Originally awarded in 1976, this application requests a five-year renewal of the T32 Training Program in Immunology at the Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center (MSK). The objective of this Training Program is to provide junior postdoctoral fellows a solid foundation in the field of Immunology and to direct their interests towards important aspects of the immune system and its response to infectious agents, self antigens, and cancer. Three postdoctoral positions are requested for this competitive renewal. The duration of training for each trainee will be up to three years. The Training Program provides trainees with the intensive training, resources and experience necessary for them to develop successful careers in academia, government, and industry as independent researchers, mentors, and leaders. Areas of research training include tumor immunity and immune-oncology, bone marrow transplantation, lymphocyte and myeloid cell differentiation and biology, cell signaling, microbiota-host interactions, innate immunity, infectious immunity with a focus on cancer patients related infections. The objective of the Training Program is achieved by providing a structured environment with intensive involvement in immunology research, further strengthened by attendance at weekly seminars and research-in-progress meetings, monthly research colloquia and translational research seminars and an annual retreat. Trainees are also expected to participate in advanced courses covering contemporary topics of immunology and workshops on bioinformatics and grant writing skills. The major part of the training comes from the research experience under the tutelage of preceptors who are engaged in cutting-edge immunology research, with bearing on cancer and tumor immunity and related aspects of immune cell development and function at molecular, cellular and organismal levels. Trainees will be also taking advantage of the extensive interdisciplinary collaborations between members of the Immunology Training Program and respected outside scientists, both locally and nationally.

Public Health Relevance

Among the major health problems afflicting the US populace today cancer and related diseases have become particularly prevalent. The Immunology Taining Program we propose will train a new cohort of postdoctoral scientists in immunology, with an emphasis on learning how the immune system interacts with tumor cells and how to mobilize the immune system to attack tumors. There have been recent remarkable successes in clinical trials in modulating the immune system to effectively treat cancer in humans, and our goal is to train new scientists to continue and expand this approach to cancer therapy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
2T32CA009149-41A1
Application #
9416563
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Lim, Susan E
Project Start
1976-07-01
Project End
2022-12-31
Budget Start
2018-01-17
Budget End
2018-12-31
Support Year
41
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Yewdell, William T; Chaudhuri, Jayanta (2017) Molecular biology: RNA editing packs a one-two punch. Nature 542:420-421
Drané, Pascal; Brault, Marie-Eve; Cui, Gaofeng et al. (2017) TIRR regulates 53BP1 by masking its histone methyl-lysine binding function. Nature 543:211-216
Vaidyanathan, Bharat; Chaudhry, Ashutosh; Yewdell, William T et al. (2017) The aryl hydrocarbon receptor controls cell-fate decisions in B cells. J Exp Med 214:197-208
Oh, Soyoung A; Liu, Ming; Nixon, Briana G et al. (2017) Foxp3-independent mechanism by which TGF-? controls peripheral T cell tolerance. Proc Natl Acad Sci U S A 114:E7536-E7544
Casellas, Rafael; Basu, Uttiya; Yewdell, William T et al. (2016) Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity. Nat Rev Immunol 16:164-76
Stamatiades, Efstathios G; Tremblay, Marie-Eve; Bohm, Mathieu et al. (2016) Immune Monitoring of Trans-endothelial Transport by Kidney-Resident Macrophages. Cell 166:991-1003
Abt, Michael C; McKenney, Peter T; Pamer, Eric G (2016) Clostridium difficile colitis: pathogenesis and host defence. Nat Rev Microbiol 14:609-20
Lupoli, Tania J; Fay, Allison; Adura, Carolina et al. (2016) Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK. Proc Natl Acad Sci U S A 113:E7947-E7956
Buffie, Charlie G; Bucci, Vanni; Stein, Richard R et al. (2015) Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature 517:205-8
Harris, Kendra K; Fay, Allison; Yan, Han-Guang et al. (2014) Novel imidazoline antimicrobial scaffold that inhibits DNA replication with activity against mycobacteria and drug resistant Gram-positive cocci. ACS Chem Biol 9:2572-83

Showing the most recent 10 out of 40 publications