pathway. Nature 560:655-660
Gibbons, Michael C; Singh, Anshuman; Engler, Adam J et al. (2018) The role of mechanobiology in progression of rotator cuff muscle atrophy and degeneration. J Orthop Res 36:546-556
Svensson, K; LaBarge, S A; Martins, V F et al. (2017) Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis. Acta Physiol (Oxf) 221:193-203
Kumar, Aditya; Placone, Jesse K; Engler, Adam J (2017) Understanding the extracellular forces that determine cell fate and maintenance. Development 144:4261-4270
Takase, Fumiaki; Inui, Atsuyuki; Mifune, Yutaka et al. (2017) Effect of platelet-rich plasma on degeneration change of rotator cuff muscles: In vitro and in vivo evaluations. J Orthop Res 35:1806-1815
Dent, Jessica R; Martins, Vitor F; Svensson, Kristoffer et al. (2017) Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation. Mol Metab 6:1574-1584
Thomas, Kelsey A; Gibbons, Michael C; Lane, John G et al. (2017) Rotator cuff tear state modulates self-renewal and differentiation capacity of human skeletal muscle progenitor cells. J Orthop Res 35:1816-1823
Shahidi, Bahar; Hubbard, James C; Gibbons, Michael C et al. (2017) Lumbar multifidus muscle degenerates in individuals with chronic degenerative lumbar spine pathology. J Orthop Res 35:2700-2706

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