This proposal seeks support for 14 postdoctoral fellows for a two year training curriculum within an established and highly successful program (Interdisciplinary Training in Cancer Model Systems ? ITCMS) that instills interdisciplinary approaches to address basic and translational approaches in cancer research. The 51 ITCMS mentors are chosen from 325 core faculty of the UNC Lineberger Cancer Center (LCCC). Faculty are housed within academic departments in the UNC School of Medicine, the College of Arts and Sciences, and the School of Pharmacy and are members of the five basic/translational LCCC programs: Cancer Cell Biology, Immunology, Molecular Therapeutics, Virology and Cancer Genetics as well as the Clinical Research Program. This pool of mentors allows fellows to engage in interdisciplinary studies from basic science to bioinformatics to translational studies, utilizing state of the art cancer models. The ITCMS program is administered by its Director and Associate Director, with advice from the Training Committee, and both External and Internal Advisory Boards. Preceptor and trainee input on the training program is accomplished through an annual, anonymous survey. Training is enhanced by access to the Center's core facilities, supported by the Center's NCI Core Grant (rated ?exceptional?). LCCC commitment to ITCMS is significant and includes support for an additional two postdoctoral slots. Fellows jointly apply to the ITCMS and one or more mentor laboratories and undergo a rigorous selection process. Upon appointment, each fellow develops a training plan approved by the mentor, the mentoring committee, and the Director. Each fellow participates in the following: (i) monthly in-house postdoctoral seminars given by the fellows, (ii) the annual Lineberger Postdoctoral-Faculty Research Day, organized by a Faculty Advisor and the Postdoctoral Fellows Committee, (iii) panel discussions on careers including advice for successful faculty applications and interviews, (iv) sessions on ethics in research (vi) a monthly research club, (vi) clinical exposure (physician shadowing and tumor board participation), (vii) interactions with patient advocates, and (viii) a grant writing and grant review program. Based on the individualized training plan, fellows participate in relevant training workshops (such as proteomics, microscopy, mouse histopathology, genomics, etc.). Progress is monitored annually by the Director and Associate Director, along with the Training Oversight Committee, before renewal for Year 2 support. Since its inception, the program has been committed to recruiting and successful training of minorities. The success of previous fellows, with the great majority continuing in a cancer or science-related field, underscores the importance placed on postdoctoral training in the ITCMS.

Public Health Relevance

The ITCMS postdoctoral training program at the UNC Lineberger Cancer Center is designed to provide exceptional interdisciplinary training with outstanding preceptors in areas of basic and translational cancer research with an emphasis on cancer model systems. This successful program has completed its 40th year and is under the able directorship of Dr. Joseph Pagano, who originally founded the cancer center and the training program. The success of the program has moved in step with the success of the University of North Carolina and its nationally recognized cancer research efforts. We request support for 14 postdoctoral trainees over the next 5 years.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009156-44
Application #
9749031
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Damico, Mark W
Project Start
1980-07-01
Project End
2021-07-31
Budget Start
2019-08-01
Budget End
2020-07-31
Support Year
44
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Chiang, Yun-Chen; Park, In-Young; Terzo, Esteban A et al. (2018) SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma. Cancer Res 78:3135-3146
Turcot, Valérie (see original citation for additional authors) (2018) Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet 50:766-767
Heppert, Jennifer K; Pani, Ariel M; Roberts, Allyson M et al. (2018) A CRISPR Tagging-Based Screen Reveals Localized Players in Wnt-Directed Asymmetric Cell Division. Genetics 208:1147-1164
Rojas, Juan D; Lin, Fanglue; Chiang, Yun-Chen et al. (2018) Ultrasound Molecular Imaging of VEGFR-2 in Clear-Cell Renal Cell Carcinoma Tracks Disease Response to Antiangiogenic and Notch-Inhibition Therapy. Theranostics 8:141-155
Bonacci, Thomas; Suzuki, Aussie; Grant, Gavin D et al. (2018) Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates. EMBO J 37:
Farquhar, Douglas R; Taylor, James M; Mazul, Angela L et al. (2018) HPV-Positive Oropharyngeal Squamous Cell Carcinoma among Patients Taking Adalimumab for Autoimmune Disorders. Otolaryngol Head Neck Surg 159:593-594
Stepp, Wesley H; Farquhar, Douglas; Sheth, Siddharth et al. (2018) RNA Oncoimmune Phenotyping of HPV-Positive p16-Positive Oropharyngeal Squamous Cell Carcinomas by Nodal Status. JAMA Otolaryngol Head Neck Surg 144:967-975
Mustoe, Anthony M; Busan, Steven; Rice, Greggory M et al. (2018) Pervasive Regulatory Functions of mRNA Structure Revealed by High-Resolution SHAPE Probing. Cell 173:181-195.e18
Mazul, Angela L; Shivappa, Nitin; Hébert, James R et al. (2018) Proinflammatory diet is associated with increased risk of squamous cell head and neck cancer. Int J Cancer :
Bohn, Jennifer A; Van Etten, Jamie L; Schagat, Trista L et al. (2018) Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins. Nucleic Acids Res 46:362-386

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