Support is requested for years 35-40 of a long-standing training program in cancer research for postdoctoral fellows at the Fox Chase Cancer Center. The Training Faculty consists of 47 Mentors (11 Assistant Professor, 15 Associate Professor, 21 Full Professor) with diverse interests in cell growth control, signal transduction, oncogenes and tumor suppressor genes, angiogenesis, epigenetics, cancer prevention, programmed cell death, bio-behavioral cancer research, immunology, mouse models of cancer, and developmental therapeutics. The well-funded and highly collaborative Training Faculty come from five different research programs: Immune Cell Development and Host Defense, Cancer Biology, Developmental Therapeutics, Women's Cancer, and Cancer Prevention and Control. The postdoctoral pool is extremely strong;there are 4 applicants per open slot, and the majority of applicants received graduate training at outstanding Institutions and are published in high- impact journals. The program offers diverse training in areas relevant to cancer research, with a combination of didactic and laboratory-based training, including seminar series, journal clubs, grant- writing workshops, and educational series. Input from the postdoctoral pool is extensive and highly valued;trainee satisfaction is best exemplified by our placement, every year for the past seven years, in the Top 20 "Best Places in the United States for Postdoctoral Training", as determined by anonymous survey and published in The Scientist magazine. Funding for 10 trainees per year is requested;this is less than one quarter the citizenship-eligible trainees in the labs of the training faculty. Trainee slots are highly competitive and have been continuously filled for the last 2 funding cycles. Finally, 82% of trainees who have completed training and left this program report that they are still doing research directly relevant to cancer, indicating that we are fulfilling our goal of training the future of cancer research. Finally, this training program serves as the nucleus of our postdoctoral program. Its continued success is vital to the mission of Fox Chase Cancer Center.

Public Health Relevance

Cancer continues to be a major health issue in the United States. With a highly collaborative faculty, a diverse and rigorous training program, an outstanding pool of postdoctoral fellows and cutting-edge research questions, this training program seeks to train the future scientists in cancer research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009035-37
Application #
8333976
Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
Project Start
1975-07-01
Project End
2016-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
37
Fiscal Year
2012
Total Cost
$446,748
Indirect Cost
$41,133
Name
Research Institute of Fox Chase Cancer Center
Department
Type
DUNS #
064367329
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
Fink, Lauren S; Beatty, Alexander; Devarajan, Karthik et al. (2015) Pharmacological profiling of kinase dependency in cell lines across triple-negative breast cancer subtypes. Mol Cancer Ther 14:298-306
Yuelling, Larra W; Du, Fang; Li, Peng et al. (2014) Isolation of distinct cell populations from the developing cerebellum by microdissection. J Vis Exp :52034
Little, J L; Serzhanova, V; Izumchenko, E et al. (2014) A requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 mice. Oncogene 33:411-20
Purdy, Amanda K; Alvarez Arias, Diana A; Oshinsky, Jennifer et al. (2014) The ap-2 clathrin adaptor mediates endocytosis of an inhibitory killer cell Ig-like receptor in human NK cells. J Immunol 193:4675-83
Domanitskaya, N; Wangari-Talbot, J; Jacobs, J et al. (2014) Abcc10 status affects mammary tumour growth, metastasis, and docetaxel treatment response. Br J Cancer 111:696-707
Remakus, Sanda; Rubio, Daniel; Lev, Avital et al. (2013) Memory CD8? T cells can outsource IFN-? production but not cytolytic killing for antiviral protection. Cell Host Microbe 13:546-57
Anastassiadis, Theonie; Duong-Ly, Krisna C; Deacon, Sean W et al. (2013) A highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-regulated kinase (ERK) inhibitor. J Biol Chem 288:28068-77
Duong-Ly, Krisna C; Peterson, Jeffrey R (2013) The human kinome and kinase inhibition. Curr Protoc Pharmacol Chapter 2:Unit2.9
Heckman, Carolyn J; Darlow, Susan; Manne, Sharon L et al. (2013) Correspondence and correlates of couples' skin cancer screening. JAMA Dermatol 149:825-30
Slusky, Joanna S G; Dunbrack Jr, Roland L (2013) Charge asymmetry in the proteins of the outer membrane. Bioinformatics 29:2122-8

Showing the most recent 10 out of 55 publications