Funding is requested to continue the training of individuals for careers in cancer research. Predoctoral trainees are Ph.D. or M.D./Ph.D. candidates who conduct cancer related thesis research at the Wistar Institute in partial fulfillment of the Ph.D. requirements of the University of Pennsylvania. Postdoctoral training is designed to prepare individuals for independent research careers in cancer-related areas in basic research and clinical settings. The program is devoted to laboratory research training that is complemented by a biweekly Research in Progress Series, a weekly cancer- focused Wistar Institute Lecture Series, a biweekly Cancer Biology Journal Club, a yearly Cancer Biology Retreat, a Cancer Biology Lecture Course, a yearly seminar series in Grant Proposal Planning and Preparation and yearly training in The Responsible Conduct of Research. Trainees also actively participate in other relevant lectures series and national and international conferences. The proposed trainers head 21 independent laboratories from the three programs at the Wistar Institute;Gene Expression and Regulation, Molecular and Cellular Oncogenesis and Immunology. Trainers participate in all training program activities including the recruitment into the program of Underrepresented Minorities. The trainers in the program share a common interest in cancer research and together cover both basic and translational aspects. A unique feature of the program is that it is unusually interactive and collaborative resulting in many program projects and collaborative publications involving trainers and trainees both within and between the three institute programs. All participating trainers continually succeed in attracting excellent predoctoral and postdoctoral fellows including URM trainees to participate in the research program described. Each of the participating trainers successfully compete for mostly federal but also non-federal grant support in cancer research with over 62 % of the participating trainers supported by the NCI and the rest of the trainers supported by other cancer- related funding. Altogether, this training program offers training in """"""""cutting edge"""""""" basic cancer research that will prepare the participating trainee for a productive career in science that will advance our understanding of the malignant process.

Public Health Relevance

Funding is requested to continue the training of individuals for careers in cancer research. This training program offers training in cutting edge basic cancer research that will prepare the participating trainees for a productive career in science that will advance our understanding of the malignant process.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009171-38
Application #
8786817
Study Section
Subcommittee B - Comprehensiveness (NCI)
Program Officer
Lim, Susan E
Project Start
1976-07-01
Project End
2017-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
38
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Wistar Institute
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Patel, Sima; Fu, Shuyu; Mastio, Jerome et al. (2018) Unique pattern of neutrophil migration and function during tumor progression. Nat Immunol 19:1236-1247
Gnanapradeepan, Keerthana; Basu, Subhasree; Barnoud, Thibaut et al. (2018) The p53 Tumor Suppressor in the Control of Metabolism and Ferroptosis. Front Endocrinol (Lausanne) 9:124
Echevarría-Vargas, Ileabett M; Reyes-Uribe, Patricia I; Guterres, Adam N et al. (2018) Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma. EMBO Mol Med 10:
Basu, Subhasree; Gnanapradeepan, Keerthana; Barnoud, Thibaut et al. (2018) Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1?. Genes Dev 32:230-243
Perales-Puchalt, Alfredo; Perez-Sanz, Jairo; Payne, Kyle K et al. (2018) Frontline Science: Microbiota reconstitution restores intestinal integrity after cisplatin therapy. J Leukoc Biol 103:799-805
Reyes-Uribe, Patricia; Adrianzen-Ruesta, Maria Paz; Deng, Zhong et al. (2018) Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma. Oncogene 37:4058-4072
Fukumoto, Takeshi; Park, Pyoung Hwa; Wu, Shuai et al. (2018) Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer. Cell Rep 22:3393-3400
Kaur, Amanpreet; Ecker, Brett L; Douglass, Stephen M et al. (2018) Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility. Cancer Discov :
Nacarelli, Timothy; Liu, Pingyu; Zhang, Rugang (2017) Epigenetic Basis of Cellular Senescence and Its Implications in Aging. Genes (Basel) 8:
Barnoud, Thibaut; Schmidt, M Lee; Donninger, Howard et al. (2017) The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence. Cancer Lett 400:30-36

Showing the most recent 10 out of 228 publications