This application seeks to establish a Dermatology Investigator Training Program at the University of California, San Diego (UCSD) to train promising pre-doctoral and post- doctoral students and prepare them for a productive academic career in investigative dermatology. Skin research at UCSD has been extraordinarily productive in recent years and we have organized outstanding faculty with a proven track record in mentorship and conducting ground-breaking cutting edge research in skin biology. The goals of this program are to take advantage of our unparalleled institutional scientific resources, a well-funded base of dermatology research faculty and outstandingly equipped centralized modern laboratory space of over 8000 sq. ft. Our program proposes to use these to train much-needed future independent research investigators in skin biology. Our core dermatology faculty will be assisted in training by a network of actively collaborating basic science investigators that have a proven publication record in dermatology and a long history of successful mentorship. Together, these scientific faculty will immediately provide us with a critical mass of pre-doctoral and post-doctoral students to drive a vibrant training program. The UCSD Dermatology Investigator Training Program will be further enriched by a formalized co-mentorship program with outstanding clinical investigators, thus propelling PhD student research into opportunities for translational application of basic research projects. Emphasis will be placed in our leadership in conducting research in skin inflammation, infection and epidermal genetics and development. Promising trainees will be identified by an active recruitment program for physician-scientists, women and minorities, an active seminar and didactic series, and ongoing enrichment programs within the San Diego biomedical community. These strengths will ensure our ultimate goal to inspire and provide outstanding training for the next generation of academic researchers in investigative dermatology.

Public Health Relevance

The Dermatology Investigator Training Program at UCSD will leverage the outstanding scientific environment of one of the top research universities in the nation, and combine this with a productive translational program in dermatology. Our goal is to address a shortage of qualified investigators involved in skin disease research and thus decrease morbidity and mortality among a large population suffering from dermatologic disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR062496-02
Application #
8451411
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Cibotti, Ricardo
Project Start
2012-05-01
Project End
2017-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
2
Fiscal Year
2013
Total Cost
$197,548
Indirect Cost
$13,424
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Williams, Michael R; Nakatsuji, Teruaki; Sanford, James A et al. (2016) Staphylococcus aureus Induces Increased Serine Protease Activity in Keratinocytes. J Invest Dermatol :
Adase, Christopher A; Borkowski, Andrew W; Zhang, Ling-Juan et al. (2016) Non-coding Double-stranded RNA and Antimicrobial Peptide LL-37 Induce Growth Factor Expression from Keratinocytes and Endothelial Cells. J Biol Chem 291:11635-46
Zhang, Ling-Juan; Sen, George L; Ward, Nicole L et al. (2016) Antimicrobial Peptide LL37 and MAVS Signaling Drive Interferon-β Production by Epidermal Keratinocytes during Skin Injury. Immunity 45:119-30
Sato, Emi; Muto, Jun; Zhang, Ling-Juan et al. (2016) The Parathyroid Hormone Second Receptor PTH2R and its Ligand Tuberoinfundibular Peptide of 39 Residues TIP39 Regulate Intracellular Calcium and Influence Keratinocyte Differentiation. J Invest Dermatol 136:1449-59
Bouslimani, Amina; Porto, Carla; Rath, Christopher M et al. (2015) Molecular cartography of the human skin surface in 3D. Proc Natl Acad Sci U S A 112:E2120-9
Borkowski, Andrew W; Kuo, I-Hsin; Bernard, Jamie J et al. (2015) Toll-like receptor 3 activation is required for normal skin barrier repair following UV damage. J Invest Dermatol 135:569-78
Mistry, Devendra S; Chen, Yifang; Wang, Ying et al. (2015) Transcriptional profiling of SNAI2 regulated genes in primary human keratinocytes. Genom Data 4:43-46
MacLeod, Daniel T; Nakatsuji, Teruaki; Wang, Zhenping et al. (2015) Vaccinia virus binds to the scavenger receptor MARCO on the surface of keratinocytes. J Invest Dermatol 135:142-50
Borkowski, Andrew W; Gallo, Richard L (2014) UVB radiation illuminates the role of TLR3 in the epidermis. J Invest Dermatol 134:2315-20
Lin, Ann E; Autran, Chloe A; Espanola, Sophia D et al. (2014) Human milk oligosaccharides protect bladder epithelial cells against uropathogenic Escherichia coli invasion and cytotoxicity. J Infect Dis 209:389-98

Showing the most recent 10 out of 23 publications