The Cancer Biology Training Grant (CBTG) at the University of Minnesota Masonic Cancer Center combines rigorous training in laboratory-based cancer research with interdisciplinary and translational perspectives that prepares CBTG trainees for independent research careers in cancer biology. Now in its 35th year of NCI support, the CBTG supports 4 predoctoral and 4 postdoctoral trainees. All trainees are selected on a competitive basis using clearly-defined criteria. The 39 preceptors provide research training in four areas of research strength at the Masonic Cancer Center: tumor biology and progression, cancer immunology, cancer genetics, and cancer therapy. The training program consists of intensive one-on-one research mentoring, didactic training in cancer biology, regular CBTG-specific meetings where trainees obtain feedback, develop critical presentation skills and establish new research collaborations, networking opportunities with prominent external cancer biology scientists, and formal career development activities. Enhanced monitoring and evaluation of trainee progress, and participation of the CBTG Director and Steering Committee members in key leadership positions associated with graduate education and trainee recruitment at the University of Minnesota, have enhanced the CBTG applicant pool and improved the career outcomes of CBTG trainees. These efforts have also enhanced our success at recruiting individuals from under-represented groups. New initiatives during the next funding period include the establishment of a new required graduate-level course in translational cancer research that will expose trainees to clinical issues in cancer biology research and to the realities of cancer patient treatment and care, establishment of an External Advisory Board and formal exit interviews with trainees to enhance CBTG program evaluation and development, and re-organization of CBTG leadership responsibilities to more effectively administer the various components of the CBTG program. The CBTG is central to the Masonic Cancer Center's mission of educating and training the next generation of scientific leaders pursuing research into the etiology and treatment of cancer.

Public Health Relevance

This goal of this program at the University of Minnesota Masonic Cancer Center is to train a diverse group of highly qualified individuals to become future scientific leaders working in basic laboratory research to address fundamental problems in cancer biology.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009138-38
Application #
8309341
Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
Project Start
1980-07-01
Project End
2015-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
38
Fiscal Year
2012
Total Cost
$359,786
Indirect Cost
$28,974
Name
University of Minnesota Twin Cities
Department
Pathology
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Dressing, Gwen E; Knutson, Todd P; Schiewer, Matthew J et al. (2014) Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells. Mol Endocrinol 28:442-57
Sawicka, Maria; Stritesky, Gretta L; Reynolds, Joseph et al. (2014) From pre-DP, post-DP, SP4, and SP8 Thymocyte Cell Counts to a Dynamical Model of Cortical and Medullary Selection. Front Immunol 5:19
Bohrer, Laura R; Chuntova, Pavlina; Bade, Lindsey K et al. (2014) Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation. Cancer Res 74:374-86
Fogarty, Keir H; Berk, Serkan; Grigsby, Iwen F et al. (2014) Interrelationship between cytoplasmic retroviral Gag concentration and Gag-membrane association. J Mol Biol 426:1611-24
Olson, Janelle A; McDonald-Hyman, Cameron; Jameson, Stephen C et al. (2013) Effector-like CD8? T cells in the memory population mediate potent protective immunity. Immunity 38:1250-60
Burns, Michael B; Lackey, Lela; Carpenter, Michael A et al. (2013) APOBEC3B is an enzymatic source of mutation in breast cancer. Nature 494:366-70
Balfour Jr, Henry H; Odumade, Oludare A; Schmeling, David O et al. (2013) Behavioral, virologic, and immunologic factors associated with acquisition and severity of primary Epstein-Barr virus infection in university students. J Infect Dis 207:80-8
Ohlfest, John R; Andersen, Brian M; Litterman, Adam J et al. (2013) Vaccine injection site matters: qualitative and quantitative defects in CD8 T cells primed as a function of proximity to the tumor in a murine glioma model. J Immunol 190:613-20
Andersen, Brian M; Pluhar, G Elizabeth; Seiler, Charles E et al. (2013) Vaccination for invasive canine meningioma induces in situ production of antibodies capable of antibody-dependent cell-mediated cytotoxicity. Cancer Res 73:2987-97
Stritesky, Gretta L; Xing, Yan; Erickson, Jami R et al. (2013) Murine thymic selection quantified using a unique method to capture deleted T cells. Proc Natl Acad Sci U S A 110:4679-84

Showing the most recent 10 out of 141 publications