The Cancer Biology Training Grant (CBTG) at the University of Minnesota Masonic Cancer Center combines rigorous training in laboratory-based cancer research with interdisciplinary and translational perspectives that prepares CBTG trainees for independent research careers in cancer biology. Now in its 35th year of NCI support, the CBTG supports 4 predoctoral and 4 postdoctoral trainees. All trainees are selected on a competitive basis using clearly-defined criteria. The 39 preceptors provide research training in four areas of research strength at the Masonic Cancer Center: tumor biology and progression, cancer immunology, cancer genetics, and cancer therapy. The training program consists of intensive one-on-one research mentoring, didactic training in cancer biology, regular CBTG-specific meetings where trainees obtain feedback, develop critical presentation skills and establish new research collaborations, networking opportunities with prominent external cancer biology scientists, and formal career development activities. Enhanced monitoring and evaluation of trainee progress, and participation of the CBTG Director and Steering Committee members in key leadership positions associated with graduate education and trainee recruitment at the University of Minnesota, have enhanced the CBTG applicant pool and improved the career outcomes of CBTG trainees. These efforts have also enhanced our success at recruiting individuals from under-represented groups. New initiatives during the next funding period include the establishment of a new required graduate-level course in translational cancer research that will expose trainees to clinical issues in cancer biology research and to the realities of cancer patient treatment and care, establishment of an External Advisory Board and formal exit interviews with trainees to enhance CBTG program evaluation and development, and re-organization of CBTG leadership responsibilities to more effectively administer the various components of the CBTG program. The CBTG is central to the Masonic Cancer Center's mission of educating and training the next generation of scientific leaders pursuing research into the etiology and treatment of cancer.

Public Health Relevance

This goal of this program at the University of Minnesota Masonic Cancer Center is to train a diverse group of highly qualified individuals to become future scientific leaders working in basic laboratory research to address fundamental problems in cancer biology.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Institutional National Research Service Award (T32)
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Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
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University of Minnesota Twin Cities
Schools of Medicine
United States
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Law, Emily K; Sieuwerts, Anieta M; LaPara, Kelly et al. (2016) The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer. Sci Adv 2:e1601737
LaRocca, Christopher J; Han, Joohee; Salzwedel, Amanda O et al. (2016) Oncolytic adenoviruses targeted to Human Papilloma Virus-positive head and neck squamous cell carcinomas. Oral Oncol 56:25-31
Flynn, Ryan; Paz, Katelyn; Du, Jing et al. (2016) Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism. Blood 127:2144-54
Regan Anderson, Tarah M; Ma, Shi Hong; Raj, Ganesh V et al. (2016) Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer. Cancer Res 76:1653-63
Leonard, Brandon; Starrett, Gabriel J; Maurer, Matthew J et al. (2016) APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma. Clin Cancer Res 22:4746-55
Van Etten, Jamie L; Dehm, Scott M (2016) Clonal origin and spread of metastatic prostate cancer. Endocr Relat Cancer 23:R207-17
Diep, Caroline H; Ahrendt, Hannah; Lange, Carol A (2016) Progesterone induces progesterone receptor gene (PGR) expression via rapid activation of protein kinase pathways required for cooperative estrogen receptor alpha (ER) and progesterone receptor (PR) genomic action at ER/PR target genes. Steroids 114:48-58
Diep, Caroline H; Knutson, Todd P; Lange, Carol A (2016) Active FOXO1 Is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming. Mol Cancer Res 14:141-62
Renkema, Kristin R; Lee, June-Yong; Lee, You Jeong et al. (2016) IL-4 sensitivity shapes the peripheral CD8+ T cell pool and response to infection. J Exp Med 213:1319-29
Fulton, Ross B; Hamilton, Sara E; Xing, Yan et al. (2015) The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigens. Nat Immunol 16:107-17

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